Sökning: WFRF:(Desaix Helena) > GAD65 antigen thera...
Fältnamn | Indikatorer | Metadata |
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000 | 08705naa a2201225 4500 | |
001 | oai:DiVA.org:liu-89965 | |
003 | SwePub | |
008 | 130312s2012 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:de435ab5-1cd0-439f-a07b-2e8f2a47b88f | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-899652 URI |
024 | 7 | a https://doi.org/10.1056/NEJMoa11070962 DOI |
024 | 7 | a https://lup.lub.lu.se/record/de435ab5-1cd0-439f-a07b-2e8f2a47b88f2 URI |
040 | a (SwePub)liud (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Ludvigsson, Johnnyu Linköping University,Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping4 aut0 (Swepub:liu)johlu29 |
245 | 1 0 | a GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus |
264 | 1 | b Massachusetts Medical Society,c 2012 |
338 | a print2 rdacarrier | |
500 | a Funding Agencies|Diamyd Medical||Swedish Child Diabetes Foundation (Barndiabetesfonden) | |
520 | a BACKGROUND: The 65-kD isoform of glutamic acid decarboxylase (GAD65) is a major autoantigen in type 1 diabetes. We hypothesized that alum-formulated GAD65 (GAD-alum) can preserve beta-cell function in patients with recent-onset type 1 diabetes.METHODS: We studied 334 patients, 10 to 20 years of age, with type 1 diabetes, fasting C-peptide levels of more than 0.3 ng per milliliter (0.1 nmol per liter), and detectable serum GAD65 autoantibodies. Within 3 months after diagnosis, patients were randomly assigned to receive one of three study treatments: four doses of GAD-alum, two doses of GAD-alum followed by two doses of placebo, or four doses of placebo. The primary outcome was the change in the stimulated serum C-peptide level (after a mixed-meal tolerance test) between the baseline visit and the 15-month visit. Secondary outcomes included the glycated hemoglobin level, mean daily insulin dose, rate of hypoglycemia, and fasting and maximum stimulated C-peptide levels.RESULTS: The stimulated C-peptide level declined to a similar degree in all study groups, and the primary outcome at 15 months did not differ significantly between the combined active-drug groups and the placebo group (P=0.10). The use of GAD-alum as compared with placebo did not affect the insulin dose, glycated hemoglobin level, or hypoglycemia rate. Adverse events were infrequent and mild in the three groups, with no significant differences.CONCLUSIONS: Treatment with GAD-alum did not significantly reduce the loss of stimulated C peptide or improve clinical outcomes over a 15-month period. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Krisky, Davidu Diamyd Medical, Pittsburgh,Diamyd Medical, US4 aut |
700 | 1 | a Casas, Rosaurau Linköping University,Linköpings universitet,Pediatrik,Hälsouniversitetet4 aut0 (Swepub:liu)rosca56 |
700 | 1 | a Battelino, Tadeju University Medical Center–University Children's Hospital, Faculty of Medicine, Ljubljana, Slovenia4 aut |
700 | 1 | a Castaño, Luisu Hospital de Cruces–University of Basque Country, Barakaldo, Bizkaia, Spain4 aut |
700 | 1 | a Greening, Jamesu Department of Paediatrics, Leicester Royal Infirmary, Leicester, UK4 aut |
700 | 1 | a Kordonouri, Olgau Diabetes Center for Children and Adolescents, Kinderkrankenhaus auf der Bult, Hannover, Germany,Children's Hospital Auf der Bult4 aut |
700 | 1 | a Otonkoski, Timou Children's Hospital, University of Helsinki, and Helsinki University Central Hospital, Helsinki, Finland4 aut |
700 | 1 | a Pozzilli, Paolou University Campus Bio-Medico, Rome, Italy4 aut |
700 | 1 | a Robert, Jean-Jacquesu Hôpital Necker–Enfants Malades, Université René Descartes Paris 5, Paris, France4 aut |
700 | 1 | a Veeze, Henk J.u Stichting Diabeter, Rotterdam, the Netherlands4 aut |
700 | 1 | a Palmer, Jerryu Department of Medicine, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, USA4 aut |
