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Sökning: WFRF:(Derakhshan Arash) > (2018) > Reference ranges an...

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FältnamnIndikatorerMetadata
00006467naa a2200553 4500
001oai:DiVA.org:oru-68366
003SwePub
008180813s2018 | |||||||||||000 ||eng|
009oai:DiVA.org:su-161115
009oai:DiVA.org:kau-69473
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-683662 URI
0247 a https://doi.org/10.1210/jc.2018-008902 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1611152 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-694732 URI
040 a (SwePub)orud (SwePub)sud (SwePub)kau
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Derakhshan, Arashu Academic Center for Thyroid Diseases, Erasmus MC, Rotterdam, The Netherlands; Department of internal Medicine, Erasmus MC, Rotterdam, The Netherlands,rasmus MC, Acad Ctr Thyroid Dis, NL-3051 GE Rotterdam, Netherland4 aut
2451 0a Reference ranges and determinants of thyroid function during early pregnancy :b the SELMA study
264 c 2018-07-02
264 1b Oxford University Press,c 2018
338 a print2 rdacarrier
500 a Funding Agencies:Exchange in Endocrinology Expertise (3E) program of the European Union of Medical Specialists (UEMS), Section and Board of Endocrinology  ZOnMW VIDI  016.176.331 Erasmus MC MRACE grant  County Council of Värmland, Sweden 
520 a Context: Establishing reference ranges as well as identifying and quantifying the determinants of thyroid function during pregnancy is important for proper clinical interpretation and optimizing research efforts. However, such data are sparse, specifically for (F)T3 measurements and most studies do not take into account thyroid antibodies or hCG.Objective: To determine reference ranges and to identify/quantify determinants of TSH, FT4, FT3, TT4 and TT3.Design, Setting and Participants: This study included 2,314 participants of the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy study, a population-based prospective pregnancy cohort of mother-child pairs. Reference ranges were calculated by 2.5-97.5th percentiles after excluding TPOAb and/or TgAb positive women.Intervention: None.Main Outcome Measures: TSH, FT4, FT3, TT4 and TT3 in prenatal serum.Results: After exclusion of TPOAb positive women, reference range were: TSH: 0.11-3.48 mU/L, FT4: 11.6-19.4 pmol/L, FT3: 3.72-5.92 pg/mL, TT4: 82.4-166.2 pmol/L and TT3: 1.28-2.92 nmol/L. Additional exclusion of TgAb positive women did not change the reference ranges substantially. Exposure to tobacco smoke, as assessed by questionnaires and serum cotinine, was associated with lower TSH and higher FT3 and TT3. BMI and gestational age were the main determinants of TSH (only for BMI), FT4, FT3, TT4 and TT3.Conclusions: We show that the exclusion of TgAb positive women on top of excluding TPOAb positive women hardly affects clinical reference ranges. We identified various relevant clinical determinants of TSH, FT4, FT3, TT4 and TT3 which could reflect endocrine disrupting effects and/or effects on thyroid hormone transport or deiodination.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653 a Public Health Science
7001 a Shu, Huanu Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi4 aut0 (Swepub:su)hush5382
7001 a Broeren, Maarten A. C.u Laboratory of Clinical Chemistry and Haematology, Máxima Medical Centre, Veldhoven, De Run, The Netherlands,Maxima Med Ctr, Lab Clin Chem & Haematol, NL-5504 DB Veldhoven, Netherlands4 aut
7001 a de Poortere, Ralph A.u Laboratory of Clinical Chemistry and Haematology, Máxima Medical Centre, Veldhoven, De Run, The Netherlands,Maxima Med Ctr, Lab Clin Chem & Haematol, NL-5504 DB Veldhoven, Netherlands4 aut
7001 a Wikström, Sverre,d 1978-u Örebro universitet,Institutionen för medicinska vetenskaper,Örebro University4 aut0 (Swepub:oru)sewm
7001 a Peeters, Robin P.u Academic Center for Thyroid Diseases, Erasmus MC, Rotterdam, The Netherlands; Department of internal Medicine, Erasmus MC, Rotterdam, The Netherlands,rasmus MC, Acad Ctr Thyroid Dis, NL-3051 GE Rotterdam, Netherland4 aut
7001 a Demeneix, Barbarau Laboratoire d'Evolution des Régulations Endocriniennes, Muséum National d'Histoire Naturelle, Paris, France,Museum Natl Hist Nat, Lab Evolut Regulat Endocriniennes, Paris4 aut
7001 a Bornehag, Carl-Gustaf,d 1957-u Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Icahn Sch Med Mt Sinai, New York, NY4 aut0 (Swepub:kau)caguborn
7001 a Korevaar, Tim I. M.u Academic Center for Thyroid Diseases, Erasmus MC, Rotterdam, The Netherlands; Department of internal Medicine, Erasmus MC, Rotterdam, The Netherlands,Erasmus MC, Acad Ctr Thyroid Dis, NL-3051 GE Rotterdam, Netherlands4 aut
7102 a Academic Center for Thyroid Diseases, Erasmus MC, Rotterdam, The Netherlands; Department of internal Medicine, Erasmus MC, Rotterdam, The Netherlandsb rasmus MC, Acad Ctr Thyroid Dis, NL-3051 GE Rotterdam, Netherland4 org
7730 t Journal of Clinical Endocrinology and Metabolismd : Oxford University Pressg 103:9, s. 3548-3556q 103:9<3548-3556x 0021-972Xx 1945-7197
8564 u https://academic.oup.com/jcem/article-pdf/103/9/3548/25685998/jc.2018-00890.pdf
8564 u https://doi.org/10.1210/jc.2018-00890y Fulltext
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-68366
8564 8u https://doi.org/10.1210/jc.2018-00890
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-161115
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-69473

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