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Pancreatic Cancer h...
Pancreatic Cancer hENT1 Expression and Survival From Gemcitabine in Patients From the ESPAC-3 Trial
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Greenhalf, William (author)
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Ghaneh, Paula (author)
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Neoptolemos, John P. (author)
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Palmer, Daniel H. (author)
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Cox, Trevor F. (author)
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Lamb, Richard F. (author)
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Garner, Elizabeth (author)
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Campbell, Fiona (author)
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Mackey, John R. (author)
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Costello, Eithne (author)
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Moore, Malcolm J. (author)
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Valle, Juan W. (author)
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McDonald, Alexander C. (author)
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Carter, Ross (author)
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Tebbutt, Niall C. (author)
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Goldstein, David (author)
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Shannon, Jennifer (author)
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Dervenis, Christos (author)
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- Glimelius, Bengt (author)
- Uppsala universitet,Enheten för onkologi
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Deakin, Mark (author)
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Charnley, Richard M. (author)
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Lacaine, Francois (author)
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Scarfe, Andrew G. (author)
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Middleton, Mark R. (author)
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Anthoney, Alan (author)
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Halloran, Christopher M. (author)
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Mayerle, Julia (author)
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Olah, Attila (author)
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Jackson, Richard (author)
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Rawcliffe, Charlotte L. (author)
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Scarpa, Aldo (author)
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Bassi, Claudio (author)
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Buechler, Markus W. (author)
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(creator_code:org_t)
- 2013-12-03
- 2014
- English.
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In: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 106:1, s. djt347-
- Related links:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background Human equilibrative nucleoside transporter 1 (hENT1) levels in pancreatic adenocarcinoma may predict survival in patients who receive adjuvant gemcitabine after resection. Methods Microarrays from 434 patients randomized to chemotherapy in the ESPAC-3 trial (plus controls from ESPAC-1/3) were stained with the 10D7G2 anti-hENT1 antibody. Patients were classified as having high hENT1 expression if the mean H score for their cores was above the overall median H score (48). High and low hENT1-expressing groups were compared using Kaplan-Meier curves, log-rank tests, and Cox proportional hazards models. All statistical tests were two-sided. Results Three hundred eighty patients (87.6%) and 1808 cores were suitable and included in the final analysis. Median overall survival for gemcitabine-treated patients (n = 176) was 23.4 (95% confidence interval [CI] = 18.3 to 26.0) months vs 23.5 (95% CI = 19.8 to 27.3) months for 176 patients treated with 5-fluorouracil/folinic acid (months vs 23.5 (95% CI = 19.8 to 27.3) months for 176 patients treated with 5-fluorouracil/folinic acid (chi(2)(1)=0.24; P = .62). Median survival for patients treated with gemcitabine was 17.1 (95% CI = 14.3 to 23.8) months for those with low hENT1 expression vs 26.2 (95% CI = 21.2 to 31.4) months for those with high hENT1 expression (chi(2)(1)=9.87; P = .002). For the 5-fluorouracil group, median survival was 25.6 (95% CI = 20.1 to 27.9) and 21.9 (95% CI = 16.0 to 28.3) months for those with low and high hENT1 expression, respectively (chi(2)(1) = 0.83; P = .36). hENT1 levels were not predictive of survival for the 28 patients of the observation group (chi(2)(1) = 0.37; P = .54). Multivariable analysis confirmed hENT1 expression as a predictive marker in gemcitabine-treated (Wald chi(2)(1) = 9.16; P = .003) but not 5-fluorouracil-treated (Wald chi(2)(1) = 1.22; P = .27) patients. Conclusions Subject to prospective validation, gemcitabine should not be used for patients with low tumor hENT1 expression.
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Greenhalf, Willi ...
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Ghaneh, Paula
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Neoptolemos, Joh ...
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Palmer, Daniel H ...
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Cox, Trevor F.
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Lamb, Richard F.
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show more...
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Garner, Elizabet ...
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Campbell, Fiona
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Mackey, John R.
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Costello, Eithne
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Moore, Malcolm J ...
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Valle, Juan W.
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McDonald, Alexan ...
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Carter, Ross
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Tebbutt, Niall C ...
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Goldstein, David
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Shannon, Jennife ...
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Dervenis, Christ ...
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Glimelius, Bengt
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Deakin, Mark
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Charnley, Richar ...
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Lacaine, Francoi ...
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Scarfe, Andrew G ...
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Middleton, Mark ...
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Anthoney, Alan
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Halloran, Christ ...
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Mayerle, Julia
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Olah, Attila
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Jackson, Richard
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Rawcliffe, Charl ...
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Scarpa, Aldo
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Bassi, Claudio
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Buechler, Markus ...
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show less...
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Journal of the N ...
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Uppsala University