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FältnamnIndikatorerMetadata
00018052naa a2201825 4500
001oai:DiVA.org:uu-316025
003SwePub
008170224s2017 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:135018685
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3160252 URI
024a https://doi.org/10.1161/CIRCRESAHA.116.3087652 DOI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1350186852 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Jones, Gregory T.u Univ Otago, Dept Surg, Dunedin 9054, New Zealand.4 aut
2451 0a Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci
264 1c 2017
338 a electronic2 rdacarrier
520 a Rationale: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci only explain a small proportion of the heritability of AAA. Objective: To identify additional AAA risk loci using data from all available genome-wide association studies. Methods and Results: Through a meta-analysis of 6 genome-wide association study data sets and a validation study totaling 10 204 cases and 107 766 controls, we identified 4 new AAA risk loci: 1q32.3 (SMYD2), 13q12.11 (LINC00540), 20q13.12 (near PCIF1/MMP9/ZNF335), and 21q22.2 (ERG). In various database searches, we observed no new associations between the lead AAA single nucleotide polymorphisms and coronary artery disease, blood pressure, lipids, or diabetes mellitus. Network analyses identified ERG, IL6R, and LDLR as modifiers of MMP9, with a direct interaction between ERG and MMP9. Conclusions: The 4 new risk loci for AAA seem to be specific for AAA compared with other cardiovascular diseases and related traits suggesting that traditional cardiovascular risk factor management may only have limited value in preventing the progression of aneurysmal disease.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a aortic aneurysm
653 a abdominal
653 a computational biology
653 a genetics
653 a genome-wide association study
653 a matrix metalloproteinases
653 a meta-analysis
700a Tromp, Gerardu Geisinger Hlth Syst, Sigfried & Janet Weis Ctr Res, Danville, PA USA.;Univ Stellenbosch, Dept Biomed Sci, Fac Med & Hlth Sci, Div Mol Biol & Human Genet, Tygerberg, South Africa.;deCODE Amgen, Reykjavik, Iceland.4 aut
700a Kuivaniemi, Helenau Geisinger Hlth Syst, Sigfried & Janet Weis Ctr Res, Danville, PA USA.;Univ Stellenbosch, Dept Biomed Sci, Fac Med & Hlth Sci, Div Mol Biol & Human Genet, Tygerberg, South Africa.4 aut
700a Gretarsdottir, Solveig4 aut
700a Baas, Annette F.u Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands.4 aut
700a Giusti, Bettiu Univ Florence, Careggi Hosp, Dept Expt & Clin Med, Atherothrombot Dis Ctr, Florence, Italy.4 aut
700a Strauss, Ewau Polish Acad Sci, Inst Human Genet, Fac Nucle Acid Funct, Poznan, Poland.;Poznan Univ Med Sci, Dept Gen & Vasc Surg, Poznan, Poland.4 aut
700a van't Hof, Femke N. G.4 aut
700a Webb, Thomas R.u Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Gen Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.4 aut
700a Erdman, Robertu Geisinger Hlth Syst, Sigfried & Janet Weis Ctr Res, Danville, PA USA.,Univ Pittsburgh, Sch Publ Hlth, Dept Human Genet, Pittsburgh, PA 15260 USA.4 aut
700a Ritchie, Marylyn D.u Geisinger Hlth Syst, Biomed & Translat Informat, Danville, PA USA.;Penn State Univ, University Pk, PA 16802 USA.4 aut
700a Elmore, James R.u Geisinger Med Ctr, Dept Vasc Surg, Danville, PA 17822 USA.4 aut
700a Verma, Anuragu Penn State Univ, University Pk, PA 16802 USA.4 aut
700a Pendergrass, Sarahu Geisinger Hlth Syst, Biomed & Translat Informat, Danville, PA USA.;Penn State Univ, University Pk, PA 16802 USA.4 aut
700a Kullo, Iftikhar J.u Mayo Clin Rochester, Rochester, MN USA.4 aut
700a Zy, Zi Yeu Mayo Clin Rochester, Rochester, MN USA.4 aut
700a Peissig, Peggy L.u Marshfield Clin Res Fdn, Marshfield, WI USA.,Wayne State Univ, Dept Neurol, Detroit, MI USA.4 aut
700a Gottesman, Omriu Icahn Sch Med Mt Sinai, New York, NY 10029 USA.4 aut
