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FältnamnIndikatorerMetadata
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009oai:DiVA.org:liu-141843
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-617012 URI
0247 a https://doi.org/10.1056/NEJMoa17064432 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1406492 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3364802 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1366788152 URI
0247 a https://lup.lub.lu.se/record/e4ba7cdd-12bf-4a3c-a9f5-319872ffbbb82 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1418432 URI
040 a (SwePub)orud (SwePub)umud (SwePub)uud (SwePub)kid (SwePub)lud (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Erlinge, D.u Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular Cardiology,Lund University Research Groups,Lund University, Sweden4 aut0 (Swepub:lu)kard-der
2451 0a Bivalirudin versus Heparin Monotherapy in Myocardial Infarction
264 1b Massachusetts Medical Society,c 2017
338 a print2 rdacarrier
500 a Funding agencies:AstraZeneca and the Medicines Company
500 a Funding Agencies|Swedish Heart-Lung Foundation; Swedish Research Council; AstraZeneca; Medicines Company; Swedish Foundation for Strategic Research (as part of the TOTAL-AMI project)
520 a Background The comparative efficacy of various anticoagulation strategies has not been clearly established in patients with acute myocardial infarction who are undergoing percutaneous coronary intervention (PCI) according to current practice, which includes the use of radial-artery access for PCI and administration of potent P2Y12 inhibitors without the planned use of glycoprotein IIb/IIIa inhibitors. Methods In this multicenter, randomized, registry-based, open-label clinical trial, we enrolled patients with either ST-segment elevation myocardial infarction (STEMI) or non-STEMI (NSTEMI) who were undergoing PCI and receiving treatment with a potent P2Y12 inhibitor (ticagrelor, prasugrel, or cangrelor) without the planned use of glycoprotein IIb/IIIa inhibitors. The patients were randomly assigned to receive bivalirudin or heparin during PCI, which was performed predominantly with the use of radial-artery access. The primary end point was a composite of death from any cause, myocardial infarction, or major bleeding during 180 days of follow-up. Results A total of 6006 patients (3005 with STEMI and 3001 with NSTEMI) were enrolled in the trial. At 180 days, a primary end-point event had occurred in 12.3% of the patients (369 of 3004) in the bivalirudin group and in 12.8% (383 of 3002) in the heparin group (hazard ratio, 0.96; 95% confidence interval [CI], 0.83 to 1.10; P=0.54). The results were consistent between patients with STEMI and those with NSTEMI and across other major subgroups. Myocardial infarction occurred in 2.0% of the patients in the bivalirudin group and in 2.4% in the heparin group (hazard ratio, 0.84; 95% CI, 0.60 to 1.19; P=0.33), major bleeding in 8.6% and 8.6%, respectively (hazard ratio, 1.00; 95% CI, 0.84 to 1.19; P=0.98), definite stent thrombosis in 0.4% and 0.7%, respectively (hazard ratio, 0.54; 95% CI, 0.27 to 1.10; P=0.09), and death in 2.9% and 2.8%, respectively (hazard ratio, 1.05; 95% CI, 0.78 to 1.41; P=0.76). Conclusions Among patients undergoing PCI for myocardial infarction, the rate of the composite of death from any cause, myocardial infarction, or major bleeding was not lower among those who received bivalirudin than among those who received heparin monotherapy. (Funded by the Swedish Heart-Lung Foundation and others; VALIDATE-SWEDEHEART ClinicalTrialsRegister.eu number, 2012-005260-10 ; ClinicalTrials.gov number, NCT02311231 .).
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
7001 a Omerovic, Elmiru Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.4 aut
7001 a Fröbert, Ole,d 1964-u Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology, Faculty of Health, Örebro University, Örebro, Sweden,Rebro Univ, Fac Hlth, Dept Cardiol, Orebro, Sweden.4 aut0 (Swepub:oru)oft
7001 a Linder, Rikardu Karolinska Institutet,Danderyd Hospital, Sweden4 aut
7001 a Danielewicz, Mikaelu PCI-Unit at Karlstad Hospital, Karlstad, Sweden,Karlstad Hosp, PCI Unit, Karlstad, Sweden.4 aut
7001 a Hamid, Mehmetu Department of Cardiology, Mälarsjukhuset, Eskilstuna, Sweden,Malarsjukhuset, Dept Cardiol, Eskilstuna, Sweden.4 aut
7001 a Swahn, Evau Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US4 aut0 (Swepub:liu)evasw45
7001 a Henareh, Loghmanu Karolinska Institutet,Karolinska University Hospital, Sweden4 aut
7001 a Wagner, H.u Department of Cardiology, Helsingborg Lasarett, Helsingborg, Sweden,Helsingborg Lasarett, Dept Cardiol, Helsingborg, Sweden.,Helsingborg Hospital4 aut0 (Swepub:lu)med-hkw
7001 a Hårdhammar, Peteru Department of Cardiology, Halmstad Hospital, Halmstad, Sweden,Halmstad Cty Hosp, Dept Cardiol, Halmstad, Sweden.,Halmstad County Hospital, Sweden4 aut
