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Rare genetic varian...
Rare genetic variants explain missing heritability in smoking.
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- Jang, Seon-Kyeong (author)
- University of Minnesota
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Evans, Luke (author)
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Fialkowski, Allison (author)
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show more...
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Arnett, Donna K (author)
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Ashley-Koch, Allison E (author)
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Barnes, Kathleen C (author)
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Becker, Diane M (author)
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Bis, Joshua C (author)
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Blangero, John (author)
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Bleecker, Eugene R (author)
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Boorgula, Meher Preethi (author)
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Bowden, Donald W (author)
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Brody, Jennifer A (author)
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Cade, Brian E (author)
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Jenkins, Brenda W Campbell (author)
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Carson, April P (author)
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Chavan, Sameer (author)
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Cupples, L Adrienne (author)
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Custer, Brian (author)
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Damrauer, Scott M (author)
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David, Sean P (author)
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de Andrade, Mariza (author)
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Dinardo, Carla L (author)
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Fingerlin, Tasha E (author)
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Fornage, Myriam (author)
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Freedman, Barry I (author)
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Garrett, Melanie E (author)
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Gharib, Sina A (author)
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Glahn, David C (author)
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Haessler, Jeffrey (author)
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Heckbert, Susan R (author)
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Hokanson, John E (author)
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Hou, Lifang (author)
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Hwang, Shih-Jen (author)
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Hyman, Matthew C (author)
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Judy, Renae (author)
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Justice, Anne E (author)
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Kaplan, Robert C (author)
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Kardia, Sharon L R (author)
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Kelly, Shannon (author)
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Kim, Wonji (author)
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Kooperberg, Charles (author)
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Levy, Daniel (author)
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Lloyd-Jones, Donald M (author)
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Loos, Ruth J F (author)
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Manichaikul, Ani W (author)
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Gladwin, Mark T (author)
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Martin, Lisa Warsinger (author)
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Nouraie, Mehdi (author)
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- Melander, O. (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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Meyers, Deborah A (author)
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Montgomery, Courtney G (author)
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North, Kari E (author)
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Oelsner, Elizabeth C (author)
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Palmer, Nicholette D (author)
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Payton, Marinelle (author)
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Peljto, Anna L (author)
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Peyser, Patricia A (author)
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Preuss, Michael (author)
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Psaty, Bruce M (author)
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Qiao, Dandi (author)
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Rader, Daniel J (author)
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Rafaels, Nicholas (author)
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Redline, Susan (author)
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Reed, Robert M (author)
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Reiner, Alexander P (author)
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Rich, Stephen S (author)
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Rotter, Jerome I (author)
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Schwartz, David A (author)
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Shadyab, Aladdin H (author)
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Silverman, Edwin K (author)
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Smith, Nicholas L (author)
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- Smith, J. Gustav, 1982 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Smith, Albert V (author)
- University of Minnesota
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Smith, Jennifer A (author)
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Tang, Weihong (author)
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Taylor, Kent D (author)
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Telen, Marilyn J (author)
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Vasan, Ramachandran S (author)
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Gordeuk, Victor R (author)
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Wang, Zhe (author)
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Wiggins, Kerri L (author)
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Yanek, Lisa R (author)
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Yang, Ivana V (author)
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Young, Kendra A (author)
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Young, Kristin L (author)
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Zhang, Yingze (author)
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Liu, Dajiang J (author)
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Keller, Matthew C (author)
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Vrieze, Scott (author)
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(creator_code:org_t)
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et al
- 2022-08-04
- 2022
- English.
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In: Nature human behaviour. - : Springer Science and Business Media LLC. - 2397-3374. ; 6:11, s. 1577-1586
- Related links:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- Common genetic variants explain less variation in complex phenotypes than inferred from family-based studies, and there is a debate on the source of this 'missing heritability'. We investigated the contribution of rare genetic variants to tobacco use with whole-genome sequences from up to 26,257 unrelated individuals of European ancestries and 11,743 individuals of African ancestries. Across four smoking traits, single-nucleotide-polymorphism-based heritability ([Formula: see text]) was estimated from 0.13 to 0.28 (s.e., 0.10-0.13) in European ancestries, with 35-74% of it attributable to rare variants with minor allele frequencies between 0.01% and 1%. These heritability estimates are 1.5-4 times higher than past estimates based on common variants alone and accounted for 60% to 100% of our pedigree-based estimates of narrow-sense heritability ([Formula: see text], 0.18-0.34). In the African ancestry samples, [Formula: see text] was estimated from 0.03 to 0.33 (s.e., 0.09-0.14) across the four smoking traits. These results suggest that rare variants are important contributors to the heritability of smoking.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Jang, Seon-Kyeon ...
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Evans, Luke
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Fialkowski, Alli ...
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Arnett, Donna K
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Ashley-Koch, All ...
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Barnes, Kathleen ...
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show more...
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Becker, Diane M
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Bis, Joshua C
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Blangero, John
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Bleecker, Eugene ...
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Boorgula, Meher ...
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Bowden, Donald W
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Brody, Jennifer ...
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Cade, Brian E
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Jenkins, Brenda ...
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Carson, April P
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Chavan, Sameer
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Cupples, L Adrie ...
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Custer, Brian
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Damrauer, Scott ...
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David, Sean P
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de Andrade, Mari ...
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Dinardo, Carla L
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Fingerlin, Tasha ...
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Fornage, Myriam
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Freedman, Barry ...
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Garrett, Melanie ...
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Gharib, Sina A
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Glahn, David C
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Haessler, Jeffre ...
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Heckbert, Susan ...
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Hokanson, John E
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Hou, Lifang
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Hwang, Shih-Jen
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Hyman, Matthew C
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Judy, Renae
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Justice, Anne E
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Kaplan, Robert C
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Kardia, Sharon L ...
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Kelly, Shannon
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Kim, Wonji
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Kooperberg, Char ...
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Levy, Daniel
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Lloyd-Jones, Don ...
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Loos, Ruth J F
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Manichaikul, Ani ...
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Gladwin, Mark T
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Martin, Lisa War ...
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Nouraie, Mehdi
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Melander, O.
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Meyers, Deborah ...
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Montgomery, Cour ...
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North, Kari E
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Oelsner, Elizabe ...
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Palmer, Nicholet ...
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Payton, Marinell ...
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Peljto, Anna L
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Peyser, Patricia ...
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Preuss, Michael
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Psaty, Bruce M
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Qiao, Dandi
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Rader, Daniel J
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Rafaels, Nichola ...
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Redline, Susan
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Reed, Robert M
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Reiner, Alexande ...
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Rich, Stephen S
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Rotter, Jerome I
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Schwartz, David ...
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Shadyab, Aladdin ...
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Silverman, Edwin ...
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Smith, Nicholas ...
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Smith, J. Gustav ...
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Smith, Albert V
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Smith, Jennifer ...
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Tang, Weihong
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Taylor, Kent D
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Telen, Marilyn J
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Vasan, Ramachand ...
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Gordeuk, Victor ...
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Wang, Zhe
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Wiggins, Kerri L
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Yanek, Lisa R
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Yang, Ivana V
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Young, Kendra A
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Young, Kristin L
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Zhang, Yingze
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Liu, Dajiang J
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Keller, Matthew ...
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Vrieze, Scott
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Nature human beh ...
- By the university
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University of Gothenburg
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Lund University