SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Chhor Vibol)
 

Sökning: WFRF:(Chhor Vibol) > (2017) > Role of microglia i...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003958naa a2200481 4500
001oai:gup.ub.gu.se/248130
003SwePub
008240528s2017 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/2481302 URI
0247 a https://doi.org/10.1016/j.bbi.2016.11.0012 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Chhor, Vibol4 aut
2451 0a Role of microglia in a mouse model of paediatric traumatic brain injury.
264 1b Elsevier BV,c 2017
520 a The cognitive and behavioural deficits caused by traumatic brain injury (TBI) to the immature brain are more severe and persistent than TBI in the mature brain. Understanding this developmental sensitivity is critical as children under four years of age sustain TBI more frequently than any other age group. Microglia (MG), resident immune cells of the brain that mediate neuroinflammation, are activated following TBI in the immature brain. However, the type and temporal profile of this activation and the consequences of altering it are still largely unknown. In a mouse model of closed head weight drop paediatric brain trauma, we characterized i) the temporal course of total cortical neuroinflammation and the phenotype of ex vivo isolated CD11B-positive microglia/macrophage (MG/MΦ) using a battery of 32 markers, and ii) neuropathological outcome 1 and 5days post-injury. We also assessed the effects of targeting MG/MΦ activation directly, using minocycline a prototypical microglial activation antagonist, on these processes and outcome. TBI induced a moderate increase in both pro- and anti-inflammatory cytokines/chemokines in the ipsilateral hemisphere. Isolated cortical MG/MΦ expressed increased levels of markers of endogenous reparatory/regenerative and immunomodulatory phenotypes compared with shams. Blocking MG/MΦ activation with minocycline at the time of injury and 1 and 2days post-injury had only transient protective effects, reducing ventricular dilatation and cell death 1day post-injury but having no effect on injury severity at 5days. This study demonstrates that, unlike in adults, the role of MG/MΦ in injury mechanisms following TBI in the immature brain may not be negative. An improved understanding of MG/MΦ function in paediatric TBI could support translational efforts to design therapeutic interventions.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng
7001 a Moretti, Raffaella4 aut
7001 a Le Charpentier, Tifenn4 aut
7001 a Sigaut, Stephanie4 aut
7001 a Lebon, Sophie4 aut
7001 a Schwendimann, Leslie4 aut
7001 a Oré, Marie-Virginie4 aut
7001 a Zuiani, Chiara4 aut
7001 a Milan, Valentina4 aut
7001 a Josserand, Julien4 aut
7001 a Vontell, Regina4 aut
7001 a Pansiot, Julien4 aut
7001 a Degos, Vincent4 aut
7001 a Ikonomidou, Chrysanthy4 aut
7001 a Titomanlio, Luigi4 aut
7001 a Hagberg, Henrik,d 1955u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xhaghe
7001 a Gressens, Pierre4 aut
7001 a Fleiss, Bobbi4 aut
7102 a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi4 org
7730 t Brain, behavior, and immunityd : Elsevier BVg 63, s. 197-209q 63<197-209x 1090-2139x 0889-1591
8564 u https://doi.org/10.1016/j.bbi.2016.11.001
8564 8u https://gup.ub.gu.se/publication/248130
8564 8u https://doi.org/10.1016/j.bbi.2016.11.001

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy