A proinflammatory peptide from herpes simplex virus type 2 glycoprotein G affects neutrophil, monocyte, and NK cell functions

Bellner, Lars, 1973 (författare): Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research,University of Gothenburg, Sweden

Bergh Thorén, Fredrik, 1976 (författare): Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology,University of Gothenburg, Sweden

Nygren, Erik, 1976 (författare): Gothenburg University,Göteborgs universitet,Institutionen för medicinsk mikrobiologi och immunologi,Institute of Medical Microbiology/Immunology,University of Gothenburg, Sweden

Liljeqvist, Jan-Åke, 1954 (författare): Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology,University of Gothenburg, Sweden

Karlsson, Anna, 1967 (författare): Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research,University of Gothenburg, Sweden

Eriksson, Kristina, 1962 (författare): Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research,University of Gothenburg, Sweden

(creator_code:org_t)

American Association of Immunologists, 2005
2005
Engelska.
Ingår i: J Immunol. - : American Association of Immunologists. ; 174:4, s. 2235-2241

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Abstract Ämnesord

Stäng

We have identified a synthetic peptide derived from the secreted portion of HSV type 2 glycoprotein G, denoted gG-2p20, which has proinflammatory properties in vitro. The gG-2p20 peptide, corresponding to aa 190-205 of glycoprotein G-2, was a chemoattractant for both monocytes and neutrophils in a dose-dependent fashion, and also induced the release of reactive oxygen from these cells. The receptor mediating the responses was identified as the formyl peptide receptor. The gG-2p20-induced activation of phagocytes had a profound impact on NK cell functions. The reactive oxygen species produced by gG-2p20-activated phagocytes both inhibited NK cell cytotoxicity and accelerated the apoptotic cell death in NK cell-enriched lymphocyte populations. Hence, we have for the first time been able to identify a potential function of the secreted portion of HSV-2 glycoprotein G. We propose that the proinflammatory gG-2p20 peptide identified could contribute to a reduced function and viability of NK cells during HSV-2 infection due to its ability to recruit and activate phagocytic cells.

Av författaren/redakt...: Bellner, Lars, 1 ...; Bergh Thorén, Fr ...; Nygren, Erik, 19 ...; Liljeqvist, Jan- ...; Karlsson, Anna, ...; Eriksson, Kristi ...

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