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Association between...
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Cooper, Lauren B.Karolinska Institutet,Inova Heart and Vasc Inst, VA 22042 USA; Duke Univ, NC 27706 USA
(författare)
Association between potassium level and outcomes in heart failure with reduced ejection fraction: a cohort study from the Swedish Heart Failure Registry
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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2020-02-20
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WILEY,2020
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-164255
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-164255URI
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https://doi.org/10.1002/ejhf.1757DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:143015166URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies|Swedish Federal Government through the Swedish Association of Local Authorities and Regions; Swedish Research CouncilSwedish Research Council [2013-23897-104604-23, 523-2014-2336, 2019-01059]; Swedish Heart Lung FoundationSwedish Heart-Lung Foundation [20120321, 20150557]; Stockholm County CouncilStockholm County Council [20110120, 20140220]
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Aims Hyperkalaemia and hypokalaemia are common in heart failure and associated with worse outcomes. However, the optimal potassium range is unknown. We sought to determine the optimal range of potassium in patients with heart failure and reduced ejection fraction (amp;lt; 40%) by exploring the relationship between baseline potassium level and short- and long-term outcomes using the Swedish Heart Failure Registry from 1 January 2006 to 31 December 2012. Methods and results We assessed the association between baseline potassium level and all-cause mortality at 30 days, 12 months, and maximal follow-up, in uni- and multivariable stratified and restricted cubic spline Cox regressions. Of 13 015 patients, 93.3% had potassium 3.5-5.0 mmol/L, 3.7% had potassium amp;lt;3.5 mmol/L, and 3.0% had potassium amp;gt;5.0 mmol/L. Potassium 5.0 mmol/L were more common with lower estimated glomerular filtration rate and heart failure of longer duration and greater severity. The potassium level associated with the lowest hazard risk for mortality at 30 days, 12 months, and maximal follow-up was 4.2 mmol/L, and there was a steep increase in risk with both higher and lower potassium levels. In adjusted strata analyses, lower potassium was independently associated with all-cause mortality at 12 months and maximal follow-up, while higher potassium levels only increased risk at 30 days. Conclusion In this nationwide registry, the relationship between potassium and mortality was U-shaped, with an optimal potassium value of 4.2 mmol/L. After multivariable adjustment, hypokalaemia was associated with increased long-term mortality but hyperkalaemia was associated with increased short-term mortality.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Benson, LinaKarolinska Inst, Sweden
(författare)
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Mentz, Robert J.Duke Univ, NC 27706 USA
(författare)
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Savarese, GianluigiKarolinska Institutet,Karolinska Inst, Sweden
(författare)
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DeVore, Adam D.Duke Univ, NC 27706 USA
(författare)
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Carrero, Juan-JesusKarolinska Institutet,Karolinska Inst, Sweden
(författare)
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Dahlström, Ulf,1946-Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)ulfda85
(författare)
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Anker, Stefan D.Berlin Brandenburg Ctr Regenerat Therapies, Germany; Charite, Germany
(författare)
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Lainscak, MitjaGen Hosp Murska Sobota, Slovenia; Univ Ljubljana, Slovenia
(författare)
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Hernandez, Adrian F.Duke Univ, NC 27706 USA
(författare)
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Pitt, BertramUniv Michigan, MI USA
(författare)
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Lund, Lars H.Karolinska Institutet,Karolinska Inst, Sweden
(författare)
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Karolinska InstitutetInova Heart and Vasc Inst, VA 22042 USA; Duke Univ, NC 27706 USA
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Journal of Heart Failure: WILEY22:8, s. 1390-13981388-98421879-0844
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Cooper, Lauren B ...
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Benson, Lina
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Mentz, Robert J.
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Savarese, Gianlu ...
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DeVore, Adam D.
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Carrero, Juan-Je ...
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Dahlström, Ulf, ...
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Anker, Stefan D.
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Lainscak, Mitja
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Hernandez, Adria ...
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Pitt, Bertram
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Lund, Lars H.
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