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Sökning: WFRF:(D’Amario Domenico) > (2019) > Prevalence and Prog...

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FältnamnIndikatorerMetadata
00005316naa a2200505 4500
001oai:DiVA.org:uu-381568
003SwePub
008190416s2019 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:140584119
009oai:DiVA.org:liu-156193
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3815682 URI
0247 a https://doi.org/10.1016/j.jchf.2018.11.0192 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1405841192 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1561932 URI
040 a (SwePub)uud (SwePub)kid (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Savarese, Gianluigiu Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden4 aut
2451 0a Prevalence and Prognostic Implications of Longitudinal Ejection Fraction Change in Heart Failure
264 1b ELSEVIER SCI LTD,c 2019
338 a print2 rdacarrier
500 a Funding Agencies|Swedish Research Council [2013-23897-104604-23, 523-2014-2336]; Swedish Heart Lung Foundation [20120321, 20150557]; Stockholm County Council [20110120]
520 a OBJECTIVES: This study sought to evaluate the incidence, the predictors, and the associations with outcomes of changes in ejection fraction (EF) in heart failure (HF) patients.BACKGROUND: EF determines therapy in HF, but information is scarce about incidence, determinants, and prognostic implications of EF change over time.METHODS: Patients with >= 2 EF measurements were made in the Swedish Heart Failure Registry were categorized as heart failure with preserved ejection fraction (HFpEF) (EF >= 50%), heart failure with midrange ejection fraction (HFmrEF) (EF 40% to 49%), or heart failure with reduced ejection fraction (HFrEF) (EF <40%). Changes among categories were recorded, and associations among EF changes, predictors, and all-cause mortality and/or HF hospitalizations were analyzed using logistic and Cox regressions.RESULTS: Of 4,942 patients at baseline, 18% had HFpEF, 19% had HFmrEF, and 63% had HFrEF. During follow-up, 21% and 18% of HFpEF patients transitioned to HFmrEF and HFrEF, respectively; 37% and 25% of HFmrEF patients transitioned to HFrEF and HFpEF, respectively; and 16% and 10% of HFrEF patients transitioned to HFmrEF and HFpEF, respectively. Predictors of increased EF included use of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, female sex, cases of less severe HF, and comorbidities. Predictors of decreased EF included diabetes, ischemic heart disease, and cases of more severe HF. Increased EF was associated with a lower risk (hazard ratio [HR]: 0.62; 95% confidence interval [CI]: 0.55 to 0.69) and decreased EF with a higher risk (HR: 1.15; 95% CI: 1.01 to 1.30) of mortality and/or HF hospitalizations. Prognostic implications were most evident for transitions to and from HFrEF.CONCLUSIONS: Increases in EF occurred in one-fourth of HFrEF and HFmrEF patients, and decreases occurred in more than one-third of patients with HFpEF and HFmrEF. EF change was associated with a wide range of important clinical, treatment, and organizational factors as well as with outcomes, particularly transitions to and from HFrEF.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a ejection fraction
653 a heart failure
653 a predictors
653 a prognosis
7001 a Vedin, Olau Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR),Boehringer Ingelheim AB, Stockholm, Sweden,Uppsala Univ, Sweden; Uppsala Clin Res Ctr, Sweden; Boehringer Ingelheim AB, Sweden4 aut0 (Swepub:uu)olved933
7001 a D'Amario, Domenicou Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli, Inst Cardiol, Inst Sci Res & Treatment, Rome, Italy4 aut
7001 a Uijl, Aliciau Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden; Univ Utrecht, Netherlands4 aut
7001 a Dahlström, Ulfu Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US4 aut0 (Swepub:liu)ulfda85
7001 a Rosano, Giuseppeu IRCCS San Raffaele Hosp, Dept Med Sci, Rome, Italy4 aut
7001 a Lam, Carolyn S. P.u Duke NUS Med Sch, Natl Heart Ctr Singapore, Singapore, Singapore;Univ Med Ctr Groningen, Groningen, Netherlands4 aut
7001 a Lund, Lars H.u Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden4 aut
7102 a Karolinska Institutetb Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden4 org
7730 t JACC. Heart failured : ELSEVIER SCI LTDg 7:4, s. 306-317q 7:4<306-317x 2213-1779x 2213-1787
8564 u https://doi.org/10.1016/j.jchf.2018.11.019
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-381568
8564 8u https://doi.org/10.1016/j.jchf.2018.11.019
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:140584119
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-156193

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