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Sökning: WFRF:(Benamor Jouda) > Non-invasive predic...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005269naa a2200469 4500
001oai:DiVA.org:uu-409702
003SwePub
008200505s2020 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4097022 URI
0247 a https://doi.org/10.1016/j.snb.2020.1279322 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Saidi, Tariku Moulay Ismail Univ Meknes, Fac Sci, Dept Phys, Sensor Elect & Instrumentat Grp, BP 11201, Zitoune, Meknes, Morocco.;Moulay Ismail Univ Meknes, Fac Sci, Dept Phys, Biotechnol Agroalimentary & Biomed Anal Grp, BP 11201, Zitoune, Meknes, Morocco.4 aut
2451 0a Non-invasive prediction of lung cancer histological types through exhaled breath analysis by UV-irradiated electronic nose and GC/QTOF/MS
264 1b Elsevier BV,c 2020
338 a print2 rdacarrier
520 a Lung cancer (LC) is one of the most lethal diseases from the last decades. Accurate diagnosis of LC histology could lead to the prescription of personalized medical treatment to the affected subjects, which could reduce the mortality rate. We present here an experimental study performed in the pulmonology units of three hospitals from Morocco to non-invasively detect LC and predict LC histology via the analysis of the volatile organic compounds (VOCs) emitted through breathing. Gas chromatography coupled to a quadrupole time-of-flight mass spectrometer (GC/QTOF/MS) employed to detect the breath VOCs, revealed 30 discriminative VOCs in the breath of healthy subjects and LC patients; among them, 4 unique breath VOCs were found for the first time in the breath of LC patients, and could be used as new biomarkers for future LC diagnosis. Besides, an electronic nose (e-nose) system using a novel sensing technique in breath analysis, based on UV-irradiation of the gas sensors, was employed to characterize the overall composition of the collected breath samples, providing a satisfactory discrimination between the breath patterns of LC patients and healthy subjects. Importantly, the e-nose could further discriminate with high accuracy between the two types of LC (non-small cell LC and small cell LC), as well as between two of the major subtypes of non-small cell LC, namely squamous cell carcinoma (SCC) and adenocarcinoma (ADC). The reported results prove that breath analysis with chemical gas sensors and analytical techniques can provided an accurate mean for the non-invasive diagnosis of LC and LC histology.
650 7a TEKNIK OCH TEKNOLOGIERx Medicinteknikx Medicinsk laboratorie- och mätteknik0 (SwePub)206012 hsv//swe
650 7a ENGINEERING AND TECHNOLOGYx Medical Engineeringx Medical Laboratory and Measurements Technologies0 (SwePub)206012 hsv//eng
653 a Breath analysis
653 a Lung cancer
653 a Histology
653 a GC/QTOF/MS
653 a Electronic nose
653 a UV-irradiated WO3 sensors
7001 a Moufid, Mohammedu Moulay Ismail Univ Meknes, Fac Sci, Dept Phys, Sensor Elect & Instrumentat Grp, BP 11201, Zitoune, Meknes, Morocco.;Moulay Ismail Univ Meknes, Fac Sci, Dept Phys, Biotechnol Agroalimentary & Biomed Anal Grp, BP 11201, Zitoune, Meknes, Morocco.4 aut
7001 a de Jesus Beleno-Saenz, Kelvinu Univ Autonoma Caribe, Mechatron Engn Dept, Barranquilla, Colombia.;Univ Complutense Madrid, Dept Chem Engn, Madrid 28040, Spain.4 aut
7001 a Welearegay, Tesfalem Geremariamu Uppsala universitet,Fasta tillståndets fysik,Rovira & Virgili Univ, Dept Elect Elect & Automat Engn, Av Paisos Catalans 26, Tarragona 43007, Spain4 aut
7001 a El Bari, Nezhau Moulay Ismail Univ Meknes, Fac Sci, Dept Phys, Biotechnol Agroalimentary & Biomed Anal Grp, BP 11201, Zitoune, Meknes, Morocco.4 aut
7001 a Lisset Jaimes-Mogollon, Aylenu Univ Complutense Madrid, Dept Chem Engn, Madrid 28040, Spain.;Univ Pamplona, Fac Engn & Architecture, GISM Grp, Pamplona, Colombia.4 aut
7001 a Ionescu, Raduu Uppsala universitet,Fasta tillståndets fysik4 aut0 (Swepub:uu)radio285
7001 a Bourkadi, Jamal Eddineu Univ Mohammed 5, Moulay Youssef Univ Hosp, Resp Dept, Rabat 10000, Morocco.4 aut
7001 a Benamor, Joudau Univ Mohammed 5, Moulay Youssef Univ Hosp, Resp Dept, Rabat 10000, Morocco.4 aut
7001 a El Ftouh, Mustaphau Int Univ Rabat, Avicenna Univ Hosp, Pulm Unit, BP 6527, Rabat, Morocco.4 aut
7001 a Bouchikhi, Benachiru Moulay Ismail Univ Meknes, Fac Sci, Dept Phys, Sensor Elect & Instrumentat Grp, BP 11201, Zitoune, Meknes, Morocco.4 aut
7102 a Moulay Ismail Univ Meknes, Fac Sci, Dept Phys, Sensor Elect & Instrumentat Grp, BP 11201, Zitoune, Meknes, Morocco.;Moulay Ismail Univ Meknes, Fac Sci, Dept Phys, Biotechnol Agroalimentary & Biomed Anal Grp, BP 11201, Zitoune, Meknes, Morocco.b Univ Autonoma Caribe, Mechatron Engn Dept, Barranquilla, Colombia.;Univ Complutense Madrid, Dept Chem Engn, Madrid 28040, Spain.4 org
7730 t Sensors and actuators. B, Chemicald : Elsevier BVg 311q 311x 0925-4005x 1873-3077
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-409702
8564 8u https://doi.org/10.1016/j.snb.2020.127932

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