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Sökning: WFRF:(Borglykke Anders) > Banasik Karina > The FOXO3A rs280229...

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FältnamnIndikatorerMetadata
00004156naa a2200421 4500
001oai:lup.lub.lu.se:3c58f0e8-decd-4a20-9ee6-5cc43f7e18ab
003SwePub
008160404s2011 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/17115852 URI
0247 a https://doi.org/10.1210/jc.2010-08812 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Banasik, Karina4 aut
2451 0a The FOXO3A rs2802292 G-Allele Associates with Improved Peripheral and Hepatic Insulin Sensitivity and Increased Skeletal Muscle-FOXO3A mRNA Expression in Twins.
264 1b The Endocrine Society,c 2011
520 a Objective: The minor G allele of FOXO3A rs2802292 has been associated with longevity. We aimed to investigate whether a phenotype related to healthy metabolic aging could be identified in individuals carrying the longevity-associated FOXO3A rs2802292 G allele. Research Design and Methods: rs2802292 was genotyped in a phenotypically well-characterized population of young and elderly twins (n = 190) and in the population-based Inter99 cohort (n = 5768). All participants underwent oral glucose tolerance tests, and the twin population was additionally examined with an iv glucose tolerance test and a hyperinsulinemic, euglycemic clamp. Basal and insulin-stimulated FOXO3A mRNA expression was assessed in skeletal muscle biopsies from the twin population. Results: In the twin sample, carriers of the minor G allele of rs2802292 showed reduced fasting plasma insulin [per allele effect (β) = -13% (-24; -1) (95% confidence interval), P = 0.03] and lower incremental area under the curve 0-120 min for insulin after an oral glucose load [β = -14% (-23; -), P = 0.005]. The G allele was associated with increased peripheral insulin action [glucose disposal rate clamp, β = 0.85 mg·kgfat-free mass(-1) · min(-1) (0.049; 1.64), P = 0.04] and lower hepatic insulin resistance index [β = -13% (-25; -1), P = 0.03]. Furthermore, carriers of the G allele had increased basal FOXO3A mRNA expression in skeletal muscle compared with T-allele carriers [β = 16% (0; 33), P = 0.047]. In the Inter99 sample, we found an association with reduced incremental area under the curve 0-120 min for insulin after an oral glucose load [β = -3% (-5; -0.07), P = 0.04], but this association was not significant after adjustment for body mass index. Conclusion: Our data indicate that the minor G allele of FOXO3A rs2802292 is associated with enhanced peripheral and hepatic insulin sensitivity in our small twin cohort, which may be mediated through increased FOXO3A mRNA expression, although no major metabolic impact of rs2802292 was found in the large Inter99 cohort.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Ribel-Madsen, Rasmus4 aut
7001 a Gjesing, Anette P4 aut
7001 a Wegner, Lise4 aut
7001 a Andersson, Åsa4 aut
7001 a Poulsen, Pernille4 aut
7001 a Borglykke, Anders4 aut
7001 a Witte, Daniel R4 aut
7001 a Pedersen, Oluf4 aut
7001 a Hansen, Torben4 aut
7001 a Vaag, Allanu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)med-ava
7102 a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org
7730 t The Journal of clinical endocrinology and metabolismd : The Endocrine Societyg 96, s. 119-124q 96<119-124x 1945-7197x 0021-972X
8564 u http://www.ncbi.nlm.nih.gov/pubmed/20881262?dopt=Abstracty FULLTEXT
8564 u http://dx.doi.org/10.1210/jc.2010-0881y FULLTEXT
8564 u https://academic.oup.com/jcem/article-pdf/96/1/E119/10746235/jcemE119.pdf
8564 8u https://lup.lub.lu.se/record/1711585
8564 8u https://doi.org/10.1210/jc.2010-0881

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