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FältnamnIndikatorerMetadata
00018240naa a2201405 4500
001oai:prod.swepub.kib.ki.se:141248440
003SwePub
008240920s2019 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-440716
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1412484402 URI
024a https://doi.org/10.1038/s41398-018-0225-42 DOI
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4407162 URI
040 a (SwePub)kid (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Schwarz, Eu Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, Mannheim, Germany.,Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.4 aut
2451 0a Reproducible grey matter patterns index a multivariate, global alteration of brain structure in schizophrenia and bipolar disorder
264 c 2019-01-17
264 1b Springer Science and Business Media LLC,c 2019
520 a Schizophrenia is a severe mental disorder characterized by numerous subtle changes in brain structure and function. Machine learning allows exploring the utility of combining structural and functional brain magnetic resonance imaging (MRI) measures for diagnostic application, but this approach has been hampered by sample size limitations and lack of differential diagnostic data. Here, we performed a multi-site machine learning analysis to explore brain structural patterns of T1 MRI data in 2668 individuals with schizophrenia, bipolar disorder or attention-deficit/ hyperactivity disorder, and healthy controls. We found reproducible changes of structural parameters in schizophrenia that yielded a classification accuracy of up to 76% and provided discrimination from ADHD, through it lacked specificity against bipolar disorder. The observed changes largely indexed distributed grey matter alterations that could be represented through a combination of several global brain-structural parameters. This multi-site machine learning study identified a brain-structural signature that could reproducibly differentiate schizophrenia patients from controls, but lacked specificity against bipolar disorder. While this currently limits the clinical utility of the identified signature, the present study highlights that the underlying alterations index substantial global grey matter changes in psychotic disorders, reflecting the biological similarity of these conditions, and provide a roadmap for future exploration of brain structural alterations in psychiatric patients.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
700a Doan, NTu Norwegian Centre for Mental Disorders Research (NORMENT), KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway4 aut
700a Pergola, Gu Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy.,Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, KG Jebsen Ctr Psychosis Res,Div Mental Hlth & Add, Oslo, Norway.4 aut
700a Westlye, LTu Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, KG Jebsen Ctr Psychosis Res,Div Mental Hlth & Add, Oslo, Norway.;Univ Oslo, Dept Psychol, Oslo, Norway.4 aut
700a Kaufmann, Tu Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, KG Jebsen Ctr Psychosis Res,Div Mental Hlth & Add, Oslo, Norway.4 aut
700a Wolfers, Tu Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Donders Ctr Cognit Neuroimaging, Nijmegen, Netherlands.4 aut
700a Brecheisen, Ru Maastricht Univ, Med Ctr, Maastricht, Netherlands.4 aut
700a Quarto, Tu Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy.;Univ Helsinki, Dept Psychol & Logoped, Cognit Brain Res Unit, Fac Med, Helsinki, Finland.4 aut
700a Ing, AJu Kings Coll London, Ctr Populat Neurosci & Stratified Med PONS, London, England.;Kings Coll London, MRC SGDP Ctr, Inst Psychiat Psychol & Neurosci, London, England.,Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, KG Jebsen Ctr Psychosis Res,Div Mental Hlth & Add, Oslo, Norway.;Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm, Sweden.;Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway.4 aut
