WFRF:(Denz Cornelia)
Search: WFRF:(Denz Cornelia) > (2017) > Endoglin controls b...
- 1 of 1
- Previous record
- Next record
- To hitlist
Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues.
- Sugden, Wade W (author)
- Meissner, Robert (author)
- Aegerter-Wilmsen, Tinri (author)
- show more...
- Tsaryk, Roman (author)
- Leonard, Elvin V (author)
- Bussmann, Jeroen (author)
- Hamm, Mailin J (author)
- Herzog, Wiebke (author)
- Denz, Cornelia (author)
- Siekmann, Arndt F (author)
- show less...
- (creator_code:org_t)
- 2017-05-22
- 2017
- English.
- In: Nature Cell Biology. - : Springer Science and Business Media LLC. - 1465-7392 .- 1476-4679. ; 19:6, s. 653-665
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The hierarchical organization of properly sized blood vessels ensures the correct distribution of blood to all organs of the body, and is controlled via haemodynamic cues. In current concepts, an endothelium-dependent shear stress set point causes blood vessel enlargement in response to higher flow rates, while lower flow would lead to blood vessel narrowing, thereby establishing homeostasis. We show that during zebrafish embryonic development increases in flow, after an initial expansion of blood vessel diameters, eventually lead to vessel contraction. This is mediated via endothelial cell shape changes. We identify the transforming growth factor beta co-receptor endoglin as an important player in this process. Endoglin mutant cells and blood vessels continue to enlarge in response to flow increases, thus exacerbating pre-existing embryonic arterial-venous shunts. Together, our data suggest that cell shape changes in response to biophysical cues act as an underlying principle allowing for the ordered patterning of tubular organs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Nature Cell Biology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Sugden, Wade W
- Meissner, Robert
- Aegerter-Wilmsen ...
- Tsaryk, Roman
- Leonard, Elvin V
- Bussmann, Jeroen
- show more...
- Hamm, Mailin J
- Herzog, Wiebke
- Jin, Yi
- Jakobsson, Lars
- Denz, Cornelia
- Siekmann, Arndt ...
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Cell and Molecul ...
- Articles in the publication
- Nature Cell Biol ...
- By the university
- Uppsala University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
