Plasma p-tau181 as an outcome and predictor of multidomain intervention effects: a secondary analysis of a randomised, controlled, dementia prevention trial

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Fältnamn	Indikatorer	Metadata
000		09112naa a2201453 4500
001		oai:gup.ub.gu.se/336116
003		SwePub
008		240528s2024 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/3361162 URI
024	7	a https://doi.org/10.1016/S2666-7568(23)00255-62 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Coley, Nicola4 aut
245	1 0	a Plasma p-tau181 as an outcome and predictor of multidomain intervention effects: a secondary analysis of a randomised, controlled, dementia prevention trial
264	1	c 2024
520		a Background: It is unknown whether multidomain interventions, which might preserve late-life cognition, affect Alzheimer's disease pathology. Previous studies measured cerebrospinal fluid and imaging Alzheimer's disease biomarkers in small subsamples of multidomain trial participants. Newly developed assays enable the measurement of blood-based Alzheimer's disease biomarkers in larger samples. We aimed to assess whether plasma tau phosphorylated at threonine 181 (p-tau181) was able to detect or predict 3-year multidomain intervention effects. Methods: This is a secondary analysis of the randomised, controlled, Multidomain Alzheimer Prevention Trial (MAPT) testing a 3-year multidomain intervention, omega-3 fatty acid supplementation, or both versus placebo, in individuals aged 70 years and older in 13 memory centres in France and Monaco. Plasma p-tau181 was measured in stored blood samples in a subsample of 527 participants on an intention-to-treat basis. Changes in cognitive score were calculated as a composite measure using the average of Z scores for the following tests: Mini Mental State Examination orientation items, Free and Cued Selective Reminding Test (sum of free and total recall scores), category fluency, and Digit Symbol Substitution Test. Intervention effects on 3-year change in p-tau181 concentration were estimated by use of a linear mixed model with centre-specific random intercepts. Findings: Recruitment took place between May 30, 2008, and Feb 24, 2011. Median baseline plasma p-tau181 was 8·8 pg/mL (IQR 6·7–11·9) in the total sample, and significantly higher in older individuals, men, APOE ε4 carriers, and participants with renal dysfunction or a positive PET amyloid scan. During 3-year follow-up, individuals with raised baseline p-tau181 underwent greater cognitive decline (eg, mean difference in 3-year change on the composite cognitive score between control group participants with normal and abnormal baseline levels of p-tau was −0·34 [effect size −0·52; 95% CI −0·61 to 0·07] in the fully adjusted model using a 12·4 pg/mL cutoff for abnormal baseline p-tau181), but there were no intervention effects on change in p-tau181 either in this subgroup or the total population, and no effect on cognitive change in individuals with raised baseline p-tau181 (eg, in the fully adjusted model using the 12·4 pg/mL cutoff for p-tau181 abnormality, the mean difference [95% CI] in this subgroup in 3-year decline on