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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 09232naa a2202293 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:148720743 | |
| 003 | SwePub | |
| 008 | 240701s2022 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:65a01606-fd98-4834-a62a-817b78fbb02d | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1487207432 URI |
| 024 | 7 | a https://doi.org/10.1093/jnci/djab1472 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/65a01606-fd98-4834-a62a-817b78fbb02d2 URI |
| 040 | a (SwePub)kid (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Barnes, DRu University of Cambridge4 aut |
| 245 | 1 0 | a Breast and Prostate Cancer Risks for Male BRCA1 and BRCA2 Pathogenic Variant Carriers Using Polygenic Risk Scores |
| 264 | c 2021-07-28 | |
| 264 | 1 | b Oxford University Press (OUP),c 2022 |
| 520 | a BackgroundRecent population-based female breast cancer and prostate cancer polygenic risk scores (PRS) have been developed. We assessed the associations of these PRS with breast and prostate cancer risks for male BRCA1 and BRCA2 pathogenic variant carriers.Methods483 BRCA1 and 1318 BRCA2 European ancestry male carriers were available from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). A 147-single nucleotide polymorphism (SNP) prostate cancer PRS (PRSPC) and a 313-SNP breast cancer PRS were evaluated. There were 3 versions of the breast cancer PRS, optimized to predict overall (PRSBC), estrogen receptor (ER)–negative (PRSER-), or ER-positive (PRSER+) breast cancer risk.ResultsPRSER+ yielded the strongest association with breast cancer risk. The odds ratios (ORs) per PRSER+ standard deviation estimates were 1.40 (95% confidence interval [CI] =1.07 to 1.83) for BRCA1 and 1.33 (95% CI = 1.16 to 1.52) for BRCA2 carriers. PRSPC was associated with prostate cancer risk for BRCA1 (OR = 1.73, 95% CI = 1.28 to 2.33) and BRCA2 (OR = 1.60, 95% CI = 1.34 to 1.91) carriers. The estimated breast cancer odds ratios were larger after adjusting for female relative breast cancer family history. By age 85 years, for BRCA2 carriers, the breast cancer risk varied from 7.7% to 18.4% and prostate cancer risk from 34.1% to 87.6% between the 5th and 95th percentiles of the PRS distributions.ConclusionsPopulation-based prostate and female breast cancer PRS are associated with a wide range of absolute breast and prostate cancer risks for male BRCA1 and BRCA2 carriers. These findings warrant further investigation aimed at providing personalized cancer risks for male carriers and informing clinical management. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 700 | 1 | a Silvestri, V4 aut |
| 700 | 1 | a Leslie, G4 aut |
| 700 | 1 | a McGuffog, L4 aut |
| 700 | 1 | a Dennis, J4 aut |
| 700 | 1 | a Yang, X4 aut |
| 700 | 1 | a Adlard, J4 aut |
| 700 | 1 | a Borg, A.u Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments4 aut0 (Swepub:lu)onk-abo |
| 700 | 1 | a Ahmed, M4 aut |
| 700 | 1 | a Aittomaki, K4 aut |
| 700 | 1 | a Andrulis, IL4 aut |
| 700 | 1 | a Arason, A4 aut |
| 700 | 1 | a Arnold, N4 aut |
| 700 | 1 | a Auber, B4 aut |
| 700 | 1 | a Azzollini, J4 aut |
| 700 | 1 | a Balmana, J4 aut |
| 700 | 1 | a Barkardottir, RB4 aut |
| 700 | 1 | a Barrowdale, D4 aut |
| 700 | 1 | a Barwell, J4 aut |
| 700 | 1 | a Belotti, M4 aut |
| 700 | 1 | a Benitez, J4 aut |
