Oxygen targets and 6-month outcome after out of hospital cardiac arrest : a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial

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Fältnamn	Indikatorer	Metadata
000		13915naa a2201393 4500
001		oai:lup.lub.lu.se:4949a1e5-f4a6-4606-88ef-9290ff027aee
003		SwePub
008		221124s2022 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:liu-189768
009		oai:prod.swepub.kib.ki.se:150994898
009		oai:gup.ub.gu.se/322298
024	7	a https://lup.lub.lu.se/record/4949a1e5-f4a6-4606-88ef-9290ff027aee2 URI
024	7	a https://doi.org/10.1186/s13054-022-04186-82 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1897682 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1509948982 URI
024	7	a https://gup.ub.gu.se/publication/3222982 URI
040		a (SwePub)lud (SwePub)liud (SwePub)kid (SwePub)gu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Robba, Chiarau University of Genoa,San Martino Policlin Hosp, Italy; Univ Genoa, Italy4 aut
245	1 0	a Oxygen targets and 6-month outcome after out of hospital cardiac arrest : a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial
264		c 2022-10-21
264	1	b Springer Science and Business Media LLC,c 2022
500		a Funding Agencies\|Swedish Research Council [Vetenskapsradet]; Swedish Heart-Lung Foundation; Knutsson Foundation; Stig and Ragna Gorthon Foundation; Laerdal Foundation; Hans-Gabriel and Alice Trolle-Wachtmeister Foundation for Medical Research; Regional Research Support in Region Skane); Swedish National Health Service
520		a Background: Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the values of partial pressure of oxygen values (PaO2) and the episodes of hypoxemia and hyperoxemia occurring within the first 72 h of mechanical ventilation in out of hospital cardiac arrest (OHCA) patients. The secondary aim was to evaluate the association of PaO2 with patients’ outcome. Methods: Preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after OHCA (TTM2) trial. Arterial blood gases values were collected from randomization every 4 h for the first 32 h, and then, every 8 h until day 3. Hypoxemia was defined as PaO2 < 60 mmHg and severe hyperoxemia as PaO2 > 300 mmHg. Mortality and poor neurological outcome (defined according to modified Rankin scale) were collected at 6 months. Results: 1418 patients were included in the analysis. The mean age was 64 ± 14 years, and 292 patients (20.6%) were female. 24.9% of patients had at least one episode of hypoxemia, and 7.6% of patients had at least one episode of severe hyperoxemia. Both hypoxemia and hyperoxemia were independently associated with 6-month mortality, but not with poor neurological outcome. The best cutoff point associated with 6-month mortality for hypoxemia was 69 mmHg (Risk Ratio, RR = 1.009, 95% CI 0.93–1.09), and for hyperoxemia was 195 mmHg (RR = 1.006, 95% CI 0.95–1.06). The time exposure, i.e., the area under the curve (PaO2-AUC), for hyperoxemia was significantly associated with mortality (p = 0.003). Conclusions: In OHCA patients, both hypoxemia and hyperoxemia are associated with 6-months mortality, with an effect mediated by the timing exposure to high values of oxygen. Precise titration of oxygen levels should be considered in this group of patients. Trial registration: clinicaltrials.gov NCT02908308, Registered September 20, 2016.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Anestesi och intensivvård0 (SwePub)302012 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Anesthesiology and Intensive Care0 (SwePub)302012 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653		a Cardiac arrest
653		a Hyperoxemia
653		a Hypoxemia
653		a Mortality
653		a Neurological outcome
653		a Cardiac arrest; Hypoxemia; Hyperoxemia; Mortality; Neurological outcome
653		a arterial oxygen
653		a carbon-dioxide
653		a hyperoxia
653		a resuscitation
653		a association
653		a cardiopulmonary
653		a survival
653		a care
653		a prognostication
653		a epidemiology
