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Progress, applications, and challenges in high-throughput effect-directed analysis for toxicity driver identification : is it time for HT-EDA?

Alvarez-Mora, Iker (författare)
Department of Exposure Science, Helmholtz Centre for Environmental Research, UFZ, Leipzig, Germany; Research Centre for Experimental Marine Biology and Biotechnology (PIE), University of the Basque Country (UPV/EHU), Basque Country, Plentzia, Spain
Arturi, Katarzyna (författare)
Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dübendorf, Switzerland
Béen, Frederic (författare)
KWR Water Research Institute, Nieuwegein, Netherlands; Chemistry for Environment and Health, Amsterdam Institute for Life and Environment (A-LIFE), Vrije Universiteit Amsterdam, Amsterdam, Netherlands
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Buchinger, Sebastian (författare)
Department of Biochemistry and Ecotoxicology, Federal Institute of Hydrology (BfG), Koblenz, Germany
El Mais, Abd El Rahman (författare)
Ineris, Parc Technologique Alata, Verneuil-en-Halatte, France
Gallampois, Christine, 1974- (författare)
Umeå universitet,Kemiska institutionen
Hahn, Meike (författare)
Department of Biochemistry and Ecotoxicology, Federal Institute of Hydrology (BfG), Koblenz, Germany
Hollender, Juliane (författare)
Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dübendorf, Switzerland; Institute of Biogeochemistry and Pollutant Dynamics, ETH Zurich, Zürich, Switzerland
Houtman, Corine (författare)
Chemistry for Environment and Health, Amsterdam Institute for Life and Environment (A-LIFE), Vrije Universiteit Amsterdam, Amsterdam, Netherlands; The Water Laboratory, Haarlem, Netherlands
Johann, Sarah (författare)
Department of Evolutionary Ecology and Environmental Toxicology, Goethe University Frankfurt, Frankfurt Am Main, Germany
Krauss, Martin (författare)
Department of Exposure Science, Helmholtz Centre for Environmental Research, UFZ, Leipzig, Germany
Lamoree, Marja (författare)
Chemistry for Environment and Health, Amsterdam Institute for Life and Environment (A-LIFE), Vrije Universiteit Amsterdam, Amsterdam, Netherlands
Margalef, Maria (författare)
Chemistry for Environment and Health, Amsterdam Institute for Life and Environment (A-LIFE), Vrije Universiteit Amsterdam, Amsterdam, Netherlands
Massei, Riccardo (författare)
Department of Monitoring and Exploration Technologies, Research Data Management Team (RDM), Helmholtz Centre for Environmental Research, UFZ, Leipzig, Germany; Department of Ecotoxicology, Group of Integrative Toxicology (iTox), Helmholtz Centre for Environmental Research, UFZ, Leipzig, Germany
Brack, Werner (författare)
Department of Exposure Science, Helmholtz Centre for Environmental Research, UFZ, Leipzig, Germany; Department of Evolutionary Ecology and Environmental Toxicology, Goethe University Frankfurt, Frankfurt Am Main, Germany
Muz, Melis (författare)
Department of Exposure Science, Helmholtz Centre for Environmental Research, UFZ, Leipzig, Germany
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 (creator_code:org_t)
2024
2024
Engelska.
Ingår i: Analytical and Bioanalytical Chemistry. - : Springer Nature. - 1618-2642 .- 1618-2650.
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
Stäng  
  • The rapid increase in the production and global use of chemicals and their mixtures has raised concerns about their potential impact on human and environmental health. With advances in analytical techniques, in particular, high-resolution mass spectrometry (HRMS), thousands of compounds and transformation products with potential adverse effects can now be detected in environmental samples. However, identifying and prioritizing the toxicity drivers among these compounds remain a significant challenge. Effect-directed analysis (EDA) emerged as an important tool to address this challenge, combining biotesting, sample fractionation, and chemical analysis to unravel toxicity drivers in complex mixtures. Traditional EDA workflows are labor-intensive and time-consuming, hindering large-scale applications. The concept of high-throughput (HT) EDA has recently gained traction as a means of accelerating these workflows. Key features of HT-EDA include the combination of microfractionation and downscaled bioassays, automation of sample preparation and biotesting, and efficient data processing workflows supported by novel computational tools. In addition to microplate-based fractionation, high-performance thin-layer chromatography (HPTLC) offers an interesting alternative to HPLC in HT-EDA. This review provides an updated perspective on the state-of-the-art in HT-EDA, and novel methods/tools that can be incorporated into HT-EDA workflows. It also discusses recent studies on HT-EDA, HT bioassays, and computational prioritization tools, along with considerations regarding HPTLC. By identifying current gaps in HT-EDA and proposing new approaches to overcome them, this review aims to bring HT-EDA a step closer to monitoring applications.

Ämnesord

NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
NATURVETENSKAP  -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
NATURAL SCIENCES  -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)

Nyckelord

Bioanalytical methods
HT-EDA
Mass spectrometry
NTS

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