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Sökning: WFRF:(Beloqui O.) > (2023) > Association of Inti...

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FältnamnIndikatorerMetadata
00006356naa a2201201 4500
001oai:gup.ub.gu.se/328132
003SwePub
008240528s2023 | |||||||||||000 ||eng|
024a https://gup.ub.gu.se/publication/3281322 URI
024a https://doi.org/10.1161/jaha.122.0276572 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Tschiderer, L.4 aut
2451 0a Association of Intima-Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque: Individual Participant Data Meta-Analysis of 20 Prospective Studies
264 1c 2023
520 a BackgroundThe association between common carotid artery intima-media thickness (CCA-IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA-IMT and carotid plaque development. Methods and ResultsWe undertook an individual participant data meta-analysis of 20 prospective studies from the Proof-ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline CCA-IMT and incident carotid plaque involving 21 494 individuals without a history of cardiovascular disease and without preexisting carotid plaque at baseline. Mean baseline age was 56 years (SD, 9 years), 55% were women, and mean baseline CCA-IMT was 0.71 mm (SD, 0.17 mm). Over a median follow-up of 5.9 years (5th-95th percentile, 1.9-19.0 years), 8278 individuals developed first-ever carotid plaque. We combined study-specific odds ratios (ORs) for incident carotid plaque using random-effects meta-analysis. Baseline CCA-IMT was approximately log-linearly associated with the odds of developing carotid plaque. The age-, sex-, and trial arm-adjusted OR for carotid plaque per SD higher baseline CCA-IMT was 1.40 (95% CI, 1.31-1.50; I-2=63.9%). The corresponding OR that was further adjusted for ethnicity, smoking, diabetes, body mass index, systolic blood pressure, low- and high-density lipoprotein cholesterol, and lipid-lowering and antihypertensive medication was 1.34 (95% CI, 1.24-1.45; I-2=59.4%; 14 studies; 16 297 participants; 6381 incident plaques). We observed no significant effect modification across clinically relevant subgroups. Sensitivity analysis restricted to studies defining plaque as focal thickening yielded a comparable OR (1.38 [95% CI, 1.29-1.47]; I-2=57.1%; 14 studies; 17 352 participants; 6991 incident plaques). ConclusionsOur large-scale individual participant data meta-analysis demonstrated that CCA-IMT is associated with the long-term risk of developing first-ever carotid plaque, independent of traditional cardiovascular risk factors.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a carotid intima-media thickness
653 a carotid plaque
653 a individual participant
653 a data meta-analysis
653 a prospective studies
653 a prevalent cardiovascular-disease
653 a risk-factors
653 a follow-up
653 a atherosclerotic plaque
653 a american society
653 a vascular-disease
653 a base-line
653 a progression
653 a ultrasound
653 a determinants
653 a Cardiovascular System & Cardiology
700a Seekircher, L.4 aut
700a Izzo, R.4 aut
700a Mancusi, C.4 aut
700a Manzi, M. V.4 aut
700a Baldassarre, D.4 aut
700a Amato, M.4 aut
700a Tremoli, E.4 aut
700a Veglia, F.4 aut
700a Tuomainen, T. P.4 aut
700a Kauhanen, J.4 aut
700a Voutilainen, A.4 aut
700a Iglseder, B.4 aut
700a Lind, L.4 aut
700a Rundek, T.4 aut
700a Desvarieux, M.4 aut
700a Kato, A.4 aut
700a de Groot, E.4 aut
700a Asci, G.4 aut
700a Ok, E.4 aut
700a Agewall, S.4 aut
700a Beulens, J. W. J.4 aut
700a Byrne, C. D.4 aut
700a Calder, P. C.4 aut
700a Gerstein, H. C.4 aut
700a Gresele, P.4 aut
700a Klingenschmid, G.4 aut
700a Nagai, M.4 aut
700a Olsen, M. H.4 aut
700a Parraga, G.4 aut
700a Safarova, M. S.4 aut
700a Sattar, N.4 aut
700a Skilton, M.4 aut
700a Stehouwer, C. D. A.4 aut
700a Uthoff, H.4 aut
700a van Agtmael, M. A.4 aut
700a van der Heijden, A. A.4 aut
700a Zozulinska-Ziolkiewicz, D. A.4 aut
700a Park, H. W.4 aut
700a Lee, M. S.4 aut
700a Bae, J. H.4 aut
700a Beloqui, O.4 aut
700a Landecho, M. F.4 aut
700a Plichart, M.4 aut
700a Ducimetiere, P.4 aut
700a Empana, J. P.4 aut
700a Bokemark, Lena,d 1960u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xbokle
700a Bergström, Göran,d 1964u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xbgort
700a Schmidt, Caroline,d 1966u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xschca
700a Castelnuovo, S.4 aut
700a Calabresi, L.4 aut
700a Norata, G. D.4 aut
700a Grigore, L.4 aut
700a Catapano, A.4 aut
700a Zhao, D.4 aut
700a Wang, M.4 aut
700a Liu, J.4 aut
700a Ikram, M. A.4 aut
700a Kavousi, M.4 aut
700a Bots, M. L.4 aut
700a Sweeting, M. J.4 aut
700a Lorenz, M. W.4 aut
700a Willeit, P.4 aut
710a Göteborgs universitetb Wallenberglaboratoriet4 org
773t Journal of the American Heart Association (JAHA)g 12:12q 12:12x 2047-9980
8564 8u https://gup.ub.gu.se/publication/328132
8564 8u https://doi.org/10.1161/jaha.122.027657

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