Sökning: WFRF:(Beloqui O.) > (2023) > Association of Inti...
Fältnamn | Indikatorer | Metadata |
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000 | 06356naa a2201201 4500 | |
001 | oai:gup.ub.gu.se/328132 | |
003 | SwePub | |
008 | 240528s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/3281322 URI |
024 | 7 | a https://doi.org/10.1161/jaha.122.0276572 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Tschiderer, L.4 aut |
245 | 1 0 | a Association of Intima-Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque: Individual Participant Data Meta-Analysis of 20 Prospective Studies |
264 | 1 | c 2023 |
520 | a BackgroundThe association between common carotid artery intima-media thickness (CCA-IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA-IMT and carotid plaque development. Methods and ResultsWe undertook an individual participant data meta-analysis of 20 prospective studies from the Proof-ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline CCA-IMT and incident carotid plaque involving 21 494 individuals without a history of cardiovascular disease and without preexisting carotid plaque at baseline. Mean baseline age was 56 years (SD, 9 years), 55% were women, and mean baseline CCA-IMT was 0.71 mm (SD, 0.17 mm). Over a median follow-up of 5.9 years (5th-95th percentile, 1.9-19.0 years), 8278 individuals developed first-ever carotid plaque. We combined study-specific odds ratios (ORs) for incident carotid plaque using random-effects meta-analysis. Baseline CCA-IMT was approximately log-linearly associated with the odds of developing carotid plaque. The age-, sex-, and trial arm-adjusted OR for carotid plaque per SD higher baseline CCA-IMT was 1.40 (95% CI, 1.31-1.50; I-2=63.9%). The corresponding OR that was further adjusted for ethnicity, smoking, diabetes, body mass index, systolic blood pressure, low- and high-density lipoprotein cholesterol, and lipid-lowering and antihypertensive medication was 1.34 (95% CI, 1.24-1.45; I-2=59.4%; 14 studies; 16 297 participants; 6381 incident plaques). We observed no significant effect modification across clinically relevant subgroups. Sensitivity analysis restricted to studies defining plaque as focal thickening yielded a comparable OR (1.38 [95% CI, 1.29-1.47]; I-2=57.1%; 14 studies; 17 352 participants; 6991 incident plaques). ConclusionsOur large-scale individual participant data meta-analysis demonstrated that CCA-IMT is associated with the long-term risk of developing first-ever carotid plaque, independent of traditional cardiovascular risk factors. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a carotid intima-media thickness | |
653 | a carotid plaque | |
653 | a individual participant | |
653 | a data meta-analysis | |
653 | a prospective studies | |
653 | a prevalent cardiovascular-disease | |
653 | a risk-factors | |
653 | a follow-up | |
653 | a atherosclerotic plaque | |
653 | a american society | |
653 | a vascular-disease | |
653 | a base-line | |
653 | a progression | |
653 | a ultrasound | |
653 | a determinants | |
653 | a Cardiovascular System & Cardiology | |
700 | 1 | a Seekircher, L.4 aut |
700 | 1 | a Izzo, R.4 aut |
700 | 1 | a Mancusi, C.4 aut |
700 | 1 | a Manzi, M. V.4 aut |
700 | 1 | a Baldassarre, D.4 aut |
700 | 1 | a Amato, M.4 aut |
700 | 1 | a Tremoli, E.4 aut |
700 | 1 | a Veglia, F.4 aut |
700 | 1 | a Tuomainen, T. P.4 aut |
700 | 1 | a Kauhanen, J.4 aut |
700 | 1 | a Voutilainen, A.4 aut |
700 | 1 | a Iglseder, B.4 aut |
700 | 1 | a Lind, L.4 aut |
700 | 1 | a Rundek, T.4 aut |
700 | 1 | a Desvarieux, M.4 aut |
700 | 1 | a Kato, A.4 aut |
700 | 1 | a de Groot, E.4 aut |
700 | 1 | a Asci, G.4 aut |
700 | 1 | a Ok, E.4 aut |
700 | 1 | a Agewall, S.4 aut |
700 | 1 | a Beulens, J. W. J.4 aut |
700 | 1 | a Byrne, C. D.4 aut |
700 | 1 | a Calder, P. C.4 aut |
700 | 1 | a Gerstein, H. C.4 aut |
700 | 1 | a Gresele, P.4 aut |
700 | 1 | a Klingenschmid, G.4 aut |
700 | 1 | a Nagai, M.4 aut |
700 | 1 | a Olsen, M. H.4 aut |
700 | 1 | a Parraga, G.4 aut |
700 | 1 | a Safarova, M. S.4 aut |
700 | 1 | a Sattar, N.4 aut |
700 | 1 | a Skilton, M.4 aut |
700 | 1 | a Stehouwer, C. D. A.4 aut |
700 | 1 | a Uthoff, H.4 aut |
700 | 1 | a van Agtmael, M. A.4 aut |
700 | 1 | a van der Heijden, A. A.4 aut |
700 | 1 | a Zozulinska-Ziolkiewicz, D. A.4 aut |
700 | 1 | a Park, H. W.4 aut |
700 | 1 | a Lee, M. S.4 aut |
700 | 1 | a Bae, J. H.4 aut |
700 | 1 | a Beloqui, O.4 aut |
700 | 1 | a Landecho, M. F.4 aut |
700 | 1 | a Plichart, M.4 aut |
700 | 1 | a Ducimetiere, P.4 aut |
700 | 1 | a Empana, J. P.4 aut |
700 | 1 | a Bokemark, Lena,d 1960u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xbokle |
700 | 1 | a Bergström, Göran,d 1964u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xbgort |
700 | 1 | a Schmidt, Caroline,d 1966u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xschca |
700 | 1 | a Castelnuovo, S.4 aut |
700 | 1 | a Calabresi, L.4 aut |
700 | 1 | a Norata, G. D.4 aut |
700 | 1 | a Grigore, L.4 aut |
700 | 1 | a Catapano, A.4 aut |
700 | 1 | a Zhao, D.4 aut |
700 | 1 | a Wang, M.4 aut |
700 | 1 | a Liu, J.4 aut |
700 | 1 | a Ikram, M. A.4 aut |
700 | 1 | a Kavousi, M.4 aut |
700 | 1 | a Bots, M. L.4 aut |
700 | 1 | a Sweeting, M. J.4 aut |
700 | 1 | a Lorenz, M. W.4 aut |
700 | 1 | a Willeit, P.4 aut |
710 | 2 | a Göteborgs universitetb Wallenberglaboratoriet4 org |
773 | 0 | t Journal of the American Heart Association (JAHA)g 12:12q 12:12x 2047-9980 |
856 | 4 8 | u https://gup.ub.gu.se/publication/328132 |
856 | 4 8 | u https://doi.org/10.1161/jaha.122.027657 |
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