Sökning: WFRF:(Crews Fulton) > Liu Yun > The Cortical Neuroi...
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000 | 12185naa a2200925 4500 | |
001 | oai:DiVA.org:uu-393754 | |
003 | SwePub | |
008 | 191018s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3937542 URI |
024 | 7 | a https://doi.org/10.1093/cercor/bhy3412 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Mueller, Christian P.u Friedrich Alexander Univ Erlangen Nuremberg, Univ Clin, Dept Psychiat & Psychotherapy, Sect Addict Med, Schwabachanlage 6, D-91054 Erlangen, Germany4 aut |
245 | 1 0 | a The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking :b A Translational Study |
264 | c 2019-02-04 | |
264 | 1 | b OXFORD UNIV PRESS INC,c 2019 |
338 | a electronic2 rdacarrier | |
520 | a Alcohol abuse is a major public health problem worldwide. Understanding the molecular mechanisms that control regular drinking may help to reduce hazards of alcohol consumption. While immunological mechanisms have been related to alcohol drinking, most studies reported changes in immune function that are secondary to alcohol use. In this report, we analyse how the gene "TRAF family member-associated NF-kappa B activator" (TANK) affects alcohol drinking behavior. Based on our recent discovery in a large GWAS dataset that suggested an association of TANK, SNP rs197273, with alcohol drinking, we report that SNP rs197273 in TANK is associated both with gene expression (P = 1.16 x 10(-19)) and regional methylation (P = 5.90 x 10(-25)). A tank knock out mouse model suggests a role of TANK in alcohol drinking, anxiety-related behavior, as well as alcohol exposure induced activation of insular cortex NF-kappa B. Functional and structural neuroimaging studies among up to 1896 adolescents reveal that TANK is involved in the control of brain activity in areas of aversive interoceptive processing, including the insular cortex, but not in areas related to reinforcement, reward processing or impulsiveness. Our findings suggest that the cortical neuroimmune regulator TANK is associated with enhanced aversive emotional processing that better protects from the establishment of alcohol drinking behavior. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
653 | a alcohol | |
653 | a anxiety | |
653 | a drinking | |
653 | a insular cortex | |
653 | a NF-kappa B | |
653 | a TANK | |
700 | 1 | a Chu, Congyingu Kings Coll London, Inst Psychiat Psychol & Neurosci, Ctr Populat Neurosci & Stratified Med PONS, De Crespigny Pk, London SE5 8AF, England;Kings Coll London, Inst Psychiat Psychol & Neurosci, MRC SGDP Ctr, De Crespigny Pk, London SE5 8AF, England4 aut |
700 | 1 | a Qin, Liyau Univ N Carolina, Sch Med, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA4 aut |
700 | 1 | a Liu, Chunyuu Framingham Heart Dis Epidemiol Study, 73 Mt Wayte Ave, Framingham, MA 01702 USA;NHLBI, Populat Sci Branch, Div Intramural Res, Bethesda, MD 20824 USA;Boston Univ, Sch Publ Hlth, 715 Albany St, Boston, MA 02118 USA4 aut |
700 | 1 | a Xu, Bingu Kings Coll London, Inst Psychiat Psychol & Neurosci, Ctr Populat Neurosci & Stratified Med PONS, De Crespigny Pk, London SE5 8AF, England;Kings Coll London, Inst Psychiat Psychol & Neurosci, MRC SGDP Ctr, De Crespigny Pk, London SE5 8AF, England4 aut |
700 | 1 | a Gao, Heu Imperial Coll London, Sch Publ Hlth, MRC PHE Ctr Environm & Hlth, Dept Epidemiol & Biostat, London W2 1PG, England4 aut |
700 | 1 | a Ruggeri, Barbarau Kings Coll London, Inst Psychiat Psychol & Neurosci, Ctr Populat Neurosci & Stratified Med PONS, De Crespigny Pk, London SE5 8AF, England;Kings Coll London, Inst Psychiat Psychol & Neurosci, MRC SGDP Ctr, De Crespigny Pk, London SE5 8AF, England4 aut |
700 | 1 | a Hieber, Saskiau Friedrich Alexander Univ Erlangen Nuremberg, Univ Clin, Dept Psychiat & Psychotherapy, Sect Addict Med, Schwabachanlage 6, D-91054 Erlangen, Germany4 aut |
