WFRF:(Basik M)
Sökning: WFRF:(Basik M) > Tandoc K > An ErbB2/c-Src axis...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03333naa a2200661 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:141243324 | |
| 003 | SwePub | |
| 008 | 240920s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1412433242 URI |
| 024 | 7 | a https://doi.org/10.1038/s41467-019-10681-42 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Smith, HW4 aut |
| 245 | 1 0 | a An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis |
| 264 | c 2019-07-01 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2019 |
| 520 | a Dysregulation of histone modifications promotes carcinogenesis by altering transcription. Breast cancers frequently overexpress the histone methyltransferase EZH2, the catalytic subunit of Polycomb Repressor Complex 2 (PRC2). However, the role of EZH2 in this setting is unclear due to the context-dependent functions of PRC2 and the heterogeneity of breast cancer. Moreover, the mechanisms underlying PRC2 overexpression in cancer are obscure. Here, using multiple models of breast cancer driven by the oncogene ErbB2, we show that the tyrosine kinase c-Src links energy sufficiency with PRC2 overexpression via control of mRNA translation. By stimulating mitochondrial ATP production, c-Src suppresses energy stress, permitting sustained activation of the mammalian/mechanistic target of rapamycin complex 1 (mTORC1), which increases the translation of mRNAs encoding the PRC2 subunits Ezh2 and Suz12. We show that Ezh2 overexpression and activity are pivotal in ErbB2-mediated mammary tumourigenesis. These results reveal the hitherto unknown c-Src/mTORC1/PRC2 axis, which is essential for ErbB2-driven carcinogenesis. | |
| 700 | 1 | a Smith, HW4 aut |
| 700 | 1 | a Hirukawa, A4 aut |
| 700 | 1 | a Sanguin-Gendreau, V4 aut |
| 700 | 1 | a Nandi, I4 aut |
| 700 | 1 | a Dufour, CR4 aut |
| 700 | 1 | a Zuo, DM4 aut |
| 700 | 1 | a Tandoc, K4 aut |
| 700 | 1 | a Leibovitch, M4 aut |
| 700 | 1 | a Singh, S4 aut |
| 700 | 1 | a Rennhack, JP4 aut |
| 700 | 1 | a Swiatnicki, M4 aut |
| 700 | 1 | a Lavoie, C4 aut |
| 700 | 1 | a Papavasiliou, V4 aut |
| 700 | 1 | a Temps, C4 aut |
| 700 | 1 | a Carragher, NO4 aut |
| 700 | 1 | a Unciti-Broceta, A4 aut |
| 700 | 1 | a Savage, P4 aut |
| 700 | 1 | a Basik, M4 aut |
| 700 | 1 | a van Hoef, V4 aut |
| 700 | 1 | a Larsson, Ou Karolinska Institutet4 aut |
| 700 | 1 | a Cooper, CL4 aut |
| 700 | 1 | a Calderon, ACV4 aut |
| 700 | 1 | a Beith, J4 aut |
| 700 | 1 | a Millar, E4 aut |
| 700 | 1 | a Selinger, C4 aut |
| 700 | 1 | a Giguere, V4 aut |
| 700 | 1 | a Park, M4 aut |
| 700 | 1 | a Harris, LN4 aut |
| 700 | 1 | a Varadan, V4 aut |
| 700 | 1 | a Andrechek, ER4 aut |
| 700 | 1 | a O'Toole, SA4 aut |
| 700 | 1 | a Topisirovic, I4 aut |
| 700 | 1 | a Muller, WJ4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 10:1, s. 2901-q 10:1<2901-x 2041-1723 |
| 856 | 4 | u https://www.nature.com/articles/s41467-019-10681-4.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:141243324 |
| 856 | 4 8 | u https://doi.org/10.1038/s41467-019-10681-4 |
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- Hirukawa, A
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- Zuo, DM
- Tandoc, K
- Leibovitch, M
- Singh, S
- Rennhack, JP
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- Savage, P
- Basik, M
- van Hoef, V
- Larsson, O
- Cooper, CL
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- Selinger, C
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