| 700 | 1 | a Berthet, P4 aut |
| 700 | 1 | a Boonen, SE4 aut |
| 700 | 1 | a Borg, A4 aut |
| 700 | 1 | a Bozsik, A4 aut |
| 700 | 1 | a Brady, AF4 aut |
| 700 | 1 | a Brennan, P4 aut |
| 700 | 1 | a Brewer, C4 aut |
| 700 | 1 | a Brunet, J4 aut |
| 700 | 1 | a Bucalo, A4 aut |
| 700 | 1 | a Buys, SS4 aut |
| 700 | 1 | a Caldes, T4 aut |
| 700 | 1 | a Caligo, MA4 aut |
| 700 | 1 | a Campbell, I4 aut |
| 700 | 1 | a Cassingham, H4 aut |
| 700 | 1 | a Christensen, LL4 aut |
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| 700 | 1 | a Claes, KBM4 aut |
| 700 | 1 | a Cook, J4 aut |
| 700 | 1 | a Coppa, A4 aut |
| 700 | 1 | a Cortesi, L4 aut |
| 700 | 1 | a Damante, G4 aut |
| 700 | 1 | a Darder, E4 aut |
| 700 | 1 | a Davidson, R4 aut |
| 700 | 1 | a de la Hoya, M4 aut |
| 700 | 1 | a De Leeneer, K4 aut |
| 700 | 1 | a de Putter, R4 aut |
| 700 | 1 | a Del Valle, J4 aut |
| 700 | 1 | a Diez, O4 aut |
| 700 | 1 | a Ding, YC4 aut |
| 700 | 1 | a Domchek, SM4 aut |
| 700 | 1 | a Donaldson, A4 aut |
| 700 | 1 | a Eason, J4 aut |
| 700 | 1 | a Eeles, R4 aut |
| 700 | 1 | a Engel, C4 aut |
| 700 | 1 | a Evans, DG4 aut |
| 700 | 1 | a Feliubadalo, L4 aut |
| 700 | 1 | a Fostira, F4 aut |
| 700 | 1 | a Frone, M4 aut |
| 700 | 1 | a Frost, D4 aut |
| 700 | 1 | a Gallagher, D4 aut |
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| 700 | 1 | a Giraud, S4 aut |
| 700 | 1 | a Glendon, G4 aut |
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| 700 | 1 | a Hamann, U4 aut |
| 700 | 1 | a Hansen, TVO4 aut |
| 700 | 1 | a Hanson, H4 aut |
| 700 | 1 | a Hentschel, J4 aut |
| 700 | 1 | a Horvath, J4 aut |
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| 700 | 1 | a Izquierdo, A4 aut |
| 700 | 1 | a James, PA4 aut |
| 700 | 1 | a Janavicius, R4 aut |
| 700 | 1 | a Jensen, UB4 aut |
| 700 | 1 | a Johannsson, OT4 aut |
| 700 | 1 | a John, EM4 aut |
| 700 | 1 | a Kramer, G4 aut |
| 700 | 1 | a Kroeldrup, L4 aut |
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| 700 | 1 | a Lautrup, C4 aut |
| 700 | 1 | a Lazaro, C4 aut |
| 700 | 1 | a Lesueur, F4 aut |
| 700 | 1 | a Lopez-Fernandez, A4 aut |
| 700 | 1 | a Mai, PL4 aut |
| 700 | 1 | a Manoukian, S4 aut |
| 700 | 1 | a Matrai, Z4 aut |
| 700 | 1 | a Matricardi, L4 aut |
| 700 | 1 | a Maxwell, KN4 aut |
| 700 | 1 | a Mebirouk, N4 aut |
| 700 | 1 | a Meindl, A4 aut |
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| 700 | 1 | a Monteiro, AN4 aut |
| 700 | 1 | a Morrison, PJ4 aut |
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| 700 | 1 | a Murray, A4 aut |
| 700 | 1 | a Nathanson, KL4 aut |
| 700 | 1 | a Neuhausen, SL4 aut |
| 700 | 1 | a Nevanlinna, H4 aut |
| 700 | 1 | a Tu, ND4 aut |
| 700 | 1 | a Niederacher, D4 aut |
| 700 | 1 | a Olah, E4 aut |
| 700 | 1 | a Olopade, OI4 aut |
| 700 | 1 | a Palli, D4 aut |
| 700 | 1 | a Parsons, MT4 aut |
| 700 | 1 | a Pedersen, IS4 aut |
| 700 | 1 | a Peissel, B4 aut |
| 700 | 1 | a Perez-Segura, P4 aut |
| 700 | 1 | a Peterlongo, P4 aut |
| 700 | 1 | a Petersen, AH4 aut |
| 700 | 1 | a Pinto, P4 aut |
| 700 | 1 | a Porteous, ME4 aut |
| 700 | 1 | a Pottinger, C4 aut |
| 700 | 1 | a Pujana, MA4 aut |
| 700 | 1 | a Radice, P4 aut |
| 700 | 1 | a Ramser, J4 aut |
| 700 | 1 | a Rantala, Ju Karolinska Institutet4 aut |
| 700 | 1 | a Robson, M4 aut |
| 700 | 1 | a Rogers, MT4 aut |
| 700 | 1 | a Ronlund, K4 aut |