700 | 1 | a Schneider, Juliau Friedrich Alexander Univ Erlangen Nuremberg, Inst Biochem & Mol Med, Fahrstr 17, D-91054 Erlangen, Germany4 aut |
700 | 1 | a Jia, Tianyeu Kings Coll London, Inst Psychiat Psychol & Neurosci, Ctr Populat Neurosci & Stratified Med PONS, De Crespigny Pk, London SE5 8AF, England;Kings Coll London, Inst Psychiat Psychol & Neurosci, MRC SGDP Ctr, De Crespigny Pk, London SE5 8AF, England4 aut |
700 | 1 | a Tay, Nicoleu Kings Coll London, Inst Psychiat Psychol & Neurosci, Ctr Populat Neurosci & Stratified Med PONS, De Crespigny Pk, London SE5 8AF, England;Kings Coll London, Inst Psychiat Psychol & Neurosci, MRC SGDP Ctr, De Crespigny Pk, London SE5 8AF, England4 aut |
700 | 1 | a Akira, Shizuou Osaka Univ, Microbial Dis Res Inst, World Premier Int Immunol Frontiern Res Ctr, Lab Host Def, 1-1 Yamadaoka, Suita, Osaka 5650871, Japan4 aut |
700 | 1 | a Satoh, Takashiu Osaka Univ, Microbial Dis Res Inst, World Premier Int Immunol Frontiern Res Ctr, Lab Host Def, 1-1 Yamadaoka, Suita, Osaka 5650871, Japan4 aut |
700 | 1 | a Banaschewski, Tobiasu Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat & Psychotherapy, J5, D-68159 Mannheim, Germany4 aut |
700 | 1 | a Bokde, Arun L. W.u Trinity Coll Dublin, Sch Med, Discipline Psychiat, Jamess St, Dublin 8, Ireland;Trinity Coll Dublin, Trin Coll Inst Neurosci, Jamess St, Dublin 8, Ireland4 aut |
700 | 1 | a Bromberg, Uliu Univ Med Ctr Hamburg Eppendorf, House W34,3 OG,Martinistr 52, D-20246 Hamburg, Germany4 aut |
700 | 1 | a Buechel, Christianu Univ Med Ctr Hamburg Eppendorf, House W34,3 OG,Martinistr 52, D-20246 Hamburg, Germany4 aut |
700 | 1 | a Quinlan, Erin Burkeu Kings Coll London, Inst Psychiat Psychol & Neurosci, Ctr Populat Neurosci & Stratified Med PONS, De Crespigny Pk, London SE5 8AF, England;Kings Coll London, Inst Psychiat Psychol & Neurosci, MRC SGDP Ctr, De Crespigny Pk, London SE5 8AF, England4 aut |
700 | 1 | a Flor, Hertau Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Cognit & Clin Neurosci, J5, D-68159 Mannheim, Germany;Univ Mannheim, Sch Social Sci, Dept Psychol, D-68131 Mannheim, Germany4 aut |
700 | 1 | a Frouin, Vincentu Univ Paris Saclay, CEA, NeuroSpin, F-91191 Gif Sur Yvette, France4 aut |
700 | 1 | a Garavan, Hughu Univ Vermont, Dept Psychiat, Burlington, VT 05405 USA;Univ Vermont, Dept Psychol, Burlington, VT 05405 USA4 aut |
700 | 1 | a Gowland, Pennyu Univ Nottingham, Sch Phys & Astron, Sir Peter Mansfield Imaging Ctr, Univ Pk, Nottingham NG7 2QX, England4 aut |
700 | 1 | a Heinz, Andreasu Charite Univ Med Berlin, Campus Charite Mitte, Dept Psychiat & Psychotherapy, Charitepl 1, D-10117 Berlin, Germany4 aut |
700 | 1 | a Ittermann, Berndu PTB, Braunschweig, Germany;PTB, Abbestr 2-12, D-10587 Berlin, Germany4 aut |
700 | 1 | a Martinot, Jean-Lucu Univ Paris Saclay, Univ Paris Sud, INSERM, Unit 1000,Neuroimaging & Psychiat,DIGITEO Labs, Rue Noetzlin, F-91190 Gif Sur Yvette, France4 aut |
700 | 1 | a Martinot, Marie-Laure Paillereu Univ Paris Saclay, Univ Paris Sud, INSERM, Unit 1000,Neuroimaging & Psychiat, Gif Sur Yvette, France;Hop La Pitie Salpetriere, AP HP, Dept Child & Adolescent Psychiat, 47-83 Blvd Hop, F-75013 Paris, France4 aut |
700 | 1 | a Artiges, Ericu Univ Paris Saclay, Univ Paris Sud, INSERM, Unit 1000,Neuroimaging & Psychiat,DIGITEO Labs, Rue Noetzlin, F-91190 Gif Sur Yvette, France;Orsay Hosp, Psychiat Dept 91G16, Orsay, France4 aut |
700 | 1 | a Lemaitre, Herveu Univ Paris Sud, Sch Med, INSERM, Unit 1000,Neuroimaging & Psychiat, Gif Sur Yvette, France4 aut |
700 | 1 | a Nees, Fraukeu Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat & Psychotherapy, J5, D-68159 Mannheim, Germany;Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Cognit & Clin Neurosci, J5, D-68159 Mannheim, Germany4 aut |
700 | 1 | a Orfanos, Dimitri Papadopoulosu Univ Paris Saclay, CEA, NeuroSpin, F-91191 Gif Sur Yvette, France4 aut |
