Sökning: WFRF:(Brüske Irene) > Holcatova Ivana > Stevens Victoria L > Large-scale associa...
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000 | 10962naa a2202125 4500 | |
001 | oai:DiVA.org:umu-137794 | |
003 | SwePub | |
008 | 170727s2017 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:b5f6bb50-9652-4fb7-821f-5e126bc11baa | |
009 | oai:prod.swepub.kib.ki.se:136091611 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1377942 URI |
024 | 7 | a https://doi.org/10.1038/ng.38922 DOI |
024 | 7 | a https://lup.lub.lu.se/record/b5f6bb50-9652-4fb7-821f-5e126bc11baa2 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1360916112 URI |
040 | a (SwePub)umud (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a McKay, James D.u International Agency for Research on Cancer, World Health Organization4 aut |
245 | 1 0 | a Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes |
264 | c 2017-06-12 | |
264 | 1 | b Nature Publishing Group,c 2017 |
338 | a print2 rdacarrier | |
520 | a Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genomewide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a Genome-wide association studies | |
653 | a Lung cancer | |
653 | a Transcriptomics | |
700 | 1 | a Hung, Rayjean J.u University of Toronto4 aut |
700 | 1 | a Han, Younghunu Dartmouth College4 aut |
700 | 1 | a Zong, Xuchenu University of Toronto4 aut |
700 | 1 | a Carreras-Torres, Robertu International Agency for Research on Cancer, World Health Organization4 aut |
700 | 1 | a Christiani, David C.u Harvard Medical School,Dartmouth College4 aut |
700 | 1 | a Caporaso, Neil E.u National Institutes of Health, United States4 aut |
700 | 1 | a Johansson, Mattiasu International Agency for Research on Cancer, World Health Organization4 aut |
700 | 1 | a Xiao, Xiangjunu Karolinska Institutet4 aut |
700 | 1 | a Li, Yafangu Dartmouth College4 aut |
700 | 1 | a Byun, Jinyoungu Dartmouth College4 aut |
700 | 1 | a Dunning, Alisonu University of Cambridge4 aut |
700 | 1 | a Pooley, Karen A.u University of Cambridge4 aut |
700 | 1 | a Qian, David C.4 aut |
700 | 1 | a Ji, Xuemeiu Dartmouth College4 aut |
700 | 1 | a Liu, Geoffreyu University of Toronto4 aut |
700 | 1 | a Timofeeva, Maria N.u International Agency for Research on Cancer, World Health Organization4 aut |
700 | 1 | a Bojesen, Stig E.u Copenhagen University Hospital4 aut |
700 | 1 | a Wu, Xifengu University of Texas4 aut |
700 | 1 | a Le Marchand, Loicu University of Hawaii Cancer Center4 aut |
700 | 1 | a Albanes, Demetriosu National Institutes of Health, United States4 aut |
700 | 1 | a Bickeböller, Heikeu University of Göttingen4 aut |
700 | 1 | a Aldrich, Melinda C.u Vanderbilt University Medical Center4 aut |
700 | 1 | a Bush, William S.u Case Western Reserve University4 aut |
700 | 1 | a Tardon, Adoninau University of Oviedo4 aut |
700 | 1 | a Rennert, Gadu Carmel Medical Center4 aut |