700 | 1 | a Samuelsson, Ulfu Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping4 aut0 (Swepub:liu)ulfsa43 |
700 | 1 | a Elding Larsson, Helenau Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)pedi-hla |
700 | 1 | a Åman, Janu Örebro universitet, Sweden4 aut |
700 | 1 | a Kärdell, Gunilla4 aut |
700 | 1 | a Neiderud, Janu Helsingborgs lasarett, Sweden4 aut |
700 | 1 | a Lundström, Göranu Länssjukhuset Kalmar, Sweden4 aut |
700 | 1 | a Albinsson, Evau Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet4 aut0 (Swepub:liu)evaal82 |
700 | 1 | a Carlsson, Annelieu Lund University,Lunds universitet,Pediatrisk autoimmunitet,Forskargrupper vid Lunds universitet,Pediatric Autoimmunity,Lund University Research Groups4 aut0 (Swepub:lu)med-acs |
700 | 1 | a Nordvall, Mariau Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Norrköping4 aut |
700 | 1 | a Fors, Hansu Sahlgrenska akademin vid Göteborgs universitet, Sweden4 aut |
700 | 1 | a Arvidsson, Carl-Göranu Centrallasarettet, Västerås, Sweden4 aut |
700 | 1 | a Edvardson, Stigu Centrallasarettet, Växjö, Sweden4 aut |
700 | 1 | a Hanås, Ragnaru Linköpings universitet,Pediatrik,Hälsouniversitetet4 aut0 (Swepub:liu)ragha78 |
700 | 1 | a Larsson, Karin4 aut |
700 | 1 | a Rathsman, Björnu Sachsska Barnsjukhuset, Stockholm, Sweden4 aut |
700 | 1 | a Forsgren, Henrik4 aut |
700 | 1 | a Desaix, Helena4 aut |
700 | 1 | a Forsander, Gunu Göteborg University, Sweden4 aut |
700 | 1 | a Nilsson, Nils-Östenu Lasarettet i Halmstad, Sweden4 aut |
700 | 1 | a Åkesson, Carl-Göran4 aut |
700 | 1 | a Keskinen, Päiviu University of Tampere, Finland4 aut |
700 | 1 | a Veijola, Riittau Uleåborgs universitetssjukhus, Finland4 aut |
700 | 1 | a Talvitie, Timo4 aut |
700 | 1 | a Raile, Klemensu Charite, Berlin, Germany4 aut |
700 | 1 | a Kapellen, Thomasu University of Leipzig, Germany4 aut |
700 | 1 | a Burger, Walter4 aut |
700 | 1 | a Neu, Andreasu University Children's Hospital, Tuebingen, Germany4 aut |
700 | 1 | a Engelsberger, Ilse4 aut |
700 | 1 | a Heidtmann, Bettinau Catholic Children’s Hospital Wilhelmstift, Hamburg, Germany4 aut |
700 | 1 | a Bechtold, Suzanne4 aut |
700 | 1 | a Leslie, Davidu Blizard Institute, Queen Mary University of London, UK4 aut |
700 | 1 | a Chiarelli, Francescou University of Chieti, Italy4 aut |
700 | 1 | a Cicognani, Alesandrou University of Bologna, Italy4 aut |
700 | 1 | a Chiumello, Giuseppeu Vita-Salute University, Milan, Italy4 aut |
700 | 1 | a Cerutti, Francou University of Turin, Italy4 aut |
700 | 1 | a Zuccotti, Gian Vincenzou University of Milan, Italy4 aut |
700 | 1 | a Gomez Gila, Ana4 aut |
700 | 1 | a Rica, Itxaso4 aut |
700 | 1 | a Barrio, Raquel4 aut |
700 | 1 | a Clemente, Maria4 aut |
700 | 1 | a López Garcia, Maria José4 aut |
700 | 1 | a Rodriguez, Mercedes4 aut |
700 | 1 | a Gonzalez, Isabel4 aut |
700 | 1 | a Lopez, Juan Pedro4 aut |
700 | 1 | a Oyarzabal, Mirentxu4 aut |
700 | 1 | a Reeser, H M4 aut |
700 | 1 | a Nuboer, Roos4 aut |
700 | 1 | a Stouthart, Pauline4 aut |
700 | 1 | a Bratina, Natasa4 aut |
700 | 1 | a Bratanic, Nina4 aut |
700 | 1 | a de Kerdanet, Marc4 aut |
700 | 1 | a Weill, Jacques4 aut |
700 | 1 | a Ser, Nicole4 aut |
700 | 1 | a Barat, Pascal4 aut |
700 | 1 | a Bertrand, Anne Marie4 aut |
700 | 1 | a Carel, Jean-Claude4 aut |
700 | 1 | a Reynaud, Rachel4 aut |
700 | 1 | a Coutant, Regis4 aut |
700 | 1 | a Baron, Sabine4 aut |
710 | 2 | a Linköpings universitetb Pediatrik4 org |
710 | 2 | a Co-authors |
773 | 0 | t New England Journal of Medicined : Massachusetts Medical Societyg 366:5, s. 433-442q 366:5<433-442x 0028-4793x 1533-4406 |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/22296077y Länk till posten i PubMed |
856 | 4 | u http://dx.doi.org/10.1056/NEJMoa1107096y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-89965 |
856 | 4 8 | u https://doi.org/10.1056/NEJMoa1107096 |
856 | 4 8 | u https://lup.lub.lu.se/record/de435ab5-1cd0-439f-a07b-2e8f2a47b88f |
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