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Sökning: WFRF:(Bruening Thomas) > (2013) > Refereegranskat > N-acetyltransferase...

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FältnamnIndikatorerMetadata
00005807naa a2200877 4500
001oai:DiVA.org:umu-85563
003SwePub
008140206s2013 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:0dd16c6e-e0a1-40b6-a573-4ace7e21b55a
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-855632 URI
0247 a https://doi.org/10.1158/1055-9965.EPI-13-0119-T2 DOI
0247 a https://lup.lub.lu.se/record/42724622 URI
040 a (SwePub)umud (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Pesch, Beate4 aut
2451 0a N-acetyltransferase 2 Phenotype, Occupation, and Bladder Cancer Risk :b Results from the EPIC Cohort
264 1b American Association for Cancer Research,c 2013
338 a print2 rdacarrier
520 a Background: An association between N-acetyltransferase 2 (NAT2) slow acetylation and bladder cancer has been consistently observed in epidemiologic studies. However, evidence has been mainly derived from case-control studies and was sparse from cohort studies. We evaluated the association between NAT2 slow acetylation and bladder cancer in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition.Methods: Exposure to aromatic amines and polycyclic aromatic hydrocarbons (PAH) could be assessed for 754 cases and 833 controls for whom occupational information was documented. A semiquantitative job-exposure matrix was applied to at-risk occupations to estimate the exposure as low, medium, or high based on tertiles of the distribution of the exposure score in controls. Using a comprehensive genotyping, NAT2 acetylation status could be categorized from 6-single-nucleotide polymorphism genotypes as slow or fast in 607 cases and 695 controls with DNA from archived blood samples.Results: Occupational exposure to aromatic amines and PAH was associated with an increased bladder cancer risk [upper tertile of the distribution of the exposure score: OR = 1.37; 95% confidence interval (CI), 1.02-1.84, and OR = 1.50; 95% CI, 1.09-2.05, respectively]. NAT2 slow acetylation did not modify these risk estimates and was not itself associated with bladder cancer risk (OR = 1.02; 95% CI, 0.81-1.29).Conclusions: These findings confirm established or suspected occupational risk factors but not the anticipated role of NAT2 slow acetylation in bladder cancer. No interaction was detected between NAT2 and any exposure of interest, including smoking. Impact: Genetic testing for NAT2 would be inappropriate in occupational settings.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
7001 a Gawrych, Katarzyna4 aut
7001 a Rabstein, Sylvia4 aut
7001 a Weiss, Tobias4 aut
7001 a Casjens, Swaantje4 aut
7001 a Rihs, Hans-Peter4 aut
7001 a Ding, Hui4 aut
7001 a Angerer, Juergen4 aut
7001 a Illig, Thomas4 aut
7001 a Klopp, Norman4 aut
7001 a Bueno-de-Mesquita, Bas4 aut
7001 a Ros, Martine M.4 aut
7001 a Kaaks, Rudolf4 aut
7001 a Chang-Claude, Jenny4 aut
7001 a Roswall, Nina4 aut
7001 a Tjonneland, Anne4 aut
7001 a Overvad, Kim4 aut
7001 a Clavel-Chapelon, Francoise4 aut
7001 a Boutron-Ruault, Marie-Christine4 aut
7001 a Dossus, Laure4 aut
7001 a Boeing, Heiner4 aut
7001 a Weikert, Steffen4 aut
7001 a Trichopoulos, Dimitrios4 aut
7001 a Palli, Domenico4 aut
7001 a Sieri, Sabina4 aut
7001 a Tumino, Rosario4 aut
7001 a Panico, Salvatore4 aut
7001 a Ramon Quiros, Jose4 aut
7001 a Gonzalez, Carlos4 aut
7001 a Jose Sanchez, Maria4 aut
7001 a Dorronsoro, Miren4 aut
7001 a Navarro, Carmen4 aut
7001 a Barricarte, Aurelio4 aut
7001 a Ljungberg, Börjeu Umeå universitet,Urologi och andrologi,Njurcancer4 aut0 (Swepub:umu)bolj0001
7001 a Johansson, Mattiasu International Agency for Research on Cancer (IARC-WHO), Lyon, France4 aut0 (Swepub:umu)masmas97
7001 a Ulmert, Davidu Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)klke-dul
7001 a Ehrnström, Royu Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)pat-reh
7001 a Khaw, Kay-Tee4 aut
7001 a Wareham, Nick4 aut
7001 a Key, Timothy J.4 aut
7001 a Ferrari, Pietro4 aut
7001 a Romieu, Isabelle4 aut
7001 a Riboli, Elio4 aut
7001 a Bruening, Thomas4 aut
7001 a Vineis, Paolo4 aut
7102 a Umeå universitetb Urologi och andrologi4 org
7730 t Cancer Epidemiology, Biomarkers and Preventiond : American Association for Cancer Researchg 22:11, s. 2055-2065q 22:11<2055-2065x 1055-9965x 1538-7755
8564 u http://dx.doi.org/10.1158/1055-9965.EPI-13-0119-Ty FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-85563
8564 8u https://doi.org/10.1158/1055-9965.EPI-13-0119-T
8564 8u https://lup.lub.lu.se/record/4272462

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