the composite cognitive score between the control group and the multidomain + omega-3 group, the omega-3 group, and the multidomain intervention group, was, respectively: 0·13 [−0·21 to 0·47], 0·03 [−0·30 to 0·36], and 0·10 [−0·26 to 0·46]). Surprisingly, individuals with raised baseline p-tau181 showed a decrease in p-tau181 during follow-up (eg, unadjusted mean [95% CI] 3-year change was −3·01 pg/mL (−4·45 to −1·56) in control group subjects with abnormal baseline p-tau181 [using the 12·4 pg/mL abnormal p-tau cutoff]). Interpretation: Our results support the utility of p-tau181 as a prognostic biomarker, but it did not predict or detect intervention effects in this study. Further investigation of its usefulness as a prevention trial outcome measure is required.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
700	1	a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe
700	1	a Cantet, Christelle4 aut
700	1	a Guyonnet, Sophie4 aut
700	1	a Ashton, Nicholas J.u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xashtn
700	1	a Vellas, Bruno4 aut
700	1	a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka
700	1	a Andrieu, Sandrine4 aut
700	1	a Carrié, Isabelle4 aut
700	1	a Brigitte, Lauréane4 aut
700	1	a Faisant, Catherine4 aut
700	1	a Lala, Françoise4 aut
700	1	a Delrieu, Julien4 aut
700	1	a Villars, Hélène4 aut
700	1	a Combrouze, Emeline4 aut
700	1	a Badufle, Carole4 aut
700	1	a Zueras, Audrey4 aut
700	1	a Morin, Christophe4 aut
700	1	a Abellan Van Kan, Gabor4 aut
700	1	a Dupuy, Charlotte4 aut
700	1	a Rolland, Yves4 aut
700	1	a Caillaud, Céline4 aut
700	1	a Ousset, Pierre Jean4 aut
700	1	a Willis, Sherry4 aut
700	1	a Belleville, Sylvie4 aut
700	1	a Gilbert, Brigitte4 aut
700	1	a Fontaine, Francine4 aut
700	1	a Dartigues, Jean François4 aut
700	1	a Marcet, Isabelle4 aut
700	1	a Delva, Fleur4 aut
700	1	a Foubert, Alexandra4 aut
700	1	a Cerda, Sandrine4 aut
700	1	a Cuffi, Marie Noëlle4 aut
700	1	a Costes, Corinne4 aut
700	1	a Rouaud, Olivier4 aut
700	1	a Manckoundia, Patrick4 aut
700	1	a Quipourt, Valérie4 aut
700	1	a Marilier, Sophie4 aut
700	1	a Franon, Evelyne4 aut
700	1	a Bories, Lawrence4 aut
700	1	a Pader, Marie Laure4 aut
700	1	a Basset, Marie France4 aut
700	1	a Lapoujade, Bruno4 aut
700	1	a Faure, Valérie4 aut
700	1	a Li Yung Tong, Michael4 aut
700	1	a Malick-Loiseau, Christine4 aut
700	1	a Cazaban-Campistron, Evelyne4 aut
700	1	a Desclaux, Françoise4 aut
700	1	a Blatge, Colette4 aut
700	1	a Dantoine, Thierry4 aut
700	1	a Laubarie-Mouret, Cécile4 aut
700	1	a Saulnier, Isabelle4 aut
700	1	a Clément, Jean Pierre4 aut
700	1	a Picat, Marie Agnès4 aut
700	1	a Bernard-Bourzeix, Laurence4 aut
700	1	a Willebois, Stéphanie4 aut
700	1	a Désormais, Iléana4 aut
700	1	a Cardinaud, Noëlle4 aut
700	1	a Bonnefoy, Marc4 aut
700	1	a Livet, Pierre4 aut
700	1	a Rebaudet, Pascale4 aut
700	1	a Gédéon, Claire4 aut
700	1	a Burdet, Catherine4 aut
700	1	a Terracol, Flavien4 aut
700	1	a Pesce, Alain4 aut
700	1	a Roth, Stéphanie4 aut
700	1	a Chaillou, Sylvie4 aut
700	1	a Louchart, Sandrine4 aut
700	1	a Sudres, Kristel4 aut
700	1	a Lebrun, Nicolas4 aut
700	1	a Barro-Belaygues, Nadège4 aut
700	1	a Touchon, Jacques4 aut
