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Markedly reduced ch...
Markedly reduced chronic nociceptive response in mice lacking the PAC1 receptor
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Jongsma, Helen (författare)
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- Pettersson, Lina (författare)
- Lund University,Lunds universitet,Neurala gränsytor,Forskargrupper vid Lunds universitet,Neurofysiologi,Neural Interfaces,Lund University Research Groups,Neurophysiology
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- Kvist Reimer, Martina (författare)
- Lund University,Lunds universitet,Medicinska fakulteten,Faculty of Medicine
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visa fler...
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- Kanje, Martin (författare)
- Lund University,Lunds universitet,Funktionell zoologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Functional zoology,Department of Biology,Faculty of Science
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- Waldenström Ellervik, Alexandra (författare)
- Lund University,Lunds universitet,Neurofysiologi,Forskargrupper vid Lunds universitet,Neurophysiology,Lund University Research Groups
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- Sundler, Frank (författare)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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- Danielsen, Nils (författare)
- Lund University,Lunds universitet,Neurala gränsytor,Forskargrupper vid Lunds universitet,Neural Interfaces,Lund University Research Groups
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visa färre...
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(creator_code:org_t)
- 2001
- 2001
- Engelska.
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Ingår i: NeuroReport. - 1473-558X. ; 12:10, s. 2215-2219
- Relaterad länk:
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https://lup.lub.lu.s...
Abstract
Ämnesord
Stäng
- The neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) has been proposed to have a role in nociception. Here we have used the formalin test, thermal laser stimulation and mechanical von Frey stimulation to investigate possible alteration of PAC1-/- mice nociceptive behaviour. Our finding, that PAC1-/- mice have a substantial, 75% decrease in nociceptive response during the late phase, provides clear evidence that the specific PACAP-receptor PAC1 is involved in the mediation of nociceptive responses during chronic conditions such as inflammation. PAC1-/- mice had small or no changes in the response to mechanical and thermal laser stimulation. This suggests a limited, if any, involvement of PAC1 in nociception after short-lasting stimuli. Injury-induced changes in DRG neuropeptide expression were more pronounced in PAC1-/- mice, implying neuroregulatory functions of PAC1.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Dorsal root ganglion
- Formalin test
- Inflammation
- Mechanical von Frey
- Neuropeptides
- PACAP
- Pain measurements
- Sciatic nerve injury
- Sensory thresholds
- Thermal laser
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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