700a Verma, Shefali S.u Penn State Univ, University Pk, PA 16802 USA.4 aut
700a Malinowski, Jenniferu Karolinska Institutet,Vanderbilt Univ, 221 Kirkland Hall, Nashville, TN 37235 USA.4 aut
700a Rasmussen-Torvik, Laura J.u Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA.4 aut
700a Borthwick, Kenneth M.u Geisinger Hlth Syst, Sigfried & Janet Weis Ctr Res, Danville, PA USA.4 aut
700a Smelser, Diane T.u Geisinger Hlth Syst, Sigfried & Janet Weis Ctr Res, Danville, PA USA.4 aut
700a Crosslin, David R.u Univ Washington, Dept Biomed Informat & Med Educ, Seattle, WA 98195 USA.4 aut
700a de Andrade, Marizau Mayo Clin Rochester, Rochester, MN USA.4 aut
700a Ryer, Evan J.u Geisinger Med Ctr, Dept Vasc Surg, Danville, PA 17822 USA.4 aut
700a McCarty, Catherine A.u Essentia Inst Rural Hlth, Div Res, Duluth, MN USA.4 aut
700a Bottinger, Erwin P.u Icahn Sch Med Mt Sinai, New York, NY 10029 USA.4 aut
700a Pacheco, Jennifer A.u Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA.4 aut
700a Crawford, Dana C.u Case Western Reserve Univ, Cleveland, OH 44106 USA.4 aut
700a Carrell, David S.u Grp Hlth Res Inst, Seattle, WA USA.4 aut
700a Gerhard, Glenn S.u Temple Univ, Sch Med, Dept Med Genet & Mol Biochem, Philadelphia, PA 19122 USA.4 aut
700a Franklin, David P.u Mission Hlth Syst, Mission Clin, Asheville, NC USA.4 aut
700a Carey, David J.u Geisinger Hlth Syst, Sigfried & Janet Weis Ctr Res, Danville, PA USA.4 aut
700a Phillips, Victoria L.u Univ Otago, Dept Surg, Dunedin 9054, New Zealand.4 aut
700a Williams, Michael J. A.u Univ Otago, Dept Med, Dunedin, New Zealand.4 aut
700a Wei, Wenhuau Univ Otago, Dept Surg, Dunedin 9054, New Zealand.,Maastricht Univ, CAPHRI Res Sch, Eindhoven, Netherlands.;Catharina Hosp, Dept Vasc Surg, Eindhoven, Netherlands.,Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands.4 aut
700a Blair, Rossu Waikato Hosp, Hamilton, New Zealand.4 aut
700a Hill, Andrew A.u Auckland City Hosp, Auckland, New Zealand.4 aut
700a Vasudevan, Thodor M.u Waikato Hosp, Hamilton, New Zealand.4 aut
700a Lewis, David R.u Univ Otago, Dept Surg, Christchurch, New Zealand.4 aut
700a Thomson, Ian A.u Univ Otago, Dept Surg, Dunedin 9054, New Zealand.4 aut
700a Krysa, Jou Univ Otago, Dept Surg, Dunedin 9054, New Zealand.4 aut
700a Hill, Geraldine B.u Univ Otago, Dept Surg, Dunedin 9054, New Zealand.4 aut
700a Roake, Justinu Univ Otago, Dept Surg, Christchurch, New Zealand.4 aut
700a Merriman, Tony R.u Univ Otago, Dept Biochem, Dunedin, New Zealand.4 aut
700a Oszkinis, Grzegorzu Poznan Univ Med Sci, Dept Gen & Vasc Surg, Poznan, Poland.4 aut
700a Galora, Silviau deCODE Amgen, Reykjavik, Iceland.;Univ Florence, Careggi Hosp, Dept Expt & Clin Med, Atherothrombot Dis Ctr, Florence, Italy.4 aut
700a Saracini, Claudiau Univ Florence, Careggi Hosp, Dept Expt & Clin Med, Atherothrombot Dis Ctr, Florence, Italy.4 aut
700a Abbate, Rosannau Univ Florence, Careggi Hosp, Dept Expt & Clin Med, Atherothrombot Dis Ctr, Florence, Italy.4 aut
700a Pulli, Raffaeleu Univ Florence, Careggi Hosp, Dept Expt & Clin Med, Vasc Surg Unit, Florence, Italy.,Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Univ Leeds, Leeds Inst Cardiovasc & Metab Med, Leeds, W Yorkshire, England.4 aut
700a Pratesi, Carlou Univ Florence, Careggi Hosp, Dept Expt & Clin Med, Vasc Surg Unit, Florence, Italy.4 aut
700a Saratzis, Athanasios4 aut
700a Verissimo, Ana R.u Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Gen Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.4 aut
700a Bumpstead, Suzannahu Wellcome Trust Sanger Inst, Genet Complex Traits Humans Grp, Cambridge, England.4 aut
700a Badger, Stephen A.u Queens Univ Belfast, Sch Med, Belfast, Antrim, North Ireland.4 aut
700a Clough, Rachel E.u Kings Coll London, Dept Vasc Surg, London, England. Kings Coll London, British Heart Fdn Ctr Res Excellence, Cardiovasc Div, Dept Vasc Surg, London, England.4 aut