700 | 1 | a Teare, M. Dawnu University of Sheffield4 aut |
700 | 1 | a Field, John K.u University of Liverpool4 aut |
700 | 1 | a Kiemeney, Lambertus A.u Radboud University Medical Center4 aut |
700 | 1 | a Lazarus, Philipu Washington State University4 aut |
700 | 1 | a Haugen, Aageu National Institute of Occupational Health, Norway4 aut |
700 | 1 | a Lam, Stephenu British Columbia Cancer Agency4 aut |
700 | 1 | a Schabath, Matthew B.u H. Lee Moffitt Cancer Center & Research Institute4 aut |
700 | 1 | a Andrew, Angeline S.u Dartmouth College4 aut |
700 | 1 | a Shen, Hongbingu Nanjing Medical University4 aut |
700 | 1 | a Hong, Yun-Chulu Seoul National University4 aut |
700 | 1 | a Yuan, Jian-Minu University of Pittsburgh Cancer Institute4 aut |
700 | 1 | a Bertazzi, Pier Albertou University of Milan4 aut |
700 | 1 | a Pesatori, Angela C.u University of Milan4 aut |
700 | 1 | a Ye, Yuanqingu University of Texas4 aut |
700 | 1 | a Diao, Nancyu Harvard T.H. Chan School of Public Health4 aut |
700 | 1 | a Su, Liu Harvard T.H. Chan School of Public Health4 aut |
700 | 1 | a Zhang, Ruyangu Harvard T.H. Chan School of Public Health4 aut |
700 | 1 | a Brhane, Yonathanu University of Toronto4 aut |
700 | 1 | a Leighl, Natashau Princess Margaret Hospital University of Toronto4 aut |
700 | 1 | a Johansen, Jakob S.u Copenhagen University Hospital4 aut |
700 | 1 | a Mellemgaard, Anders4 aut |
700 | 1 | a Saliba, Walid4 aut |
700 | 1 | a Haiman, Christopher A.4 aut |
700 | 1 | a Wilkens, Lynne R.4 aut |
700 | 1 | a Fernandez-Somoano, Ana4 aut |
700 | 1 | a Fernandez-Tardon, Guillermo4 aut |
700 | 1 | a van der Heijden, Henricus F. M.4 aut |
700 | 1 | a Kim, Jin Hee4 aut |
700 | 1 | a Dai, Juncheng4 aut |
700 | 1 | a Hu, Zhibin4 aut |
700 | 1 | a Davies, Michael P. A.4 aut |
700 | 1 | a Marcus, Michael W.4 aut |
700 | 1 | a Brunnström, Hansu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-hsb |
700 | 1 | a Manjer, Jonasu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)smi-jma |
700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome |
700 | 1 | a Muller, David C.4 aut |
700 | 1 | a Overvad, Kim4 aut |
700 | 1 | a Trichopoulou, Antonia4 aut |
700 | 1 | a Tumino, Rosario4 aut |
700 | 1 | a Doherty, Jennifer A.4 aut |
700 | 1 | a Barnett, Matt P.4 aut |
700 | 1 | a Chen, Chu4 aut |
700 | 1 | a Goodman, Gary E.4 aut |
700 | 1 | a Cox, Angela4 aut |
700 | 1 | a Taylor, Fiona4 aut |
700 | 1 | a Woll, Penella4 aut |
700 | 1 | a Brüske, Irene4 aut |
700 | 1 | a Wichmann, H-Erich4 aut |
700 | 1 | a Manz, Judith4 aut |
700 | 1 | a Muley, Thomas R.4 aut |
700 | 1 | a Risch, Angela4 aut |
700 | 1 | a Rosenberger, Albert4 aut |
700 | 1 | a Grankvist, Kjellu Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)kjgr0002 |
700 | 1 | a Johansson, Mikaelu Umeå universitet,Institutionen för strålningsvetenskaper4 aut0 (Swepub:umu)mijo0025 |
