Inflammatory profiles relate to survival in subtypes of amyotrophic lateral sclerosis

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Inflammatory profiles relate to survival in subtypes of amyotrophic lateral sclerosis

Olesen, Mads Nikolaj (author)

Wuolikainen, Anna (author): Umeå universitet,Klinisk immunologi

Nilsson, Anna Christine (author)

Wirenfeldt, Martin (author)

Forsberg, Karin (author): Umeå universitet,Klinisk immunologi

Madsen, Jonna Skov (author)

Lillevang, Soeren Thue (author)

Brandslund, Ivan (author)

Andersen, Peter M., 1962- (author): Umeå universitet,Klinisk immunologi

Asgari, Nasrin (author)

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Wolters Kluwer, 2020
2020
English.
In: Neurology. - : Wolters Kluwer. - 2332-7812. ; 7:3

Related links:: https://doi.org/10.1...; show more...; https://umu.diva-por... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Objective: To investigate inflammatory cytokines in patients with motor neuron disease (MND) evaluating the putative contribution of amyotrophic lateral sclerosis (ALS)-causing gene variants.Methods: This study is a retrospective case series with prospective follow-up (1994–2016) of 248 patients with MND, of whom 164 had ALS who were screened for mutations in the genes for SOD1 and C9orf72. Paired CSF and plasma were collected at the diagnostic evaluation before treatment. A panel of cytokines were measured blindly via digital ELISA on the Simoa platform.Results: Time from disease onset to death was longer for patients with ALS-causing SOD1 mutations (mSOD1, n = 24) than those with C9orf72 hexanucleotide repeat expansion (C9orf72HRE) ALS (n = 19; q = 0.001) and other ALS (OALS) (n = 119; q = 0.0008). Patients with OALS had higher CSF tumor necrosis factor alpha (TNF-α) compared with those with C9orf72HRE ALS (q = 0.014). Patients with C9orf72HRE ALS had higher CSF interferon alpha compared with those with OALS and mSOD1 ALS (q = 0.042 and q = 0.042). In patients with ALS, the survival was negatively correlated with plasma interleukin (IL) 10 (hazard ratio [HR] 1.17, 95% CI 1.05–1.30). Plasma TNF-α, IL-10, and TNF-related apoptosis-inducing ligand (TRAIL) (HR 1.01 [1.00–1.02], 1.15 [1.02–1.30], and 1.01 [1.00–1.01], respectively) of patients with OALS, plasma IL-1β (HR 5.90 [1.27–27.5]) of patients with C9orf72HRE ALS, and CSF TRAIL (10.5 [1.12–98.6]) of patients with mSOD1 ALS all correlated negatively with survival.Conclusions: Differences in survival times in ALS subtypes were correlated with cytokine levels, suggesting specific immune responses related to ALS genetic variants.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)

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By the author/editor: Olesen, Mads Nik ...; Wuolikainen, Ann ...; Nilsson, Anna Ch ...; Wirenfeldt, Mart ...; Forsberg, Karin; Madsen, Jonna Sk ...; show more...; Lillevang, Soere ...; Brandslund, Ivan; Andersen, Peter ...; Asgari, Nasrin; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

Articles in the publication: Neurology

By the university: Umeå University

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