700a Cockerill, Gillianu St Georges Univ London, Dept Vasc Surg, London, England.4 aut
700a Hafez, Hanyu King Faisal Specialist Hosp & Res Ctr, Jeddah, Saudi Arabia.,Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Gen Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.,Chirurgencooperatie Oost Nederland, Enschede, Netherlands.4 aut
700a Scott, D. Julian A.u Univ Leeds, Leeds Inst Cardiovasc & Metab Med, Leeds, W Yorkshire, England.4 aut
700a Futers, T. Simonu Univ Leeds, Leeds Inst Cardiovasc & Metab Med, Leeds, W Yorkshire, England.4 aut
700a Romaine, Simon P. R.u Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Univ Leeds, Leeds Inst Cardiovasc & Metab Med, Leeds, W Yorkshire, England.4 aut
700a Bridge, Katherineu Univ Leeds, Leeds Inst Cardiovasc & Metab Med, Leeds, W Yorkshire, England.4 aut
700a Griffin, Kathryn J.u Univ Leeds, Leeds Inst Cardiovasc & Metab Med, Leeds, W Yorkshire, England.4 aut
700a Bailey, Marc A.u Univ Leeds, Leeds Inst Cardiovasc & Metab Med, Leeds, W Yorkshire, England.4 aut
700a Smith, Alberto4 aut
700a Thompson, Matthew M.u St Georges Univ London, Dept Vasc Surg, London, England.4 aut
700a van Bockxmeer, Frank M.u Univ Western Australia, Dept Surg, Crawley, Australia.4 aut
700a Matthiasson, Stefan E.u Laekning Med Clin, Reykjavik, Iceland.4 aut
700a Thorleifsson, Gudmar4 aut
700a Thorsteinsdottir, Unnuru deCODE Amgen, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.4 aut
700a Blankensteijn, Jan D.u Vrije Univ Amsterdam Med Ctr, Dept Vasc Surg, Amsterdam, Netherlands.4 aut
700a Teijink, Joep A. W.u Maastricht Univ, CAPHRI Res Sch, Eindhoven, Netherlands.;Catharina Hosp, Dept Vasc Surg, Eindhoven, Netherlands.4 aut
700a Wijmenga, Ciscau Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands.4 aut
700a de Graaf, Jacquelineu Radboud Univ Nijmegen, Med Ctr, Radboud Inst Hlth Sci, Nijmegen, Netherlands.4 aut
700a Kiemeney, Lambertus A.u Radboud Univ Nijmegen, Med Ctr, Radboud Inst Hlth Sci, Nijmegen, Netherlands.4 aut
700a Lindholt, Jes S.u Odense Univ Hosp, Dept Cardiothorac & Vasc Surg, Elitary Res Ctr Individualized Med Arterial Dis C, Odense, Denmark.4 aut
700a Hughes, Anne4 aut
700a Bradley, Declan T.u Queens Univ Belfast, Ctr Publ Hlth, Belfast, Antrim, North Ireland.4 aut
700a Stirrups, Kathleen4 aut
700a Golledge, Jonathanu James Cook Univ, Queensland Res Ctr Peripheral Vasc Dis, Vasc Biol Unit, Townsville, Qld, Australia.;James Cook Univ, Dept Vasc & Endovasc Surg, Townsville, Qld, Australia.;Townsville Hosp, Townsville, Qld, Australia.4 aut
700a Norman, Paul E.u Karolinska Institutet,Univ Western Australia, Dept Surg, Crawley, Australia.4 aut
700a Powell, Janet T.u Imperial Coll London, Dept Surg & Canc, London, England. UCL, Inst Cardiovasc Sci, Cardiovasc Genet, London, England.4 aut
700a Humphries, Steve E.4 aut
700a Hamby, Stephen E.4 aut
700a Goodall, Alison H.u Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Gen Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.4 aut
700a Nelson, Christopher P.u Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Gen Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.4 aut
700a Sakalihasan, Natziu Univ Liege, Surg Res Ctr, GIGA Cardiovasc Sci Unit, Liege, Belgium.4 aut
700a Courtois, Audreyu Univ Florence, Careggi Hosp, Dept Expt & Clin Med, Atherothrombot Dis Ctr, Florence, Italy.4 aut
700a Ferrell, Robert E.u Univ Pittsburgh, Sch Publ Hlth, Dept Human Genet, Pittsburgh, PA 15260 USA.4 aut
700a Eriksson, Peru Karolinska Inst, Dept Med, Ctr Mol Med, Atherosclerosis Res Unit, Stockholm, Sweden.4 aut
700a Folkersen, Lasseu Karolinska Inst, Dept Med, Ctr Mol Med, Atherosclerosis Res Unit, Stockholm, Sweden.;Tech Univ Denmark, Ctr Biol Sequence Anal, Copenhagen, Denmark.4 aut
700a Franco-Cereceda, Andersu Karolinska Institutet,Karolinska Inst, Dept Mol Med & Surg, Cardiothorac Surg Unit, Stockholm, Sweden.4 aut
