WFRF:(Di Pietro A)
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A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris).
- Appendino, G (author)
- Della Porta, C (author)
- Conseil, G (author)
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- Mercalli, E (author)
- Dumontet, C (author)
- Di Pietro, A (author)
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- (creator_code:org_t)
- 2002-12-12
- 2003
- English.
- In: Journal of Natural Products. - : American Chemical Society (ACS). - 0163-3864 .- 1520-6025. ; 66:1, s. 140-142
- Journal article (peer-reviewed)
Abstract
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- The macrocyclic lathyrane polyester Euphorbia factor L10 (1a) has been obtained from the seeds of the caper spurge (E. lathyris). The interaction of L10 (1a) and its acetyl derivative (1b) with P-glycoprotein, a multidrug transporter overexpressed in cancer cells and responsible for resistance to chemotherapy, was investigated. The results established lathyrane diterpenoids as a novel chemotype for P-glycoprotein inhibitors.
Subject headings
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
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- art (subject category)
- ref (subject category)
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- Appendino, G
- Della Porta, C
- Conseil, G
- Sterner, Olov
- Mercalli, E
- Dumontet, C
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- Di Pietro, A
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- NATURAL SCIENCES
- NATURAL SCIENCES
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- Journal of Natur ...
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- Lund University
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