Long term outcome after toxic nodular goitre

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Long term outcome after toxic nodular goitre

Sjölin, Gabriel, 1979- (författare): Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Dept. of Surgery, University Hospital, Örebro, Sweden,Örebro Univ Hosp, Fac Med & Hlth, Örebro, Sweden.;Örebro Univ, Dept Surg, S-70185 Örebro, Sweden.;Univ Hosp, S-70185 Örebro, Sweden.

Watt, T. (författare): Department of Medical Endocrinology Rigshospitalet, Copenhagen, Denmark; Internal Medicine Herlev Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark,Rigshosp, Dept Med Endocrinol, Copenhagen, Denmark.;Copenhagen Univ Hosp, Internal Med Herlev Gentofte Hosp, Copenhagen, Denmark.

Byström, Kristina, 1961- (författare): Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Dept. of Medicine, University Hospital, Örebro, Sweden,Univ Hosp, S-70185 Örebro, Sweden.;Örebro Univ, Dept Med, Örebro, Sweden.

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Calissendorff, J. (författare): Karolinska Institute,Karolinska University Hospital

Cramon, P. K. (författare): Department of Medical Endocrinology Rigshospitalet, Copenhagen, Denmark; Internal Medicine Herlev Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark,Rigshosp, Dept Med Endocrinol, Copenhagen, Denmark.;Copenhagen Univ Hosp, Internal Med Herlev Gentofte Hosp, Copenhagen, Denmark.

Nyström, Helena Filipsson, 1966 (författare): University of Gothenburg,Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för medicin,Institute of Medicine,Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden; Dept. of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden; Wallenberg Center for Molecular and Translational Medicine, Göteborg, Sweden,Univ Gothenburg, Sahlgrenska Acad, Inst Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Endocrinol, Gothenburg, Sweden.;Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden.

Hallengren, Bengt (författare): Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital

Holmberg, Mats, 1958 (författare): Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden; ANOVA, Karolinska University Hospital, Stockholm, Sweden,Univ Gothenburg, Sahlgrenska Acad, Inst Med, Gothenburg, Sweden.;Karolinska Univ Hosp, ANOVA, Stockholm, Sweden.

Khamisi, Selwan (författare): Uppsala University,Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala University Hospital

Lantz, Mikael (författare): Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital

Planck, Tereza (författare): Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital

Torring, O. (författare): Karolinska Institute

Wallin, Göran, 1952- (författare): Karolinska Institutet,Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Dept. of Surgery, University Hospital, Örebro, Sweden,Örebro Univ Hosp, Fac Med & Hlth, Örebro, Sweden.;Örebro Univ, Dept Surg, S-70185 Örebro, Sweden.;Univ Hosp, S-70185 Örebro, Sweden.

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2022-11-01
2022
Engelska.
Ingår i: Thyroid Research. - : Springer Science and Business Media LLC. - 1756-6614. ; 15:1

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Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Background: The purpose of treating toxic nodular goitre (TNG) is to reverse hyperthyroidism, prevent recurrent disease, relieve symptoms and preserve thyroid function. Treatment efficacies and long-term outcomes of antithyroid drugs (ATD), radioactive iodine (RAI) or surgery vary in the literature. Symptoms often persist for a long time following euthyroidism, and previous studies have demonstrated long-term cognitive and quality of life (QoL) impairments. We report the outcome of treatment, rate of cure (euthyroidism and hypothyroidism), and QoL in an unselected TNG cohort. Methods: TNG patients (n = 638) de novo diagnosed between 2003-2005 were invited to engage in a 6-10-year follow-up study. 237 patients responded to questionnaires about therapies, demographics, comorbidities, and quality of life (ThyPRO). Patients received ATD, RAI, or surgery according clinical guidelines. Results: The fraction of patients cured with one RAI treatment was 89%, and 93% in patients treated with surgery. The rate of levothyroxine supplementation for RAI and surgery, at the end of the study period, was 58% respectively 64%. Approximately 5% of the patients needed three or more RAI treatments to be cured. The patients had worse thyroid-related QoL scores, in a broad spectrum, than the general population. Conclusion: One advantage of treating TNG with RAI over surgery might be lost due to the seemingly similar incidence of hypothyroidism. The need for up to five treatments is rarely described and indicates that the treatment of TNG can be more complex than expected. This circumstance and the long-term QoL impairments are reminders of the chronic nature of hyperthyroidism from TNG.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Nyckelord

Hyperthyroidism
Toxic nodular goitre
Anti-thyroid drugs
Radioactive
iodine
Thyroidectomy
Long-term follow-up
Recurrence
Cure
Quality of
life
quality-of-life
cardiovascular mortality
antithyroid drugs
follow-up
hyperthyroidism
radioiodine
surgery
hypothyroidism
disease
iodine
Endocrinology & Metabolism
Anti-thyroid drugs
Quality of life
Radioactive iodine

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Av författaren/redakt...: Sjölin, Gabriel, ...; Watt, T.; Byström, Kristin ...; Calissendorff, J ...; Cramon, P. K.; Nyström, Helena ...; visa fler...; Hallengren, Beng ...; Holmberg, Mats, ...; Khamisi, Selwan; Lantz, Mikael; Planck, Tereza; Torring, O.; Wallin, Göran, 1 ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kirurgi

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Endokrinologi oc ...

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Av lärosätet: Göteborgs universitet; Örebro universitet; Uppsala universitet; Lunds universitet; Karolinska Institutet

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