700a Di Carlo, Pu Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy.4 aut
700a Gurholt, TP4 aut
700a Harms, RLu Brain Innovat BV, Maastricht, Netherlands.,Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh EH10 5HF, Midlothian, Scotland.4 aut
700a Noirhomme, Qu Brain Innovat BV, Maastricht, Netherlands.4 aut
700a Moberget, Tu Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, KG Jebsen Ctr Psychosis Res,Div Mental Hlth & Add, Oslo, Norway.,Univ Southern Calif, Stevens Inst Neuroimaging & Informat, Imaging Genet Ctr, Los Angeles, CA USA.4 aut
700a Agartz, Iu Karolinska Institutet,Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, KG Jebsen Ctr Psychosis Res,Div Mental Hlth & Add, Oslo, Norway.;Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm, Sweden.;Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway.4 aut
700a Andreassen, OAu Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, KG Jebsen Ctr Psychosis Res,Div Mental Hlth & Add, Oslo, Norway.4 aut
700a Bellani, Mu Azienda Osped Univ Integrata Verona, Sect Psychiat, Verona, VR, Italy.;Univ Verona, Dept Neurosci Biomed & Movements Sci, Verona, VR, Italy.4 aut
700a Bertolino, Au Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy.;Azienda Osped Univ Consorziale Policlin Bari, Policlin Bari, Inst Psichiatry, Bari, BA, Italy.4 aut
700a Blasi, Gu Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy.;Azienda Osped Univ Consorziale Policlin, Bari, Italy.4 aut
700a Brambilla, Pu Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Neurosci & Mental Hlth, Milan, Italy.4 aut
700a Buitelaar, JKu Radboudumc, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.;Karakter Child & Adolescent Psychiat Univ Ctr, Nijmegen, Netherlands.4 aut
700a Cervenka, Simonu Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm, Sweden.4 aut0 (Swepub:uu)simce160
700a Flyckt, Lu Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm, Sweden.4 aut
700a Frangou, Su Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.4 aut
700a Franke, Bu Radboudumc, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Dept Psychiat, Med Ctr, Nijmegen, Netherlands.4 aut
700a Hall, Ju Cardiff Univ, Neurosci & Mental Hlth Res Inst, Maindy Rd, Cardiff CF24 4HQ, S Glam, Wales.4 aut
700a Heslenfeld, DJu Vrije Univ Amsterdam, Dept Cognit Psychol, Amsterdam, Netherlands.4 aut
700a Kirsch, Pu Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Clin Psychol, Heidelberg, Germany.;Bernstein Ctr Computat Neurosci Heidelberg Mannhe, Mannheim, Germany.4 aut
700a McIntosh, AMu Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh EH10 5HF, Midlothian, Scotland.;Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, George Sq, Edinburgh EH8 9JZ, Midlothian, Scotland.,Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.4 aut
700a Nothen, MMu Univ Bonn, Sch Med, Inst Human Genet, Bonn, Germany.;Univ Hosp Bonn, Bonn, Germany.;Univ Bonn, Dept Genom, Life & Brain Ctr, Bonn, Germany.4 aut
700a Papassotiropoulos, Au Univ Basel, Dept Psychol, Div Mol Neurosci, CH-4055 Basel, Switzerland.;Univ Basel, Transfac Res Platform Mol & Cognit Neurosci, Basel, Switzerland.;Univ Basel, Psychiat Univ Clin, CH-4055 Basel, Switzerland.;Univ Basel, Dept Biozentrum, Life Sci Training Facil, CH-4056 Basel, Switzerland.4 aut
700a de Quervain, DJFu Univ Basel, Transfac Res Platform Mol & Cognit Neurosci, Basel, Switzerland.;Univ Basel, Psychiat Univ Clin, CH-4055 Basel, Switzerland.;Univ Basel, Dept Psychol, Div Cognit Neurosci, CH-4055 Basel, Switzerland.,Univ Bonn, Dept Genom, Life & Brain Ctr, Bonn, Germany.,Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Genet Epidemiol Psychiat, Heidelberg, Germany.4 aut
