Sökning: WFRF:(Brookes A) > Mälardalens universitet > Comprehensive genet...
Fältnamn | Indikatorer | Metadata |
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000 | 04647naa a2200481 4500 | |
001 | oai:DiVA.org:mdh-40725 | |
003 | SwePub | |
008 | 180906s2005 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-14471 | |
009 | oai:prod.swepub.kib.ki.se:1934655 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-407252 URI |
024 | 7 | a https://doi.org/10.1007/s00439-005-0060-62 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-144712 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19346552 URI |
040 | a (SwePub)mdhd (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Lindström, Sarau Umeå universitet,Onkologi4 aut0 (Swepub:umu)sralom02 |
245 | 1 0 | a Comprehensive genetic evaluation of common E-cadherin sequence variants and prostate cancer risk :b strong confirmation of functional promoter SNP |
264 | c 2005-09-28 | |
264 | 1 | a Umea Univ, Dept Radiat Sci, S-90187 Umea, Sweden. Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. Karolinska Inst, Ctr Genom & Bioinformat, Stockholm, Sweden. Univ Leicester, Dept Genet, Leicester LE1 7RH, Leics, England. Wake Forest Univ, Sch Med, Ctr Human Genom, Winston Salem, NC USA. Johns Hopkins Med Inst, Dept Urol, Baltimore, MD USA. CLINTECH, Karolinska Inst, Ctr Oncol, Stockholm, Sweden.b SPRINGER,c 2005 |
338 | a print2 rdacarrier | |
520 | a The E-cadherin gene (CDH1) has been proposed as a prostate cancer (PC) susceptibility gene in several studies. Aberrant protein expression has been related to prognosis and progression in PC. In addition, a functional promoter SNP (rsl6260) has been found to associate with PC risk. We performed a comprehensive genetic analysis of CDH1 by using the method of haplotype tagged SNPs in a large Swedish population-based case-control study consisting of 801 controls and 1,636 cases. In addition, Swedish PC families comprising a total of 157 cases sampled for DNA were analyzed for selected SNPs. Seven SNPs, including the promoter SNP rsl6260, that captured over 96% of CDH1 haplotype variation were selected as haplotype tagging SNPs and analyzed for associated PC risk. We observed significant confirmation of rsl6260 (P=0.003) for cases with a positive family history of PC (FH+) both in an independent case-control population and in PC families. In addition, a common haplotype (HapB, 25%) including the variant allele of rsl6260 was associated (P=0.004) with PC risk among FH+ cases. The promoter SNP rsl6260 as well as HapB were significantly transmitted to affected offspring in PC families. We report strong confirmation of the association between PC risk in FH+ cases and a functional CDH1 promoter SNP in an independent population. In conjunction with the biological importance of CDH1 our findings encourage further evaluation of genetic variation in CDH1 in relation to PC etiology. Due to the difficulties in replication of genetic association studies. this finding is unusual and novel. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskap0 (SwePub)3032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciences0 (SwePub)3032 hsv//eng |
700 | 1 | a Wiklund, Fu Karolinska Institutet,Umeå universitet,Onkologi4 aut |
700 | 1 | a Jonsson, B Au Karolinska Institutet,Umeå universitet,Onkologi4 aut |
700 | 1 | a Adami, H Ou Karolinska Institutet4 aut |
700 | 1 | a Bälter, Katarinau Karolinska Institutet4 aut0 (Swepub:mdh)kbr01 |
700 | 1 | a Brookes, A J4 aut |
700 | 1 | a Xu, J F4 aut |
700 | 1 | a Zheng, S L4 aut |
700 | 1 | a Isaacs, W B4 aut |
700 | 1 | a Adolfsson, J4 aut |
700 | 1 | a Gronberg, Hu Karolinska Institutet,Umeå universitet,Onkologi4 aut |
710 | 2 | a Umeå universitetb Onkologi4 org |
773 | 0 | t Human Geneticsd Umea Univ, Dept Radiat Sci, S-90187 Umea, Sweden. Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. Karolinska Inst, Ctr Genom & Bioinformat, Stockholm, Sweden. Univ Leicester, Dept Genet, Leicester LE1 7RH, Leics, England. Wake Forest Univ, Sch Med, Ctr Human Genom, Winston Salem, NC USA. Johns Hopkins Med Inst, Dept Urol, Baltimore, MD USA. CLINTECH, Karolinska Inst, Ctr Oncol, Stockholm, Sweden. : SPRINGERg 118:3-4, s. 339-347q 118:3-4<339-347x 0340-6717x 1432-1203 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-40725 |
856 | 4 8 | u https://doi.org/10.1007/s00439-005-0060-6 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-14471 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1934655 |
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