653		a General & Internal Medicine
700	1	a Lilja, Giselau Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Brain Injury After Cardiac Arrest,Center for cardiac arrest,Lund University Research Groups,Skåne University Hospital,Lund Univ, Sweden4 aut0 (Swepub:lu)med-gal
700	1	a Friberg, Hansu Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,SWECRIT,Center for cardiac arrest,Lund University Research Groups,Lund Univ, Sweden4 aut0 (Swepub:lu)efor-hfr
700	1	a Chew, Michelle S.u Linköpings universitet,Linköping University,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, ANOPIVA US,Skåne University Hospital4 aut0 (Swepub:lu)med-ss16
700	1	a Unden, Johanu Lund University,Lunds universitet,Anestesiologi och intensivvård,Forskargrupper vid Lunds universitet,Anaesthesiology and Intensive Care Medicine,Lund University Research Groups,Halmstad County Hospital,Lund Univ, Sweden; Lund Univ, Sweden,Helsingborg Hospital4 aut0 (Swepub:lu)neur-jun
700	1	a Dankiewicz, Josefu Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Lund Univ, Sweden4 aut0 (Swepub:lu)med-jfd
700	1	a Nielsen, Niklasu Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,SEBRA Sepsis and Bacterial Resistance Alliance,Center for cardiac arrest,Lund University Research Groups,Helsingborg Hospital,Lund Univ, Sweden4 aut0 (Swepub:lu)med-nni
700	1	a Ebner, Florianu Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Kliniska Vetenskaper, Helsingborg,Institutionen för kliniska vetenskaper, Lund,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Sciences, Helsingborg,Department of Clinical Sciences, Lund,Helsingborg Hospital,Lund Univ, Sweden4 aut0 (Swepub:lu)med-foe
700	1	a Pelosi, Paolou University of Genoa,San Martino Policlin Hosp, Italy; Univ Genoa, Italy4 aut
700	1	a Cronberg, Tobiasu Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Brain Injury After Cardiac Arrest,Center for cardiac arrest,Lund University Research Groups4 cre0 (Swepub:lu)efor-tcr
700	1	a Erlinge, Davidu Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups4 cre0 (Swepub:lu)kard-der
700	1	a Levin, Helenau Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Center for cardiac arrest,Lund University Research Groups4 cre0 (Swepub:lu)ores-hal
700	1	a Nordberg, Peru Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 cre0 (Swepub:lu)pe5482no
700	1	a Ullén, Susannu Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 cre0 (Swepub:lu)su7040ul
700	1	a Palmér, Karolinau Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups4 cre0 (Swepub:lu)med-klc
700	1	a Karlsson, Ulla Brittu Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 cre0 (Swepub:lu)med-ukn
700	1	a Heissler, Simonu Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 cre0 (Swepub:lu)med-shi
700	1	a Ceric, Ameldinau Helsingborg Hospital4 cre0 (Swepub:lu)am1280bi
700	1	a Haxhija, Zanau Helsingborg Hospital4 cre0 (Swepub:lu)za1517ha
700	1	a Düring, Joachimu Skåne University Hospital4 cre0 (Swepub:lu)jo3421du
700	1	a Bergström, Mattiasu Skåne University Hospital4 cre0 (Swepub:lu)ma2685be
700	1	a Bohm, Mattiasu Skåne University Hospital4 cre0 (Swepub:lu)ma7548bo
700	1	a Didriksson, Ingridu Skåne University Hospital4 cre0 (Swepub:lu)in5403di
700	1	a Frid, Petreau Skåne University Hospital4 cre0 (Swepub:lu)med-ptf
700	1	a Heimburg, Katarinau Skåne University Hospital4 cre0 (Swepub:lu)ka7876he
700	1	a Lundberg, Oscaru Skåne University Hospital4 cre0 (Swepub:lu)os0356lu
700	1	a Hau, Stefan Olssonu Skåne University Hospital4 cre0 (Swepub:lu)med-sos
700	1	a Schmidbauer, Simonu Skåne University Hospital4 cre0 (Swepub:lu)med-ss16
700	1	a Borgquist, Olau Skåne University Hospital4 cre0 (Swepub:lu)med-oab
700	1	a Bjärnroos, Annau Skåne University Hospital4 cre0 (Swepub:lu)an3572bj
700	1	a Blennow Nordström, Eriku Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 cre0 (Swepub:lu)er0251bl
700	1	a Dragancea, Irinau Skåne University Hospital4 cre0 (Swepub:lu)med-idn
700	1	a Kander, Thomasu Skåne University Hospital4 cre0 (Swepub:lu)med-tkn
