Sökning: WFRF:(Deleanu D) > (2022) > Proposal of 0.5 mg ...
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000 | 16535naa a2201621 4500 | |
001 | oai:gup.ub.gu.se/310443 | |
003 | SwePub | |
008 | 240528s2022 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-486012 | |
009 | oai:prod.swepub.kib.ki.se:148166584 | |
024 | 7 | a https://gup.ub.gu.se/publication/3104432 URI |
024 | 7 | a https://doi.org/10.1111/all.151672 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4860122 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1481665842 URI |
040 | a (SwePub)gud (SwePub)uud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Zuberbier, T.u Charite Univ Med Berlin, Dept Dermatol & Allergy, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Berlin Inst Hlth, Comprehens Allergy Ctr, Berlin, Germany4 aut |
245 | 1 0 | a Proposal of 0.5 mg of protein/100 g of processed food as threshold for voluntary declaration of food allergen traces in processed food-A first step in an initiative to better inform patients and avoid fatal allergic reactions: A GA(2)LEN position paper |
264 | c 2021-11-24 | |
264 | 1 | b Wiley,c 2022 |
520 | a Background Food anaphylaxis is commonly elicited by unintentional ingestion of foods containing the allergen above the tolerance threshold level of the individual. While labeling the 14 main allergens used as ingredients in food products is mandatory in the EU, there is no legal definition of declaring potential contaminants. Precautionary allergen labeling such as "may contain traces of" is often used. However, this is unsatisfactory for consumers as they get no information if the contamination is below their personal threshold. In discussions with the food industry and technologists, it was suggested to use a voluntary declaration indicating that all declared contaminants are below a threshold of 0.5 mg protein per 100 g of food. This concentration is known to be below the threshold of most patients, and it can be technically guaranteed in most food production. However, it was also important to assess that in case of accidental ingestion of contaminants below this threshold by highly allergic patients, no fatal anaphylactic reaction could occur. Therefore, we performed a systematic review to assess whether a fatal reaction to 5mg of protein or less has been reported, assuming that a maximum portion size of 1kg of a processed food exceeds any meal and thus gives a sufficient safety margin. Methods MEDLINE and EMBASE were searched until 24 January 2021 for provocation studies and case reports in which one of the 14 major food allergens was reported to elicit fatal or life-threatening anaphylactic reactions and assessed if these occurred below the ingestion of 5mg of protein. A Delphi process was performed to obtain an expert consensus on the results. Results In the 210 studies included, in our search, no reports of fatal anaphylactic reactions reported below 5 mg protein ingested were identified. However, in provocation studies and case reports, severe reactions below 5 mg were reported for the following allergens: eggs, fish, lupin, milk, nuts, peanuts, soy, and sesame seeds. Conclusion Based on the literature studied for this review, it can be stated that cross-contamination of the 14 major food allergens below 0.5 mg/100 g is likely not to endanger most food allergic patients when a standard portion of food is consumed. We propose to use the statement "this product contains the named allergens in the list of ingredients, it may contain traces of other contaminations (to be named, e.g. nut) at concentrations less than 0.5 mg per 100 g of this product" for a voluntary declaration on processed food packages. This level of avoidance of cross-contaminations can be achieved technically for most processed foods, and the statement would be a clear and helpful message to the consumers. However, it is clearly acknowledged that a voluntary declaration is only a first step to a legally binding solution. For this, further research on threshold levels is encouraged. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng |
653 | a anaphylaxis | |
653 | a food allergy | |
653 | a nutrition | |
653 | a exercise-induced anaphylaxis | |
653 | a cows milk | |
653 | a oral immunotherapy | |
653 | a peanut | |
653 | a allergy | |
653 | a challenge | |
653 | a children | |
653 | a diagnosis | |
653 | a adolescents | |
653 | a sesame | |
653 | a tests | |
653 | a Allergy | |
653 | a Immunology | |
653 | a anaphylaxis | |
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700 | 1 | a Aberer, W.u Med Univ Graz, Dept Dermatol, Graz, Austria4 aut |
700 | 1 | a Alvaro, M.u Hosp St Joan de Deu, Serv Allergol Immunol Clin, Barcelona, Spain4 aut |
700 | 1 | a Angier, E.u Univ Southampton, Fac Med, Primary Care Populat Sci & Med Educ, Southampton, Hants, England4 aut |
700 | 1 | a Arasi, S.u Bambino Gesu Hosp IRCCS, Pediat Allergol Unit, Rome, Italy4 aut |
700 | 1 | a Arshad, H.u Univ Hosp Southampton NHS Fdn Trust, NIHR Southampton Biomed Res Ctr, Southampton, Hants, England.;Univ Southampton, Fac Med, Clin & Expt Sci, Southampton, Hants, England.;St Marys Hosp, David Hide Asthma & Allergy Res Ctr, Newport, Wight, England4 aut |
700 | 1 | a Ballmer-Weber, B.u Univ Hosp Zurich, Dept Dermatol, Zurich, Switzerland.;Kantonsspital St Gallen, Clin Dermatol & Allergol, St Gallen, Switzerland4 aut |
