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Sökning: WFRF:(Birner A) > (2014) > Variations of disse...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003228naa a2200409 4500
001oai:DiVA.org:kth-140824
003SwePub
008140131s2014 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-1408242 URI
0247 a https://doi.org/10.1016/j.jbiomech.2013.10.0272 DOI
040 a (SwePub)kth
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Tong, J.4 aut
2451 0a Variations of dissection properties and mass fractions with thrombus age in human abdominal aortic aneurysms
264 1b Elsevier BV,c 2014
338 a print2 rdacarrier
500 a QC 20140204
520 a Introduction: Thrombus ages, defined as four relative age phases, are related to different compositions of the intraluminal thrombus (ILT) in the abdominal aortic aneurysm (AAA) (Tong et al., 2011b). Experimental studies indicate a correlation between the relative thrombus age and the strength of the thrombus-covered wall. Methods: On 32 AAA samples we performed peeling tests with the aim to dissect the material (i) through the ILT thickness, (ii) within the individual ILT layers and (iii) within the aneurysm wall underneath the thrombus by using two extension rates (1. mm/min, 1. mm/s). Histological investigations and mass fraction analysis were performed to characterize the dissected morphology, to determine the relative thrombus age, and to quantify dry weight percentages of elastin and collagen in the AAA wall. Results: A remarkably lower dissection energy was needed to dissect within the individual ILT layers and through the thicknesses of old thrombi. With increasing ILT age the dissection energy of the underlying intima-media composite continuously decreased and the anisotropic dissection properties for that composite vanished. The quantified dissection properties were rate dependent for both tissue types (ILT and wall). Histology showed that single fibrin fibers or smaller protein clots within the ILT generate smooth dissected surfaces during the peeling. There was a notable decrease in mass fraction of elastin within the thrombus-covered intima-media composite with ILT age, whereas no significant change was found for that of collagen. Conclusions: These findings suggest that intraluminal thrombus aging leads to a higher propensity of dissection for the ILT and the intima-media composite of the aneurysmal wall.
653 a Dissection
653 a Intraluminal thrombus
653 a Mass fraction
653 a Thrombus age
653 a Thrombus-covered wall
7001 a Cohnert, T.4 aut
7001 a Regitnig, P.4 aut
7001 a Kohlbacher, J.4 aut
7001 a Birner-Gruenberger, R.4 aut
7001 a Schriefl, A. J.4 aut
7001 a Sommer, G.4 aut
7001 a Holzapfel, Gerhard A.u KTH,Hållfasthetslära (Inst.)4 aut0 (Swepub:kth)u1esp3uu
7102 a KTHb Hållfasthetslära (Inst.)4 org
7730 t Journal of Biomechanicsd : Elsevier BVg 47:1, s. 14-23q 47:1<14-23x 0021-9290x 1873-2380
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-140824
8564 8u https://doi.org/10.1016/j.jbiomech.2013.10.027

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