700a Eicher, John D.u NHLBI, Ctr Populat Studies, Framingham Heart Study, Framingham, MA USA.4 aut
700a Johnson, Andrew D.u NHLBI, Ctr Populat Studies, Framingham Heart Study, Framingham, MA USA.4 aut
700a Betsholtz, Christeru Karolinska Institutet,Uppsala universitet,Vaskulärbiologi,Karolinska Inst, Dept Med Biochem & Biophys, Vasc Biol Unit, Stockholm, Sweden.4 aut0 (Swepub:uu)chbet517
700a Ruusalepp, Arnou deCODE Amgen, Reykjavik, Iceland.;Tartu Univ Hosp, Dept Cardiac Surg, Tartu, Estonia.;Clin Gene Networks AB, Stockholm, Sweden.4 aut
700a Franzen, Oscaru Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, Inst Genom & Multiscale Biol, New York, NY 10029 USA.;Clin Gene Networks AB, Stockholm, Sweden.4 aut
700a Schadt, Eric E.u Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, Inst Genom & Multiscale Biol, New York, NY 10029 USA.4 aut
700a Bjorkegren, Johan L. M.u Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, Inst Genom & Multiscale Biol, New York, NY 10029 USA.;Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden.;Univ Tartu, Inst Biomed & Translat Med, Dept Physiol, Tartu, Estonia.;Clin Gene Networks AB, Stockholm, Sweden.4 aut
700a Lipovich, Leonardu Wayne State Univ, Dept Neurol, Detroit, MI USA.,Paracelsus Med Univ Nuremberg, Dept Vasc & Endovasc Surg, Nurnberg, Germany.4 aut
700a Drolet, Anne M.u Wayne State Univ, Ctr Mol Med & Genet, Detroit, MI USA.4 aut
700a Verhoeven, Eric L.u Paracelsus Med Univ Nuremberg, Dept Vasc & Endovasc Surg, Nurnberg, Germany.4 aut
700a Zeebregts, Clark J.u Univ Groningen, Univ Med Ctr Groningen, Dept Surg, Div Vasc Surg, Groningen, Netherlands.4 aut
700a Geelkerken, Robert H.u Chirurgencooperatie Oost Nederland, Enschede, Netherlands.4 aut
700a van Sambeek, Marc R.u Catharina Hosp, Dept Vasc Surg, Eindhoven, Netherlands.4 aut
700a van Sterkenburg, Steven M.u TweeSteden Hosp, Dept Surg, Tilburg, Netherlands.;Rijnstate Ziekenhuis, Dept Vasc Surg, Arnhem, Netherlands.4 aut
700a de Vries, Jean-Paulu St Antonius Hosp, Dept Vasc Surg, Nieuwegein, Netherlands.4 aut
700a Stefansson, Kari4 aut
700a Thompson, John R.u Univ Leicester, Dept Hlth Sci, Leicester, Leics, England.4 aut
700a de Bakker, Paul I. W.u Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands.4 aut
700a Deloukas, Panosu Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England. Univ Cambridge, Dept Haematol, Cambridge, England.;King Abdulaziz Univ, Princess Al Jawhara Al Brahim Ctr Excellence Res, Jeddah, Saudi Arabia.4 aut
700a Sayers, Robert D.u Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.4 aut
700a Harrison, Seamus C.u Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.4 aut
700a van Rij, Andre M.u Univ Otago, Dept Surg, Dunedin 9054, New Zealand.4 aut
700a Samani, Nilesh J.u Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Gen Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.4 aut
700a Bown, Matthew J.u Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Gen Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.4 aut
710a Univ Otago, Dept Surg, Dunedin 9054, New Zealand.b Geisinger Hlth Syst, Sigfried & Janet Weis Ctr Res, Danville, PA USA.;Univ Stellenbosch, Dept Biomed Sci, Fac Med & Hlth Sci, Div Mol Biol & Human Genet, Tygerberg, South Africa.;deCODE Amgen, Reykjavik, Iceland.4 org
773t Circulation Researchg 120:2, s. 341-+q 120:2<341-+x 0009-7330x 1524-4571
856u https://uu.diva-portal.org/smash/get/diva2:1076926/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-316025
8564 8u https://doi.org/10.1161/CIRCRESAHA.116.308765
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:135018685

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Franzen, Oscar
Schadt, Eric E.
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de Vries, Jean-P ...
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Thompson, John R ...
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