| 700 | 1 | a Rump, A4 aut |
| 700 | 1 | a de Abajo, AMS4 aut |
| 700 | 1 | a Shah, PD4 aut |
| 700 | 1 | a Sharif, S4 aut |
| 700 | 1 | a Side, LE4 aut |
| 700 | 1 | a Singer, CF4 aut |
| 700 | 1 | a Stadler, Z4 aut |
| 700 | 1 | a Steele, L4 aut |
| 700 | 1 | a Stoppa-Lyonnet, D4 aut |
| 700 | 1 | a Sutter, C4 aut |
| 700 | 1 | a Tan, YY4 aut |
| 700 | 1 | a Teixeira, MR4 aut |
| 700 | 1 | a Teule, A4 aut |
| 700 | 1 | a Thull, DL4 aut |
| 700 | 1 | a Tischkowitz, M4 aut |
| 700 | 1 | a Toland, AE4 aut |
| 700 | 1 | a Tommasi, S4 aut |
| 700 | 1 | a Toss, A4 aut |
| 700 | 1 | a Trainer, AH4 aut |
| 700 | 1 | a Tripathi, V4 aut |
| 700 | 1 | a Valentini, V4 aut |
| 700 | 1 | a van Asperen, CJ4 aut |
| 700 | 1 | a Venturelli, M4 aut |
| 700 | 1 | a Viel, A4 aut |
| 700 | 1 | a Vijai, J4 aut |
| 700 | 1 | a Walker, L4 aut |
| 700 | 1 | a Wang-Gohrke, S4 aut |
| 700 | 1 | a Wappenschmidt, B4 aut |
| 700 | 1 | a Whaite, A4 aut |
| 700 | 1 | a Zanna, I4 aut |
| 700 | 1 | a Offit, K4 aut |
| 700 | 1 | a Thomassen, M4 aut |
| 700 | 1 | a Couch, FJ4 aut |
| 700 | 1 | a Schmutzler, RK4 aut |
| 700 | 1 | a Simard, J4 aut |
| 700 | 1 | a Easton, DF4 aut |
| 700 | 1 | a Chenevix-Trench, G4 aut |
| 700 | 1 | a Antoniou, AC4 aut |
| 700 | 1 | a Ottini, Lu Sapienza University of Rome4 aut |
| 710 | 2 | a University of Cambridgeb Bröstcancer-genetik4 org |
| 773 | 0 | t Journal of the National Cancer Instituted : Oxford University Press (OUP)g 114:1, s. 109-122q 114:1<109-122x 1460-2105x 0027-8874 |
| 856 | 4 | u https://doi.org/10.1093/jnci/djab147 |
| 856 | 4 | u http://dx.doi.org/10.1093/jnci/djab147x freey FULLTEXT |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:148720743 |
| 856 | 4 8 | u https://doi.org/10.1093/jnci/djab147 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/65a01606-fd98-4834-a62a-817b78fbb02d |
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- Ahmed, M
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- Balmana, J
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- Berthet, P
- Boonen, SE
- Borg, A
- Bozsik, A
- Brady, AF
- Brennan, P
- Brewer, C
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- Bucalo, A
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- Caldes, T
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- Campbell, I
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- Christensen, LL
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- Claes, KBM
- Cook, J
- Coppa, A
- Cortesi, L
- Damante, G
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- Davidson, R
- de la Hoya, M
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- de Putter, R
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- Engel, C
- Evans, DG
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- Frone, M
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- Gallagher, D
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- Giraud, S
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- Greene, MH
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- Gross, E
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- Hanson, H
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- Izatt, L
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- James, PA
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- Morrison, PJ
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