700	1	a Bennys, Karim4 aut
700	1	a Gabelle, Audrey4 aut
700	1	a Romano, Aurélia4 aut
700	1	a Touati, Lynda4 aut
700	1	a Marelli, Cécilia4 aut
700	1	a Pays, Cécile4 aut
700	1	a Robert, Philippe4 aut
700	1	a Le Duff, Franck4 aut
700	1	a Gervais, Claire4 aut
700	1	a Gonfrier, Sébastien4 aut
700	1	a Gasnier, Yannick4 aut
700	1	a Bordes, Serge4 aut
700	1	a Begorre, Danièle4 aut
700	1	a Carpuat, Christian4 aut
700	1	a Khales, Khaled4 aut
700	1	a Lefebvre, Jean François4 aut
700	1	a Misbah El Idrissi, Samira4 aut
700	1	a Skolil, Pierre4 aut
700	1	a Salles, Jean Pierre4 aut
700	1	a Dufouil, Carole4 aut
700	1	a Lehéricy, Stéphane4 aut
700	1	a Chupin, Marie4 aut
700	1	a Mangin, Jean François4 aut
700	1	a Bouhayia, Ali4 aut
700	1	a Allard, Michèle4 aut
700	1	a Ricolfi, Frédéric4 aut
700	1	a Dubois, Dominique4 aut
700	1	a Bonceour Martel, Marie Paule4 aut
710	2	a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org
773	0	t The Lancet Healthy Longevityg 5:2q 5:2x 2666-7568
856	4 8	u https://gup.ub.gu.se/publication/336116
856	4 8	u https://doi.org/10.1016/S2666-7568(23)00255-6

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Av författaren/redakt...: Coley, Nicola; Zetterberg, Henr ...; Cantet, Christel ...; Guyonnet, Sophie; Ashton, Nicholas ...; Vellas, Bruno; visa fler...; Blennow, Kaj, 19 ...; Andrieu, Sandrin ...; Carrié, Isabelle; Brigitte, Lauréa ...; Faisant, Catheri ...; Lala, Françoise; Delrieu, Julien; Villars, Hélène; Combrouze, Emeli ...; Badufle, Carole; Zueras, Audrey; Morin, Christoph ...; Abellan Van Kan, ...; Dupuy, Charlotte; Rolland, Yves; Caillaud, Céline; Ousset, Pierre J ...; Willis, Sherry; Belleville, Sylv ...; Gilbert, Brigitt ...; Fontaine, Franci ...; Dartigues, Jean ...; Marcet, Isabelle; Delva, Fleur; Foubert, Alexand ...; Cerda, Sandrine; Cuffi, Marie Noë ...; Costes, Corinne; Rouaud, Olivier; Manckoundia, Pat ...; Quipourt, Valéri ...; Marilier, Sophie; Franon, Evelyne; Bories, Lawrence; Pader, Marie Lau ...; Basset, Marie Fr ...; Lapoujade, Bruno; Faure, Valérie; Li Yung Tong, Mi ...; Malick-Loiseau, ...; Cazaban-Campistr ...; Desclaux, Franço ...; Blatge, Colette; Dantoine, Thierr ...; Laubarie-Mouret, ...; Saulnier, Isabel ...; Clément, Jean Pi ...; Picat, Marie Agn ...; Bernard-Bourzeix ...; Willebois, Stéph ...; Désormais, Iléan ...; Cardinaud, Noëll ...; Bonnefoy, Marc; Livet, Pierre; Rebaudet, Pascal ...; Gédéon, Claire; Burdet, Catherin ...; Terracol, Flavie ...; Pesce, Alain; Roth, Stéphanie; Chaillou, Sylvie; Louchart, Sandri ...; Sudres, Kristel; Lebrun, Nicolas; Barro-Belaygues, ...; Touchon, Jacques; Bennys, Karim; Gabelle, Audrey; Romano, Aurélia; Touati, Lynda; Marelli, Cécilia; Pays, Cécile; Robert, Philippe; Le Duff, Franck; Gervais, Claire; Gonfrier, Sébast ...; Gasnier, Yannick; Bordes, Serge; Begorre, Danièle; Carpuat, Christi ...; Khales, Khaled; Lefebvre, Jean F ...; Misbah El Idriss ...; Skolil, Pierre; Salles, Jean Pie ...; Dufouil, Carole; Lehéricy, Stépha ...; Chupin, Marie; Mangin, Jean Fra ...; Bouhayia, Ali; Allard, Michèle; Ricolfi, Frédéri ...; Dubois, Dominiqu ...; Bonceour Martel, ...; visa färre...

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