Search: WFRF:(Bhattacharya Romit)
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Risk factors for cl...
Risk factors for clonal hematopoiesis of indeterminate potential in people with HIV : a report from the REPRIEVE trial
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- Bhattacharya, Romit (author)
- Harvard Medical School,Broad Institute,Massachusetts General Hospital
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- Uddin, Md Mesbah (author)
- Broad Institute
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- Patel, Aniruddh P. (author)
- Broad Institute,Massachusetts General Hospital,Harvard Medical School
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- Niroula, Abhishek (author)
- Lund University,Lunds universitet,Hematogenomics,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Broad Institute,Dana-Farber Cancer Institute
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- Finneran, Phoebe (author)
- Massachusetts General Hospital
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- Bernardo, Rachel (author)
- Massachusetts General Hospital
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- Fitch, Kathleen V. (author)
- Harvard Medical School,Massachusetts General Hospital
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- Lu, Michael T. (author)
- Massachusetts General Hospital
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- Bloomfield, Gerald S. (author)
- Duke Clinical Research Institute (DCRI)
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- Malvestutto, Carlos (author)
- Ohio State University
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- Aberg, Judy A. (author)
- Icahn School of Medicine at Mount Sinai
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- Fichtenbaum, Carl J. (author)
- University of Cincinnati College of Medicine
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- Hornsby, Whitney (author)
- Massachusetts General Hospital
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Ribaudo, Heather J. (author)
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- Libby, Peter (author)
- Harvard Medical School
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- Ebert, Benjamin L. (author)
- Howard Hughes Medical Institute,Broad Institute,Dana-Farber Cancer Institute,Harvard Medical School
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- Zanni, Markella V. (author)
- Harvard Medical School,Massachusetts General Hospital
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- Douglas, Pamela S. (author)
- Duke Clinical Research Institute (DCRI)
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- Grinspoon, Steven K. (author)
- Harvard Medical School,Massachusetts General Hospital
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- Natarajan, Pradeep (author)
- Harvard Medical School,Massachusetts General Hospital,Broad Institute
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(creator_code:org_t)
- 2024
- 2024
- English 9 s.
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In: Blood Advances. - 2473-9529. ; 8:4, s. 959-967
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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Abstract
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- Clonal hematopoiesis of indeterminate potential (CHIP), the clonal expansion of myeloid cells with leukemogenic mutations, results in increased coronary artery disease (CAD) risk. CHIP is more prevalent among people with HIV (PWH), but the risk factors are unknown. CHIP was identified among PWH in REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) using whole-exome sequencing. Logistic regression was used to associate sociodemographic factors and HIV-specific factors with CHIP adjusting for age, sex, and smoking status. In the studied global cohort of 4486 PWH, mean age was 49.9 (standard deviation [SD], 6.4) years; 1650 (36.8%) were female; and 3418 (76.2%) were non-White. CHIP was identified in 223 of 4486 (4.97%) and in 38 of 373 (10.2%) among those aged ≥60 years. Age (odds ratio [OR], 1.07; 95% confidence interval [CI], 1.05-1.09; P < .0001) and smoking (OR, 1.37; 95% CI, 1.14-1.66; P < .001) associated with increased odds of CHIP. Globally, participants outside of North America had lower odds of CHIP including sub- Saharan Africa (OR, 0.57; 95% CI, 0.4-0.81; P = .0019), South Asia (OR, 0.45; 95% CI, 0.23-0.80; P = .01), and Latin America/Caribbean (OR, 0.56; 95% CI, 0.34-0.87; P = .014). Hispanic/Latino ethnicity (OR, 0.38; 95% CI, 0.23-0.54; P = .002) associated with significantly lower odds of CHIP. Among HIV-specific factors, CD4 nadir <50 cells/mm3 associated with a 1.9-fold (95% CI, 1.21-3.05; P = .006) increased odds of CHIP, with the effect being significantly stronger among individuals with short duration of antiretroviral therapy (ART; OR, 4.15; 95% CI, 1.51-11.1; P = .005) (Pinteraction= .0492). Among PWH at low-to-moderate CAD risk on stable ART, smoking, CD4 nadir, North American origin, and non-Hispanic ethnicity associated with increased odds of CHIP.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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- ref (subject category)
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Bhattacharya, Ro ...
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Uddin, Md Mesbah
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Patel, Aniruddh ...
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Niroula, Abhishe ...
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Finneran, Phoebe
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Bernardo, Rachel
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Fitch, Kathleen ...
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Lu, Michael T.
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Bloomfield, Gera ...
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Malvestutto, Car ...
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Aberg, Judy A.
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Fichtenbaum, Car ...
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Hornsby, Whitney
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Ribaudo, Heather ...
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Libby, Peter
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Ebert, Benjamin ...
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Zanni, Markella ...
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Douglas, Pamela ...
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Grinspoon, Steve ...
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Natarajan, Prade ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Blood Advances
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Lund University