WFRF:(Benhamou Simone)
Sökning: WFRF:(Benhamou Simone) > (2007-2009) > A susceptibility lo...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05085naa a2201033 4500 | |
| 001 | oai:DiVA.org:umu-46004 | |
| 003 | SwePub | |
| 008 | 110825s2008 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-460042 URI |
| 024 | 7 | a https://doi.org/10.1038/nature068852 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Hung, Rayjean J4 aut |
| 245 | 1 0 | a A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25 |
| 264 | 1 | b Nature Publishing Group,c 2008 |
| 338 | a print2 rdacarrier | |
| 520 | a Lung cancer is the most common cause of cancer death worldwide, with over one million cases annually. To identify genetic factors that modify disease risk, we conducted a genome-wide association study by analysing 317,139 single-nucleotide polymorphisms in 1,989 lung cancer cases and 2,625 controls from six central European countries. We identified a locus in chromosome region 15q25 that was strongly associated with lung cancer (P = 9 x 10(-10)). This locus was replicated in five separate lung cancer studies comprising an additional 2,513 lung cancer cases and 4,752 controls (P = 5 x 10(-20) overall), and it was found to account for 14% (attributable risk) of lung cancer cases. Statistically similar risks were observed irrespective of smoking status or propensity to smoke tobacco. The association region contains several genes, including three that encode nicotinic acetylcholine receptor subunits (CHRNA5, CHRNA3 and CHRNB4). Such subunits are expressed in neurons and other tissues, in particular alveolar epithelial cells, pulmonary neuroendocrine cells and lung cancer cell lines, and they bind to N'-nitrosonornicotine and potential lung carcinogens. A non-synonymous variant of CHRNA5 that induces an amino acid substitution (D398N) at a highly conserved site in the second intracellular loop of the protein is among the markers with the strongest disease associations. Our results provide compelling evidence of a locus at 15q25 predisposing to lung cancer, and reinforce interest in nicotinic acetylcholine receptors as potential disease candidates and chemopreventative targets. | |
| 700 | 1 | a McKay, James D4 aut |
| 700 | 1 | a Gaborieau, Valerie4 aut |
| 700 | 1 | a Boffetta, Paolo4 aut |
| 700 | 1 | a Hashibe, Mia4 aut |
| 700 | 1 | a Zaridze, David4 aut |
| 700 | 1 | a Mukeria, Anush4 aut |
| 700 | 1 | a Szeszenia-Dabrowska, Neonilia4 aut |
| 700 | 1 | a Lissowska, Jolanta4 aut |
| 700 | 1 | a Rudnai, Peter4 aut |
| 700 | 1 | a Fabianova, Eleonora4 aut |
| 700 | 1 | a Mates, Dana4 aut |
| 700 | 1 | a Bencko, Vladimir4 aut |
| 700 | 1 | a Foretova, Lenka4 aut |
| 700 | 1 | a Janout, Vladimir4 aut |
| 700 | 1 | a Chen, Chu4 aut |
| 700 | 1 | a Goodman, Gary4 aut |
| 700 | 1 | a Field, John K4 aut |
| 700 | 1 | a Liloglou, Triantafillos4 aut |
| 700 | 1 | a Xinarianos, George4 aut |
| 700 | 1 | a Cassidy, Adrian4 aut |
| 700 | 1 | a McLaughlin, John4 aut |
| 700 | 1 | a Liu, Geoffrey4 aut |
| 700 | 1 | a Narod, Steven4 aut |
| 700 | 1 | a Krokan, Hans E4 aut |
| 700 | 1 | a Skorpen, Frank4 aut |
| 700 | 1 | a Elvestad, Maiken Bratt4 aut |
| 700 | 1 | a Hveem, Kristian4 aut |
| 700 | 1 | a Vatten, Lars4 aut |
| 700 | 1 | a Linseisen, Jakob4 aut |
| 700 | 1 | a Clavel-Chapelon, Françoise4 aut |
| 700 | 1 | a Vineis, Paolo4 aut |
| 700 | 1 | a Bueno-de-Mesquita, H Bas4 aut |
| 700 | 1 | a Lund, Eiliv4 aut |
| 700 | 1 | a Martinez, Carmen4 aut |
| 700 | 1 | a Bingham, Sheila4 aut |
| 700 | 1 | a Rasmuson, Torgnyu Umeå universitet,Onkologi4 aut0 (Swepub:umu)tora0001 |
| 700 | 1 | a Hainaut, Pierre4 aut |
| 700 | 1 | a Riboli, Elio4 aut |
| 700 | 1 | a Ahrens, Wolfgang4 aut |
| 700 | 1 | a Benhamou, Simone4 aut |
| 700 | 1 | a Lagiou, Pagona4 aut |
| 700 | 1 | a Trichopoulos, Dimitrios4 aut |
| 700 | 1 | a Holcátová, Ivana4 aut |
| 700 | 1 | a Merletti, Franco4 aut |
| 700 | 1 | a Kjaerheim, Kristina4 aut |
| 700 | 1 | a Agudo, Antonio4 aut |
| 700 | 1 | a Macfarlane, Gary4 aut |
| 700 | 1 | a Talamini, Renato4 aut |
| 700 | 1 | a Simonato, Lorenzo4 aut |
| 700 | 1 | a Lowry, Ray4 aut |
| 700 | 1 | a Conway, David I4 aut |
| 700 | 1 | a Znaor, Ariana4 aut |
| 700 | 1 | a Healy, Claire4 aut |
| 700 | 1 | a Zelenika, Diana4 aut |
| 700 | 1 | a Boland, Anne4 aut |
| 700 | 1 | a Delepine, Marc4 aut |
| 700 | 1 | a Foglio, Mario4 aut |
| 700 | 1 | a Lechner, Doris4 aut |
| 700 | 1 | a Matsuda, Fumihiko4 aut |
| 700 | 1 | a Blanche, Helene4 aut |
| 700 | 1 | a Gut, Ivo4 aut |
| 700 | 1 | a Heath, Simon4 aut |
| 700 | 1 | a Lathrop, Mark4 aut |
| 700 | 1 | a Brennan, Paul4 aut |
| 710 | 2 | a Umeå universitetb Onkologi4 org |
| 773 | 0 | t Natured : Nature Publishing Groupg 452:7187, s. 633-637q 452:7187<633-637x 0028-0836x 1476-4687 |
| 856 | 4 | u https://hal-cea.archives-ouvertes.fr/cea-00944415/file/Hung1.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-46004 |
| 856 | 4 8 | u https://doi.org/10.1038/nature06885 |
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