7001 a Sjögren, Iwaru Department of Cardiology, Falun Hospital, Falun, Sweden,Falun Cent Hosp, Dept Cardiol, Falun, Sweden.,Falun Central Hospital, Sweden4 aut
7001 a Stewart, Jasonu Department of Cardiology, Skaraborgs Hospital, Skövde, Sweden,Skaraborgs Hosp, Dept Cardiol, Skovde, Sweden.4 aut
7001 a Grimfjärd, Peru Department of Internal Medicine, Västmanlands Sjukhus, Västerås, Sweden,Vastmanlands Sjukhus, Dept Internal Med, Vasteras, Sweden.,Västmanland Hospital4 aut
7001 a Jensen, Jensu Umeå University,Karolinska Institute,Karolinska Institutet,Karolinska Institute, Sweden,Sunderby Sjukhus, Sweden,Umeå University, Sweden4 aut
7001 a Aasa, Mikaelu Department of Cardiology, Södersjukhuset AB, Stockholm, Sweden,Sodersjukhuset AB, Dept Cardiol, Stockholm, Sweden.,Stockholm South General Hospital4 aut
7001 a Robertsson, Lottau Department of Internal Medicine, Västmanlands Sjukhus, Västerås, Sweden,Sodra Alvsborgs Sjukhus, Dept Cardiol, Boras, Sweden.,South Elfsborg Hospital4 aut
7001 a Lindroos, Pontusu Department of Cardiology, Capio St. Görans Hospital, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Capio St Gorans Hosp, Dept Cardiol, Stockholm, Sweden.,Capio St. Görans Sjukhus4 aut
7001 a Haupt, Janu Department of Cardiology, Sunderby Sjukhus, Luleå, Sweden,Sunderby Hospital4 aut
7001 a Wikström, Helenau Department of Cardiology, Kristianstad Hospital, Kristianstad, Sweden,Kristianstad Hosp, Dept Cardiol, Kristianstad, Sweden.,Central Hospital Kristianstad4 aut
7001 a Ulvenstam, Andersu Umeå universitet,Avdelningen för medicin,Ostersund Hosp, Dept Cardiol, Ostersund, Sweden.,Östersund Hospital, Sweden4 aut0 (Swepub:umu)anul0039
7001 a Bhiladvala, P.u Lund University,Lunds universitet,Kardiologiska klinikens forskargrupp,Forskargrupper vid Lunds universitet,Cardiology Research Group,Lund University Research Groups,Lund University, Sweden4 aut0 (Swepub:lu)medf-pbh
7001 a Lindvall, Bou Department of Cardiology, Sundsvall Hospital, Sundsvall, Sweden,Sundsvall Hosp, Dept Cardiol, Sundsvall, Sweden.4 aut
7001 a Lundin, Andersu Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden,Lund Univ, Dept Cardiol Clin Sci, Lund, Sweden.4 aut
7001 a Tödt, T.u Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden,Sahlgrens University Hospital, Sweden,Örebro University, Sweden4 aut0 (Swepub:lu)med-ttt
7001 a Ioanes, Danu Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.4 aut
7001 a Råmunddal, Trulsu Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden4 aut
7001 a Kellerth, Thomasu Örebro University4 aut
7001 a Zagozdzon, Leszeku Örebro University,Örebro University, Sweden4 aut
7001 a Götberg, M.u Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden4 aut0 (Swepub:lu)kard-mgo
7001 a Andersson, Jonasu Umeå universitet,Kardiologi4 aut0 (Swepub:umu)joan0102
7001 a Angerås, Oskaru Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.4 aut
7001 a Östlund, Ollieu Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Uppsala University, Sweden4 aut0 (Swepub:uu)oos27600
7001 a Lagerqvist, Bo,d 1952-u Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala University Hospital,Uppsala University, Sweden4 aut0 (Swepub:uu)bolager
7001 a Held, Claes,d 1956-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,Uppsala University Hospital,Uppsala University, Sweden4 aut0 (Swepub:uu)clahe947
7001 a Wallentin, Lars,d 1943-u Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala University Hospital,Uppsala University, Sweden4 aut0 (Swepub:uu)larswall
7001 a Scherstén, F.u Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden4 aut0 (Swepub:lu)med-fds
7001 a Eriksson, Peteru Umeå University,Umeå universitet,Kardiologi,Umea Univ, Dept Cardiol, Umea, Sweden.,Umeå University, Sweden4 aut0 (Swepub:umu)ernper00
7001 a Koul, S.u Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular Cardiology,Lund University Research Groups,Lund University, Sweden4 aut0 (Swepub:lu)med-sku
7001 a James, Stefan,d 1964-u Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala University Hospital,Uppsala University, Sweden4 aut0 (Swepub:uu)stjam367
7001 a Linder, Robert,d 1981-u Umeå universitet,Lungmedicin4 aut0 (Swepub:umu)rotlir03
7001 a Abdel-Hamid, Mohamedu Mälar Hospital4 aut
7001 a Östlund, Olofu Uppsala University Hospital4 aut
7102 a Kardiologib Sektion II4 org
7730 t New England Journal of Medicined : Massachusetts Medical Societyg 377:12, s. 1132-1142q 377:12<1132-1142x 0028-4793x 1533-4406
8564 u http://dx.doi.org/10.1056/NEJMoa1706443y FULLTEXT
8564 u https://liu.diva-portal.org/smash/get/diva2:1147969/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-61701
8564 8u https://doi.org/10.1056/NEJMoa1706443
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-140649
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-336480
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:136678815
8564 8u https://lup.lub.lu.se/record/e4ba7cdd-12bf-4a3c-a9f5-319872ffbbb8
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-141843

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