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Physical Activity, Genetic Susceptibility, and the Risk of Latent Autoimmune Diabetes in Adults and Type 2 Diabetes
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- Hjort, Rebecka (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Inst Environm Med, Nobels Väg 13, SE-17177 Stockholm, Sweden
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- Ahlqvist, Emma (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Lund Univ, Clin Res Ctr, Dept Clin Sci Malmö, SE-20502 Malmö, Sweden
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- Andersson, Tomas (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Inst Environm Med, Nobels Väg 13, SE-17177 Stockholm, Sweden; Reg Stockholm, Ctr Occupat & Environm Med, SE-11365 Stockholm, Sweden
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- Alfredsson, Lars (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Inst Environm Med, Nobels Väg 13, SE-17177 Stockholm, Sweden; Reg Stockholm, Ctr Occupat & Environm Med, SE-11365 Stockholm, Sweden
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- Carlsson, Per-Ola (författare)
- Uppsala universitet,Uppsala University,Transplantation och regenerativ medicin
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- Grill, Valdemar (författare)
- Norwegian University of Science and Technology,Norwegian Univ Sci & Technol, NTNU, Dept Clin & Mol Med, NO-7491 Trondheim, Norway
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- Groop, Leif (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki,Lund Univ, Clin Res Ctr, Dept Clin Sci Malmö, SE-20502 Malmö, Sweden; Univ Helsinki, Inst Mol Med Finland FIMM, FI-00014 Helsinki, Finland
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- Martinell, Mats, 1971- (författare)
- Uppsala universitet,Uppsala University,Allmänmedicin och preventivmedicin
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- Sørgjerd, Elin Pettersen (författare)
- Norwegian University of Science and Technology,St. Olav’s University Hospital,Norwegian Univ Sci & Technol, NTNU, Dept Publ Hlth & Nursing, HUNT Res Ctr, NO-7491 Trondheim, Norway; Trondheim Reg & Univ Hosp, Dept Endocrinol, St Olays Hosp, NO-7006 Trondheim, Norway
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- Tuomi, Tiinamaija (författare)
- Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups,University of Helsinki,Institute for Molecular Medicine Finland (FIMM),Helsinki University Central Hospital,Lund Univ, Clin Res Ctr, Dept Clin Sci Malmö, SE-20502 Malmö, Sweden; Univ Helsinki, Inst Mol Med Finland FIMM, FI-00014 Helsinki, Finland; Univ Helsinki, Helsinki Univ Hosp, Abdominal Ctr, Res Program Diabet & Obes,Div Endocrinol, FI-00250 Helsinki, Finland; Folkhälsan Res Ctr, FI-00250 Helsinki, Finland
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- Åsvold, Bjørn Olav (författare)
- Norwegian University of Science and Technology,St. Olav’s University Hospital,Norwegian Univ Sci & Technol, NTNU, Dept Publ Hlth & Nursing, HUNT Res Ctr, NO-7491 Trondheim, Norway; Trondheim Reg & Univ Hosp, Dept Endocrinol, St Olays Hosp, NO-7006 Trondheim, Norway; Norwegian Univ Sci & Technol, Dept Publ Hlth & Nursing, NTNU, KG Jebsen Ctr Genet Epidemiol, NO-7491 Trondheim, Norway
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- Carlsson, Sofia (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Inst Environm Med, Nobels Väg 13, SE-17177 Stockholm, Sweden
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(creator_code:org_t)
- 2020-08-24
- 2020
- Engelska 12 s.
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Ingår i: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 1945-7197 .- 0021-972X. ; 105:11
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Abstract
Ämnesord
Stäng
- PURPOSE: Physical activity (PA) has been linked to a reduced risk of type 2 diabetes by reducing weight and improving insulin sensitivity. We investigated whether PA is associated with a lower incidence of latent autoimmune diabetes in adults (LADA) and whether the association is modified by genotypes of human leukocyte antigen (HLA), transcription factor 7-like 2 (TCF7L2)-rs7903146, or the fat mass and obesity-associated gene, FTO-rs9939609. METHODS: We combined data from a Swedish case-control study and a Norwegian prospective study including 621 incident cases of LADA and 3596 cases of type 2 diabetes. We estimated adjusted pooled relative risks (RRs) and 95% CI of diabetes in relation to high (≥ 30 minutes of moderate activity 3 times/week) self-reported leisure time PA, compared to sedentariness. RESULTS: High PA was associated with a reduced risk of LADA (RR 0.61; CI, 0.43-0.86), which was attenuated after adjustment for body mass index (BMI) (RR 0.90; CI, 0.63-1.29). The reduced risk applied only to noncarriers of HLA-DQB1 and -DRB1 (RR 0.49; CI, 0.33-0.72), TCF7L2 (RR 0.62; CI, 0.45-0.87), and FTO (RR 0.51; CI, 0.32-0.79) risk genotypes. Adjustment for BMI attenuated but did not eliminate these associations. For type 2 diabetes, there was an inverse association with PA (RR 0.49; CI, 0.42-0.56), irrespective of genotype. MAIN CONCLUSIONS: Our findings indicate that high PA is associated with a reduced risk of LADA in individuals without genetic susceptibility.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- gene-environment interaction
- LADA
- latent autoimmune diabetes in adults
- physical activity
- population-based
- type 2 diabetes
- ANDIS
- diabetes
- physical activity
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Hjort, Rebecka
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Ahlqvist, Emma
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Andersson, Tomas
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Alfredsson, Lars
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Carlsson, Per-Ol ...
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Grill, Valdemar
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visa fler...
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Groop, Leif
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Martinell, Mats, ...
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Sørgjerd, Elin P ...
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Tuomi, Tiinamaij ...
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Åsvold, Bjørn Ol ...
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Carlsson, Sofia
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Lunds universitet
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Uppsala universitet
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Karolinska Institutet