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Sökning: WFRF:(Bachmann Radu) > (2022) > Akkermansia mucinip...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006396naa a2200517 4500
001oai:DiVA.org:oru-101170
003SwePub
008220912s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1011702 URI
0247 a https://doi.org/10.3390/cells111726662 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bachmann, Raduu Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life Sciences and BIOtechnology (WELBIO), UCLouvain, Université Catholique de Louvain, Brussels, Belgium; Colorectal Surgery Unit, Cliniques Universitaires Saint-Luc, Brussels, Belgium4 aut
2451 0a Akkermansia muciniphila Reduces Peritonitis and Improves Intestinal Tissue Wound Healing after a Colonic Transmural Defect by a MyD88-Dependent Mechanism
264 c 2022-08-27
264 1b MDPI,c 2022
338 a print2 rdacarrier
500 a Funding agencies:Fonds de la Recherche Scientifique - FNRS FNRS T.0030.21 J.0027.22 WELBIO-CR-2022A-02 WELBIO-CR-2019C-02R 30770923 40007505  Netherlands Organization for Scientific Research (NWO) 024.002.002
520 a Anastomotic leakage is a major complication following colorectal surgery leading to peritonitis, complications, and mortality. Akkermansia muciniphila has shown beneficial effects on the gut barrier function. Whether A. muciniphila reduces peritonitis and mortality during colonic leakage is unknown. Whether A. muciniphila can directly modulate the expression of genes in the colonic mucosa in humans has never been studied. We investigated the effects of a pretreatment (14 days) with live A. muciniphila prior to surgical colonic perforation on peritonitis, mortality, and wound healing. We used mice with an inducible intestinal-epithelial-cell-specific deletion of MyD88 (IEC-MyD88 KO) to investigate the role of the innate immune system in this context. In a proof-of-concept pilot study, healthy humans were exposed to A. muciniphila for 2 h and colonic biopsies taken before and after colonic instillation for transcriptomic analysis. Seven days after colonic perforation, A.-muciniphila-treated mice had significantly lower mortality and severity of peritonitis. This effect was associated with significant improvements of wound histological healing scores, higher production of IL22, but no changes in the mucus layer thickness or genes involved in cell renewal, proliferation, or differentiation. All these effects were abolished in IEC-MyD88 KO mice. Finally, human subjects exposed to A. muciniphila exhibited an increased level of the bacterium at the mucus level 2 h after instillation and significant changes in the expression of different genes involved in the regulation of cell cycling, gene transcription, immunity, and inflammation in their colonic mucosa. A. muciniphila improves wound healing during transmural colonic wall defect through mechanisms possibly involving IL22 signaling and requiring MyD88 in the intestinal cells. In healthy humans, colonic administration of A. muciniphila is well tolerated and changes the expression of genes involved in the immune pathways.
650 7a NATURVETENSKAPx Biologix Immunologi0 (SwePub)106052 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Immunology0 (SwePub)106052 hsv//eng
653 a Akkermansia muciniphila
653 a Myd88
653 a colonic leakage
653 a peritonitis
653 a wound healing
7001 a Van Hul, Matthiasu Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life Sciences and BIOtechnology (WELBIO), UCLouvain, Université Catholique de Louvain, Brussels, Belgium4 aut
7001 a Baldin, Pamelau Pathology Department, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium4 aut
7001 a Léonard, Danielu Colorectal Surgery Unit, Cliniques Universitaires Saint-Luc, Brussels, Belgium4 aut
7001 a Delzenne, Nathalie M.u Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life Sciences and BIOtechnology (WELBIO), UCLouvain, Université Catholique de Louvain, Brussels, Belgium4 aut
7001 a Belzer, Clarau Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands4 aut
7001 a Ouwerkerk, Janneke P.u Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands4 aut
7001 a Repsilber, Dirk,d 1971-u Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre4 aut0 (Swepub:oru)drr
7001 a Rangel, Ignacio,d 1969-u Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre4 aut0 (Swepub:oru)irl
7001 a Kartheuser, Alexu Colorectal Surgery Unit, Cliniques Universitaires Saint-Luc, Brussels, Belgium4 aut
7001 a Brummer, Robert Jan,d 1957-u Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre4 aut0 (Swepub:oru)rnbr
7001 a De Vos, Willem M.u Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands; Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland4 aut
7001 a Cani, Patrice D.u Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life Sciences and BIOtechnology (WELBIO), UCLouvain, Université Catholique de Louvain, Brussels, Belgium4 aut
7102 a Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life Sciences and BIOtechnology (WELBIO), UCLouvain, Université Catholique de Louvain, Brussels, Belgium; Colorectal Surgery Unit, Cliniques Universitaires Saint-Luc, Brussels, Belgiumb Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life Sciences and BIOtechnology (WELBIO), UCLouvain, Université Catholique de Louvain, Brussels, Belgium4 org
7730 t Cellsd : MDPIg 11:17q 11:17x 2073-4409
8564 u https://doi.org/10.3390/cells11172666y Fulltext
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-101170
8564 8u https://doi.org/10.3390/cells11172666

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