700 | 1 | a Shepherd, Frances A.4 aut |
700 | 1 | a Tsao, Ming-Sound4 aut |
700 | 1 | a Arnold, Susanne M.4 aut |
700 | 1 | a Haura, Eric B.4 aut |
700 | 1 | a Bolca, Ciprian4 aut |
700 | 1 | a Holcatova, Ivana4 aut |
700 | 1 | a Janout, Vladimir4 aut |
700 | 1 | a Kontic, Milica4 aut |
700 | 1 | a Lissowska, Jolanta4 aut |
700 | 1 | a Mukeria, Anush4 aut |
700 | 1 | a Ognjanovic, Simona4 aut |
700 | 1 | a Orlowski, Tadeusz M.4 aut |
700 | 1 | a Scelo, Ghislaine4 aut |
700 | 1 | a Swiatkowska, Beata4 aut |
700 | 1 | a Zaridze, David4 aut |
700 | 1 | a Bakke, Per4 aut |
700 | 1 | a Skaug, Vidar4 aut |
700 | 1 | a Zienolddiny, Shanbeh4 aut |
700 | 1 | a Duell, Eric J.4 aut |
700 | 1 | a Butler, Lesley M.4 aut |
700 | 1 | a Koh, Woon-Puay4 aut |
700 | 1 | a Gao, Yu-Tang4 aut |
700 | 1 | a Houlston, Richard S.4 aut |
700 | 1 | a McLaughlin, John4 aut |
700 | 1 | a Stevens, Victoria L.4 aut |
700 | 1 | a Joubert, Philippe4 aut |
700 | 1 | a Lamontagne, Maxime4 aut |
700 | 1 | a Nickle, David C.4 aut |
700 | 1 | a Obeidat, Ma'en4 aut |
700 | 1 | a Timens, Wim4 aut |
700 | 1 | a Zhu, Bin4 aut |
700 | 1 | a Song, Leiu National Institutes of Health, United States4 aut0 (Swepub:lu)med-ls1 |
700 | 1 | a Kachuri, Linda4 aut |
700 | 1 | a Artigas, Maria Soler4 aut |
700 | 1 | a Tobin, Martin D.4 aut |
700 | 1 | a Wain, Louise V.4 aut |
700 | 1 | a Rafnar, Thorunn4 aut |
700 | 1 | a Thorgeirsson, Thorgeir E.4 aut |
700 | 1 | a Reginsson, Gunnar W.4 aut |
700 | 1 | a Stefansson, Kari4 aut |
700 | 1 | a Hancock, Dana B.4 aut |
700 | 1 | a Bierut, Laura J.4 aut |
700 | 1 | a Spitz, Margaret R.4 aut |
700 | 1 | a Gaddis, Nathan C.4 aut |
700 | 1 | a Lutz, Sharon M.4 aut |
700 | 1 | a Gu, Fangyi4 aut |
700 | 1 | a Johnson, Eric O.4 aut |
700 | 1 | a Kamal, Ahsan4 aut |
700 | 1 | a Pikielny, Claudio4 aut |
700 | 1 | a Zhu, Dakai4 aut |
700 | 1 | a Lindström, Sara4 aut |
700 | 1 | a Jiang, Xia4 aut |
700 | 1 | a Tyndale, Rachel F.4 aut |
700 | 1 | a Chenevix-Trench, Georgia4 aut |
700 | 1 | a Beesley, Jonathan4 aut |
700 | 1 | a Bossé, Yohan4 aut |
700 | 1 | a Chanock, Stephen4 aut |
700 | 1 | a Brennan, Paul4 aut |
700 | 1 | a Landi, Maria Teresa4 aut |
700 | 1 | a Amos, Christopher I.4 aut |
710 | 2 | a International Agency for Research on Cancer, World Health Organizationb University of Toronto4 org |
710 | 2 | a SpiroMeta Consortium |
773 | 0 | t Nature Geneticsd : Nature Publishing Groupg 49:7, s. 1126-1132q 49:7<1126-1132x 1061-4036x 1546-1718 |
856 | 4 | u https://europepmc.org/articles/pmc5510465?pdf=render |
856 | 4 | u http://dx.doi.org/10.1038/ng.3892y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-137794 |
856 | 4 8 | u https://doi.org/10.1038/ng.3892 |
856 | 4 8 | u https://lup.lub.lu.se/record/b5f6bb50-9652-4fb7-821f-5e126bc11baa |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:136091611 |
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