700a Rietschel, Mu Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Genet Epidemiol Psychiat, Heidelberg, Germany.4 aut
700a Schumann, Gu Kings Coll London, Ctr Populat Neurosci & Stratified Med PONS, London, England.;Kings Coll London, MRC SGDP Ctr, Inst Psychiat Psychol & Neurosci, London, England.4 aut
700a Tost, Hu Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, Mannheim, Germany.4 aut
700a Witt, SHu Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Genet Epidemiol Psychiat, Heidelberg, Germany.,Univ Bonn, Sch Med, Inst Human Genet, Bonn, Germany.;Univ Hosp Bonn, Bonn, Germany.;Univ Bonn, Dept Genom, Life & Brain Ctr, Bonn, Germany.;Univ Basel, Dept Biomed, Basel, Switzerland.;Univ Basel, Inst Med Genet & Pathol, Human Genom Res Grp, Basel, Switzerland.;Univ Basel, Div Med Genet, Dept Biomed, Basel, Switzerland.;Univ Hosp Basel, Basel, Switzerland.4 aut
700a Zink, Mu Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, Mannheim, Germany.;Dist Hosp Mittelfranken, Dept Psychiat Psychotherapy & Psychosomat, Ansbach, Germany.4 aut
700a Meyer-Lindenberg, Au Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, Mannheim, Germany.4 aut
700a Bettella, Fu Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, KG Jebsen Ctr Psychosis Res,Div Mental Hlth & Add, Oslo, Norway.4 aut
700a Brandt, CLu Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, KG Jebsen Ctr Psychosis Res,Div Mental Hlth & Add, Oslo, Norway.4 aut
700a Clarke, TKu Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh EH10 5HF, Midlothian, Scotland.4 aut
700a Coynel, Du Univ Basel, Transfac Res Platform Mol & Cognit Neurosci, Basel, Switzerland.;Univ Basel, Dept Psychol, Div Cognit Neurosci, CH-4055 Basel, Switzerland.4 aut
700a Degenhardt, F4 aut
700a Djurovic, Su Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, KG Jebsen Ctr Psychosis Res,Div Mental Hlth & Add, Oslo, Norway.;Oslo Univ Hosp, Dept Med Genet, Oslo, Norway.4 aut
700a Eisenacher, Su Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, Mannheim, Germany.,Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, KG Jebsen Ctr Psychosis Res,Div Mental Hlth & Add, Oslo, Norway.,Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh EH10 5HF, Midlothian, Scotland.4 aut
700a Fastenrath, Mu Univ Basel, Transfac Res Platform Mol & Cognit Neurosci, Basel, Switzerland.;Univ Basel, Dept Psychol, Div Cognit Neurosci, CH-4055 Basel, Switzerland.4 aut
700a Fatouros-Bergman, Hu Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm, Sweden.4 aut
700a Forstner, AJu Univ Bonn, Sch Med, Inst Human Genet, Bonn, Germany.;Univ Hosp Bonn, Bonn, Germany.;Univ Bonn, Dept Genom, Life & Brain Ctr, Bonn, Germany.;Univ Basel, Dept Biomed, Human Genom Res Grp, Basel, Switzerland.;Univ Basel, Dept Psychiat UPK, Basel, Switzerland.;Univ Hosp Basel, Inst Med Genet & Pathol, Basel, Switzerland.4 aut
700a Frank, J4 aut
700a Gambi, Fu G DAnnunzio Univ Chieti Pescara, Dept Neurosci Imaging & Clin Sci, Pescara, Italy.4 aut
700a Gelao, Bu Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy.4 aut
700a Geschwind, Lu Univ Basel, Dept Psychol, Div Mol Neurosci, CH-4055 Basel, Switzerland.;Univ Basel, Transfac Res Platform Mol & Cognit Neurosci, Basel, Switzerland.4 aut
700a Di Giannantonio, Mu G DAnnunzio Univ Chieti Pescara, Dept Neurosci Imaging & Clin Sci, Pescara, Italy.;Natl Hlth Trust, Dept Mental Hlth, Chieti, Italy.4 aut
700a Di Giorgio, Au Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy.;Fdn Casa Sollievo Sofferenza IRCCS San Giovanni R, San Giovanni Rotondo, Italy.4 aut
700a Hartman, CAu Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot regulat, Dept Psychiat, Groningen, Netherlands.4 aut
700a Heilmann-Heimbach, Su Univ Bonn, Dept Genom, Life & Brain Ctr, Bonn, Germany.4 aut
700a Herms, S4 aut