700 | 1 | a Bartra, J.u Hosp Clin Barcelona, Serv Neumol & Allergia Resp, Unitat Allergia, Barcelona, Spain.;Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain4 aut |
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700 | 1 | a Begin, P.u CHU St Justine, Montreal, PQ, Canada4 aut |
700 | 1 | a Janson, Christeru Uppsala universitet,Lung- allergi- och sömnforskning,Klinisk fysiologi4 aut0 (Swepub:uu)chrisjn |
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700 | 1 | a Bousquet, J.u Charite Univ Med Berlin, Dept Dermatol & Allergy, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Berlin Inst Hlth, Comprehens Allergy Ctr, Berlin, Germany.;Univ Hosp Montpellier, Montpellier, France.;MACVIA France, Montpellier, France4 aut |
700 | 1 | a Brockow, K.u Tech Univ Munich, Sch Med, Dept Dermatol & Allergy Biederstein, Munich, Germany4 aut |
700 | 1 | a Bush, A.u Imperial Coll, London, England.;Royal Brompton Hosp, London, England4 aut |
700 | 1 | a Cianferoni, A.u Univ Penn, Dept Pediat, Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA4 aut |
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700 | 1 | a Darsow, U.u Tech Univ Munich, Sch Med, Dept Dermatol & Allergy Biederstein, Munich, Germany4 aut |
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700 | 1 | a Galvin, A. D.u Univ Coll Cork, Cork, Ireland.;Sechenov Univ Moscow, Moscow, Russia.;Anaphylaxis Ireland, Cork, Ireland4 aut |
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700 | 1 | a Fernandez-Rivas, M.u Univ Complutense UCM, Hosp Clin San Carlos, Fac Med, Allergy Dept,IdISSC, Madrid, Spain4 aut |
700 | 1 | a Ferrer, M.u Clin Univ Navarra, Dept Allergy, Pamplona, Spain4 aut |
700 | 1 | a Fiocchi, A.u Bambino Gesu Hosp IRCCS, Pediat Allergol Unit, Rome, Italy4 aut |
700 | 1 | a van Wijk, R. G.u Erasmus MC, Sect Allergol & Clin Immunol, Dept Internal Med, Rotterdam, Netherlands,Univ Bologna, Dept Med & Surg Sci, Pediat Unit, Bologna, Italy,Univ Amsterdam, Acad Med Ctr, Dept Expt Immunol, Amsterdam, Netherlands.;Univ Amsterdam, Acad Med Ctr, Dept Otorhinolaryngol, Amsterdam, Netherlands4 aut |
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700 | 1 | a Janson, C.4 aut |
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700 | 1 | a Jones, C.4 aut |
700 | 1 | a Jutel, M.4 aut |
700 | 1 | a Katoh, N.u Kyoto Prefectural Univ Med, Dept Dermatol, Kyoto, Japan4 aut |
700 | 1 | a Kendziora, B.u Ludwig Maximilians Univ Munchen, Dept Dermatol & Allergy, Univ Hosp, Munich, Germany4 aut |
700 | 1 | a Kinaciyan, T.u Med Univ Vienna, Dept Dermatol, Vienna, Austria4 aut |
700 | 1 | a Knol, E.u Univ Med Ctr Utrecht, Dept Dermatol & Allergol, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Lab Translat Immunol, Utrecht, Netherlands4 aut |
700 | 1 | a Kurbacheva, O.u NRC Inst Immunol FMBA, Moscow, Russia4 aut |
700 | 1 | a Lau, S.u Charite Univ Med Berlin, Pediat Resp Med Immunol & Crit Care Med, Berlin, Germany4 aut |
700 | 1 | a Loh, R.u Univ Western Australia, Perth Childrens Hosp, Dept Immunol, Perth, WA, Australia4 aut |
700 | 1 | a Lombardi, C.u Ente Osped Fdn Poliambulanza, Unita Dipartimentale Allergol Immunol Clin & Mala, Brescia, Italy4 aut |
700 | 1 | a Makela, M.u Asthma & Allergy Assoc, Stockholm, Sweden4 aut |
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700 | 1 | a Mijakoski, D.u Ss Cyril & Methodius Univ Skopje, Fac Med, WHO Collaborating Ctr, Inst Occupat Hlth RNM, Skopje, North Macedonia4 aut |
700 | 1 | a Minov, J.4 aut |
700 | 1 | a Mullol, J.4 aut |
700 | 1 | a Nilsson, C.u Karolinska Institutet4 aut |
700 | 1 | a Nowak-Wegrzyn, A.u Icahn Sch Med Mt Sinai, Div Allergy & Immunol, Dept Pediat, Jaffe Food Allergy Inst,Kravis Childrens Hosp, New York, NY 10029 USA4 aut |
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700 | 1 | a Pajno, G. B.u Univ Messina, Pediat Unit, Policlin Hospitsl, Messina, Italy4 aut |
700 | 1 | a Paudel, S.u Civil Serv Hosp, Kathmandu, Nepal4 aut |
700 | 1 | a Papadopoulos, N. G.u Univ Athens, Allergy Dept, Pediat Clin 2, Athens, Greece4 aut |
700 | 1 | a Renz, H.u Philipps Univ Marburg, Inst Lab Med & Pathobiochem, Univ Hosp Giessen & Marburg, Mol Diagnost, Marburg, Germany.;Sechenov Univ, Dept Clin Immunol & Allergol, Lab Immunopathol, Moscow, Russia4 aut |
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700 | 1 | a Rogala, B.u Univ Silesia, Dept Internal Dis Allergol & Clin Immunol Med, Katowice, Poland4 aut |
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700 | 1 | a Smith, P. K.u Griffith Univ, Southport, Qld, Australia4 aut |
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700 | 1 | a Wong, G. W. K.u Chinese Univ Hong Kong, Dept Paediat, Hong Kong, Peoples R China4 aut |
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773 | 0 | t Allergyd : Wileyg 77:6, s. 1736-1750q 77:6<1736-1750x 0105-4538x 1398-9995 |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.15167 |
856 | 4 | u https://doi.org/10.1111/all.15167y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1702283/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://gup.ub.gu.se/publication/310443 |
856 | 4 8 | u https://doi.org/10.1111/all.15167 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-486012 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:148166584 |
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