700	1	a Lybeck, Annau Skåne University Hospital4 cre0 (Swepub:lu)med-aly
700	1	a Mattiasson, Gustavu Skåne University Hospital4 cre0 (Swepub:lu)efor-gma
700	1	a Rundgren, Malinu Skåne University Hospital4 cre0 (Swepub:lu)med-mrg
700	1	a Westhall, Eriku Skåne University Hospital4 cre0 (Swepub:lu)med-erw
700	1	a Annborn, Martinu Helsingborg Hospital,Lund Univ, Sweden4 cre0 (Swepub:lu)med-ma2
700	1	a Andertun, Sarau Helsingborg Hospital4 cre0 (Swepub:lu)sa7042an
700	1	a Johnsson, Jesperu Karolinska Institutet4 cre0 (Swepub:lu)eng06jjo
700	1	a Unden, Johanu Helsingborg Hospital4 cre0 (Swepub:lu)neur-jun
700	1	a Wijdicks, Eelco F. M.4 cre
700	1	a Badenes, Rafaelu Univ Valencia, Spain; Univ Valencia, Spain4 aut
700	1	a Battaglini, Deniseu San Martino Policlin Hosp, Italy; Univ Barcelona, Spain4 aut
700	1	a Ball, Lorenzou San Martino Policlin Hosp, Italy; Univ Genoa, Italy4 aut
700	1	a Sanfilippo, Filippou AOU Policlin San Marco, Italy4 aut
700	1	a Brunetti, Ioleu San Martino Policlin Hosp, Italy4 aut
700	1	a Jakobsen, Janus Christianu Copenhagen Univ Hosp, Denmark; Univ Southern Denmark, Denmark4 aut
700	1	a Wendel-Garcia, Pedro Davidu Univ Hosp Zurich, Switzerland4 aut
700	1	a Eastwood, Glennu Monash Univ, Australia; Austin Hosp, Australia4 aut
700	1	a Thomas, Matthewu Univ Hosp Bristol NHS Fdn Trust, England4 aut
700	1	a Joannidis, Michaelu Med Univ Innsbruck, Austria4 aut
700	1	a Nichol, Alistairu Monash Univ, Australia4 aut
700	1	a Lundin, Andreasu Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård,Institute of Clinical Sciences, Department of Anesthesiology and Intensive care4 aut0 (Swepub:gu)xlandz
700	1	a Hollenberg, Jacobu Karolinska Inst, Sweden4 aut
700	1	a Hammond, Naomiu UNSW Sydney, Australia4 aut
700	1	a Saxena, Manoju St George Hosp, Australia4 aut
700	1	a Solar, Miroslavu Charles Univ Prague, Czech Republic; Univ Hosp Hradec Kralove, Czech Republic4 aut
700	1	a Taccone, Fabio Silviou Univ Libre Bruxelles, Belgium4 aut
700	1	a Grejs, Anders Mortenu Aarhus Univ Hosp, Denmark; Aarhus Univ, Denmark4 aut
710	2	a University of Genoab San Martino Policlin Hosp, Italy; Univ Genoa, Italy4 org
710	2	a TTM2 Trial collaborators
773	0	t Critical Cared : Springer Science and Business Media LLCg 26, s. 1-13q 26<1-13x 1364-8535x 1466-609X
856	4	u http://dx.doi.org/10.1186/s13054-022-04186-8x freey FULLTEXT
856	4	u https://liu.diva-portal.org/smash/get/diva2:1709139/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4 8	u https://lup.lub.lu.se/record/4949a1e5-f4a6-4606-88ef-9290ff027aee
856	4 8	u https://doi.org/10.1186/s13054-022-04186-8
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-189768
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:150994898
856	4 8	u https://gup.ub.gu.se/publication/322298

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Av författaren/redakt...: Robba, Chiara; Lilja, Gisela; Friberg, Hans; Chew, Michelle S ...; Unden, Johan; Dankiewicz, Jose ...; visa fler...; Nielsen, Niklas; Ebner, Florian; Pelosi, Paolo; Cronberg, Tobias; Erlinge, David; Levin, Helena; Nordberg, Per; Ullén, Susann; Palmér, Karolina; Karlsson, Ulla B ...; Heissler, Simon; Ceric, Ameldina; Haxhija, Zana; Düring, Joachim; Bergström, Matti ...; Bohm, Mattias; Didriksson, Ingr ...; Frid, Petrea; Heimburg, Katari ...; Lundberg, Oscar; Hau, Stefan Olss ...; Schmidbauer, Sim ...; Borgquist, Ola; Bjärnroos, Anna; Blennow Nordströ ...; Dragancea, Irina; Kander, Thomas; Lybeck, Anna; Mattiasson, Gust ...; Rundgren, Malin; Westhall, Erik; Annborn, Martin; Andertun, Sara; Johnsson, Jesper; Wijdicks, Eelco ...; Badenes, Rafael; Battaglini, Deni ...; Ball, Lorenzo; Sanfilippo, Fili ...; Brunetti, Iole; Jakobsen, Janus ...; Wendel-Garcia, P ...; Eastwood, Glenn; Thomas, Matthew; Joannidis, Micha ...; Nichol, Alistair; Lundin, Andreas; Hollenberg, Jaco ...; Hammond, Naomi; Saxena, Manoj; Solar, Miroslav; Taccone, Fabio S ...; Grejs, Anders Mo ...; visa färre...

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