700a Hoekstra, PJu Univ Groningen, Univ Med Ctr Groningen, Dept Child & Adolescent Psychiat, Groningen, Netherlands.4 aut
700a Hoffmann, Pu Univ Bonn, Sch Med, Inst Human Genet, Bonn, Germany.;Univ Hosp Bonn, Bonn, Germany.;Univ Bonn, Dept Genom, Life & Brain Ctr, Bonn, Germany.;Univ Basel, Dept Biomed, Basel, Switzerland.;Univ Basel, Inst Med Genet & Pathol, Human Genom Res Grp, Basel, Switzerland.;Univ Basel, Div Med Genet, Dept Biomed, Basel, Switzerland.;Univ Hosp Basel, Basel, Switzerland.4 aut
700a Hoogman, Mu Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, Nijmegen, Netherlands.;Radboudumc, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.4 aut
700a Jonsson, EGu Karolinska Institutet,Univ Oslo, Dept Psychol, Oslo, Norway.;Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm, Sweden.,Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.4 aut
700a Loos, Eu Univ Basel, Transfac Res Platform Mol & Cognit Neurosci, Basel, Switzerland.;Univ Basel, Dept Psychol, Div Cognit Neurosci, CH-4055 Basel, Switzerland.4 aut
700a Maggioni, Eu Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy.;Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Neurosci & Mental Hlth, Milan, Italy.4 aut
700a Oosterlaan, Ju Emma Childrens Hosp, Acad Med Ctr, Amsterdam, Netherlands.4 aut
700a Papalino, M4 aut
700a Rampino, Au Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy.4 aut
700a Romaniuk, L4 aut
700a Selvaggi, Pu Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy.;Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Neuroimaging, London, England.4 aut
700a Sepede, Gu Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy.;G DAnnunzio Univ Chieti Pescara, Dept Neurosci Imaging & Clin Sci, Pescara, Italy.4 aut
700a Sonderby, IE4 aut
700a Spalek, Ku Univ Basel, Transfac Res Platform Mol & Cognit Neurosci, Basel, Switzerland.;Univ Basel, Dept Psychol, Div Cognit Neurosci, CH-4055 Basel, Switzerland.4 aut
700a Sussmann, JE4 aut
700a Thompson, PM4 aut
700a Vasquez, AAu Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Dept Psychiat, Med Ctr, Nijmegen, Netherlands.4 aut
700a Vogler, Cu Univ Basel, Dept Psychol, Div Mol Neurosci, CH-4055 Basel, Switzerland.;Univ Basel, Transfac Res Platform Mol & Cognit Neurosci, Basel, Switzerland.4 aut
700a Whalley, Hu Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh EH10 5HF, Midlothian, Scotland.4 aut
700a Farde, Lu Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm, Sweden.4 aut
700a Flyckt, Lu Karolinska Institutet4 aut
700a Engberg, Gu Karolinska Institutet4 aut
700a Erhardt, Su Karolinska Institutet4 aut
700a Fatouros-Bergman, Hu Karolinska Institutet4 aut
700a Cervenka, Su Karolinska Institutet4 aut
700a Schwieler, Lu Karolinska Institutet,Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.4 aut
700a Agartz,4 aut
700a Collste, Ku Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm, Sweden.4 aut
700a Victorsson, Pu Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm, Sweden.4 aut
700a Malmqvist, Au Karolinska Institutet4 aut
700a Hedberg, Mu Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.4 aut
700a Orhan, Fu Karolinska Institutet,Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.4 aut
710a Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, Mannheim, Germany.b Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.4 org
773t Translational psychiatryd : Springer Science and Business Media LLCg 9:1, s. 12-q 9:1<12-x 2158-3188
856u https://www.nature.com/articles/s41398-018-0225-4.pdf
856u https://doi.org/10.1038/s41398-018-0225-4y Fulltext
856u https://uu.diva-portal.org/smash/get/diva2:1545864/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:141248440
8564 8u https://doi.org/10.1038/s41398-018-0225-4
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-440716

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