700 | 1 | a Paus, Tomasu Univ Toronto, Rotman Res Inst, 3560 Bathurst St, Toronto, ON M6A 2E1, Canada;Univ Toronto, Dept Psychol, 3560 Bathurst St, Toronto, ON M6A 2E1, Canada;Univ Toronto, Dept Psychiat, 3560 Bathurst St, Toronto, ON M6A 2E1, Canada4 aut |
700 | 1 | a Poustka, Luiseu Univ Med Ctr Gottingen, Dept Child & Adolescent Psychiat & Psychotherapy, von Siebold Str 5, D-37075 Gottingen, Germany;Med Univ Vienna, Clin Child & Adolescent Psychiat, Wahringer Gurtel 18-20, A-1090 Vienna, Austria4 aut |
700 | 1 | a Millenet, Sabinau Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat & Psychotherapy, J5, D-68159 Mannheim, Germany4 aut |
700 | 1 | a Froehner, Juliane H.u Tech Univ Dresden, Dept Psychiat, Chemnitzer Str 46a, D-01187 Dresden, Germany;Tech Univ Dresden, Neuroimaging Ctr, Chemnitzer Str 46a, D-01187 Dresden, Germany4 aut |
700 | 1 | a Smolka, Michael N.u Tech Univ Dresden, Dept Psychiat, Chemnitzer Str 46a, D-01187 Dresden, Germany;Tech Univ Dresden, Neuroimaging Ctr, Chemnitzer Str 46a, D-01187 Dresden, Germany4 aut |
700 | 1 | a Walter, Henriku Charite Univ Med Berlin, Campus Charite Mitte, Dept Psychiat & Psychotherapy, Charitepl 1, D-10117 Berlin, Germany4 aut |
700 | 1 | a Whelan, Robertu Aras Phiarsaigh Trinity Coll Dublin, Sch Psychol, Dublin 2, Ireland;Aras Phiarsaigh Trinity Coll Dublin, Global Brain Hlth Inst, Dublin 2, Ireland4 aut |
700 | 1 | a Bakalkin, Georgyu Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)gueba200 |
700 | 1 | a Liu, Yunu Minist Educ, Key Lab Metab & Mol Med, Shanghai, Peoples R China;Fudan Univ, Shanghai Med Coll, Dept Biochem & Mol Biol, Shanghai, Peoples R China4 aut |
700 | 1 | a Desrivieres, Sylvaneu Kings Coll London, Inst Psychiat Psychol & Neurosci, Ctr Populat Neurosci & Stratified Med PONS, De Crespigny Pk, London SE5 8AF, England;Kings Coll London, Inst Psychiat Psychol & Neurosci, MRC SGDP Ctr, De Crespigny Pk, London SE5 8AF, England4 aut |
700 | 1 | a Elliott, Paulu Imperial Coll London, Sch Publ Hlth, MRC PHE Ctr Environm & Hlth, Dept Epidemiol & Biostat, London W2 1PG, England4 aut |
700 | 1 | a Eulenburg, Volkeru Friedrich Alexander Univ Erlangen Nuremberg, Inst Biochem & Mol Med, Fahrstr 17, D-91054 Erlangen, Germany;Univ Leipzig, Dept Anaesthesiol & Intens Care Med, Liebigstr 20, D-04103 Leipzig, Germany4 aut |
700 | 1 | a Levy, Danielu Framingham Heart Dis Epidemiol Study, 73 Mt Wayte Ave, Framingham, MA 01702 USA;NHLBI, Populat Sci Branch, Div Intramural Res, Bethesda, MD 20824 USA4 aut |
700 | 1 | a Crews, Fultonu Univ N Carolina, Sch Med, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA4 aut |
700 | 1 | a Schumann, Gunteru Kings Coll London, Inst Psychiat Psychol & Neurosci, Ctr Populat Neurosci & Stratified Med PONS, De Crespigny Pk, London SE5 8AF, England;Kings Coll London, Inst Psychiat Psychol & Neurosci, MRC SGDP Ctr, De Crespigny Pk, London SE5 8AF, England4 aut |
710 | 2 | a Friedrich Alexander Univ Erlangen Nuremberg, Univ Clin, Dept Psychiat & Psychotherapy, Sect Addict Med, Schwabachanlage 6, D-91054 Erlangen, Germanyb Kings Coll London, Inst Psychiat Psychol & Neurosci, Ctr Populat Neurosci & Stratified Med PONS, De Crespigny Pk, London SE5 8AF, England;Kings Coll London, Inst Psychiat Psychol & Neurosci, MRC SGDP Ctr, De Crespigny Pk, London SE5 8AF, England4 org |
773 | 0 | t Cerebral Cortexd : OXFORD UNIV PRESS INCg 29:4, s. 1736-1751q 29:4<1736-1751x 1047-3211x 1460-2199 |
856 | 4 | u https://doi.org/10.1093/cercor/bhy341y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1362378/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://academic.oup.com/cercor/article-pdf/29/4/1736/28213075/bhy341.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-393754 |
856 | 4 8 | u https://doi.org/10.1093/cercor/bhy341 |
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