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  • Chen, BaoliShandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Shandong Center for Disease Control and Prevention, No. 16992 Jingshi Road, Jinan 250014, Shandong Province, China,Shandong Ctr Dis Control & Prevent, Peoples R China (författare)

Rapid increase in occurrence of carbapenem-resistant Enterobacteriaceae in healthy rural residents in Shandong Province, China, from 2015 to 2017

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • Elsevier,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-107636
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-107636URI
  • https://doi.org/10.1016/j.jgar.2021.11.007DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-203509URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • This study was funded by the National Natural Science Foundation of China [41771499, 81361138021], the Swedish Research Council [D0879801], the Swedish Research Council Formas [2016-00640], ALF Grants, Region Östergötland [LIO-793191 and LIO-899871], Shandong Key Research and Development Plan Project [2017GSF218062] and the Medical and Health Technology Development Program of Shandong Province [2017WS447].
  • Funding Agencies|National Natural Science Foundation of China [41771499, 81361138021]; Swedish Research Council [D0879801]; Swedish Research Council Formas [2016-00640]; Region Ostergotland [LIO-793191, LIO-899871]; Shandong Key Research and Development Plan Project [2017GSF218062]; Medical and Health Technology Development Program of Shandong Province [2017WS447]; ALF Grants
  • OBJECTIVES: The global increase in carbapenem-resistant Enterobacteriaceae (CRE) is a growing health concern. Infections caused by CRE are associated with increased mortality and length of hospital stay, emphasising the health and economic burden posed by these pathogens. Although CRE can inhabit the human gut asymptomatically, colonisation with CRE is associated with an increased risk of CRE infection and mortality. In this study, we investigated the occurrence and characteristics of CRE in faecal samples from healthy persons in 12 villages in Shandong Province, China.METHODS: Screening for CRE in faecal samples was performed by selective cultivation. Minimum inhibitory concentrations (MICs) of meropenem were determined by the agar dilution method. Multilocus sequence typing (MLST) and carbapenemase gene carriage of the isolates were determined by whole-genome sequencing. Genetic relatedness of Escherichia coli isolates was determined by core genome MLST.RESULTS: CRE carriage increased from 2.4% in 2015 to 13.4% in 2017. Most CRE isolates (93.0%) were E. coli and all carried NDM-type carbapenemases. Sequence types (STs) among the E. coli isolates were diverse. The single most common ST was the highly epidemic strain ST167, which was only observed in 2017.CONCLUSION: We report a rapid increase in occurrence of CRE (from 2.4% to 13.4%) among faecal samples collected from healthy rural residents of Shandong Province from 2015 to 2017. Colonisation with CRE is known to increase the risk of CRE infection, and the worrying deterioration of the epidemiological situation in the region reported here indicates a need for further monitoring and possible interventions.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Berglund, BjörnLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Zhejiang Univ, Peoples R China(Swepub:liu)bjobe50 (författare)
  • Wang, ShuangShandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Shandong Center for Disease Control and Prevention, No. 16992 Jingshi Road, Jinan 250014, Shandong Province, China,Shandong Ctr Dis Control & Prevent, Peoples R China (författare)
  • Börjesson, Stefan,1979-Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Natl Vet Inst SVA, Sweden; Publ Hlth Agcy Sweden, Sweden(Swepub:liu)stebo14 (författare)
  • Bi, ZhenqiangShandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Shandong Center for Disease Control and Prevention, No. 16992 Jingshi Road, Jinan 250014, Shandong Province, China,Shandong Ctr Dis Control & Prevent, Peoples R China; Shandong First Med Univ, Peoples R China (författare)
  • Nilsson, Maud,1953-Linköpings universitet,Medicinska fakulteten,Avdelningen för inflammation och infektion(Swepub:liu)mauni03 (författare)
  • Yin, HongLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin(Swepub:liu)honyi87 (författare)
  • Zheng, BeiwenCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated,Zhejiang Univ, Peoples R China (författare)
  • Xiao, YonghongCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated,Zhejiang Univ, Peoples R China (författare)
  • Bi, ZhenwangShandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Shandong Center for Disease Control and Prevention, No. 16992 Jingshi Road, Jinan 250014, Shandong Province, China; Shandong Academy of Clinical Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, China (författare)
  • Nilsson, Lennart,1949-Linköpings universitet,Medicinska fakulteten,Avdelningen för inflammation och infektion(Swepub:liu)lenni43 (författare)
  • Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Shandong Center for Disease Control and Prevention, No. 16992 Jingshi Road, Jinan 250014, Shandong Province, ChinaShandong Ctr Dis Control & Prevent, Peoples R China (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Global Antimicrobial Resistance: Elsevier28, s. 38-422213-71652213-7173

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