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Time to epileptifor...
Time to epileptiform activity and EEG background recovery are independent predictors after cardiac arrest
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- Westhall, E. (author)
- Lund University,Lunds universitet,Klinisk neurofysiologi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Neurophysiology,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Lund Univ, Sweden
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- Rosén, I. (author)
- Lund University,Lunds universitet,Klinisk neurofysiologi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Neurophysiology,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Lund Univ, Sweden
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- Rundgren, M. (author)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Lund Univ, Sweden
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- Bro-Jeppesen, J. (author)
- University of Copenhagen,Rigshosp, Denmark; Univ Copenhagen, Denmark
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- Kjaergaard, J. (author)
- University of Copenhagen,Rigshosp, Denmark; Univ Copenhagen, Denmark
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- Hassager, C. (author)
- University of Copenhagen,Rigshosp, Denmark; Univ Copenhagen, Denmark
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- Lindehammar, Hans (author)
- Linköpings universitet,Linköping University,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Neurofysiologiska kliniken US
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- Horn, J. (author)
- Academic Medical Center of University of Amsterdam (AMC),Univ Amsterdam, Netherlands
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- Ullén, S. (author)
- Skåne University Hospital,Skane Univ Hosp, Sweden
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- Nielsen, N. (author)
- Helsingborg Hospital,Helsingborg Hosp, Sweden
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- Friberg, H. (author)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Lund Univ, Sweden
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- Cronberg, T. (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Lund Univ, Sweden
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English 9 s.
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In: Clinical Neurophysiology. - : Elsevier BV. - 1388-2457 .- 1872-8952. ; 129:8, s. 1660-1668
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Objective: Investigate the temporal development of EEG and prognosis. Methods: Prospective observational substudy of the Target Temperature Management trial. Six sites performed simplified continuous EEG-monitoring (cEEG) on comatose patients after cardiac arrest, blinded to treating physicians. We determined time-points of recovery of a normal-voltage continuous background activity and the appearance of an epileptiform EEG, defined as abundant epileptiform discharges, periodic/rhythmic discharges or electrographic seizure activity. Results: 134 patients were included, 65 had a good outcome. Early recovery of continuous background activity (within 24 h) occurred in 72 patients and predicted good outcome since 55 (76%) had good outcome, increasing the odds for a good outcome seven times compared to a late background recovery. Early appearance of an epileptiform EEG occurred in 38 patients and 34 (89%) had a poor outcome, increasing the odds for a poor outcome six times compared to a late debut. The time to background recovery and the time to epileptiform activity were highly associated with outcome and levels of neuron-specific enolase. Multiple regression analysis showed that both variables were independent predictors. Conclusions: Time to epileptiform activity and background recovery are independent prognostic indicators. Significance: Patients with early background recovery combined with late appearance of epileptiform activity may have a good outcome.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Cardiac arrest
- Coma
- Continuous EEG monitoring
- EEG
- Prognosis
- Status epilepticus
- EEG; Continuous EEG monitoring; Prognosis; Status epilepticus; Coma; Cardiac arrest
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Westhall, E.
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Rosén, I.
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Rundgren, M.
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Bro-Jeppesen, J.
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Kjaergaard, J.
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Hassager, C.
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show more...
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Lindehammar, Han ...
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Horn, J.
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Ullén, S.
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Nielsen, N.
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Friberg, H.
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Cronberg, T.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Clinical Neuroph ...
- By the university
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Lund University
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Linköping University