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Distal aortic biome...
Distal aortic biomechanics after transcatheter versus surgical aortic valve replacement: a hypothesis generating study.
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Rong, Lisa Q (author)
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Zheng, William (author)
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Martinez, Andrew (author)
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Rahouma, Mohammed (author)
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Devereux, Richard B (author)
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Kim, Jiwon (author)
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Osman, Bassam (author)
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Palumbo, Maria C (author)
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- Redfors, Björn (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Girardi, Leonard N (author)
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Weinsaft, Jonathan W (author)
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Gaudino, Mario (author)
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Journal of cardiothoracic surgery. - 1749-8090. ; 18:1
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Biomechanical effects of transcatheter (TAVR) versus surgical (SAVR) aortic valve interventions on the distal aorta have not been studied. This study utilized global circumferential strain (GCS) to assess post-procedural biomechanics changes in the descending aorta after TAVR versus SAVR.Patients undergoing TAVR or SAVR for aortic stenosis were included. Transesophageal (TEE) and transthoracic (TTE) echocardiography short-axis images of the aorta were used to image the descending aorta immediately before and after interventions. Image analysis was performed with two-dimensional speckle tracking echocardiography and dedicated software. Delta GCS was calculated as: post-procedural GCS-pre-procedural GCS. Percentage delta GCS was calculated as: (delta GCS/pre-procedural GCS)×100.Eighty patients, 40 TAVR (median age 81 y/o, 40% female) and 40 SAVR (median 72 y/o, 30% female) were included. The post-procedure GCS was significantly higher than the pre-procedural GCS in the TAVR (median 10.7 [interquartile range IQR 4.5, 14.6] vs. 17.0 [IQR 6.1, 20.9], p=0.009) but not in the SAVR group (4.4 [IQR 3.3, 5.3] vs. 4.7 [IQR 3.9, 5.6], p=0.3). The delta GCS and the percentage delta GCS were both significantly higher in the TAVR versus SAVR group (2.8% [IQR 1.4, 6] vs. 0.15% [IQR-0.6, 1.5], p<0.001; and 28.8% [IQR 14.6%, 64.6%] vs. 4.4% [IQR-10.6%, 5.6%], p=0.006). Results were consistent after multivariable adjustment for key clinical and hemodynamic characteristics.After TAVR, there was a significantly larger increase in GCS in the distal aorta compared to SAVR. This may impact descending aortic remodeling and long-term risk of aortic events.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Rong, Lisa Q
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Zheng, William
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Martinez, Andrew
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Rahouma, Mohamme ...
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Devereux, Richar ...
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Kim, Jiwon
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show more...
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Osman, Bassam
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Palumbo, Maria C
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Redfors, Björn
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Girardi, Leonard ...
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Weinsaft, Jonath ...
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Gaudino, Mario
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Journal of cardi ...
- By the university
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University of Gothenburg