Sökning: WFRF:(Dijs T.) >
Early-life antibiot...
Early-life antibiotic use and risk of attention-deficit hyperactivity disorder and autism spectrum disorder: results of a discordant twin study
-
- Slob, E. M. A. (författare)
- Department of Respiratory Medicine, Amsterdam University Medical Centers, DE Amsterdam, The Netherlands; Department of Paediatric Pulmonology, Amsterdam University Medical Centers, DE Amsterdam, The Netherlands
-
- Brew, B. K. (författare)
- Karolinska Institutet
-
- Vijverberg, S. J. H. (författare)
- Department of Respiratory Medicine, Amsterdam University Medical Centers, DE Amsterdam, The Netherlands; Department of Paediatric Pulmonology, Amsterdam University Medical Centers, DE Amsterdam, The Netherlands
-
visa fler...
-
- Dijs, T. (författare)
- Department of Respiratory Medicine, Amsterdam University Medical Centers, DE Amsterdam, The Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
-
- van Beijsterveldt, C. E. M. (författare)
- Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
-
- Koppelman, G. H. (författare)
- Department of Paediatric Pulmonology & Paediatric Allergology, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma & COPD (GRIAC), University Medical Center Groningen, Groningen, The Netherlands
-
- Bartels, M. (författare)
- Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
-
- Dolan, C. V. (författare)
- Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
-
- Larsson, Henrik, 1975- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
-
- Lundström, Sebastian (författare)
- Gothenburg University,Göteborgs universitet,Centrum för etik, juridik och mental hälsa,Institutionen för neurovetenskap och fysiologi,Centre for Ethics, Law, and Mental Health,Institute of Neuroscience and Physiology,Gillberg Neuropsychiatry Centre, Centre for Ethics Law and Mental Health (CELAM), Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden
-
- Lichtenstein, P. (författare)
- Karolinska Institutet
-
- Gong, T. (författare)
- Karolinska Institutet
-
- Maitland-van der Zee, A. H. (författare)
- Department of Respiratory Medicine, Amsterdam University Medical Centers, DE Amsterdam, The Netherlands; Department of Paediatric Pulmonology, Amsterdam University Medical Centers, DE Amsterdam, The Netherlands
-
- Kraneveld, A. D. (författare)
- Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands; Institute for Risk Assessment Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
-
- Almqvist, C. (författare)
- Karolinska Institutet
-
- Boomsma, D. I. (författare)
- Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
-
visa färre...
-
(creator_code:org_t)
- 2020-11-12
- 2021
- Engelska.
-
Ingår i: International journal of epidemiology. - : Oxford University Press (OUP). - 0300-5771 .- 1464-3685. ; 50:2, s. 475-484
- Relaterad länk:
-
https://academic.oup...
-
visa fler...
-
https://doi.org/10.1...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Development of the gut-brain axis in early life may be disturbed by antibiotic use. It has been hypothesized that this disturbance may contribute to development of neurodevelopmental disorders, including autism spectrum disorder and attention-deficit hyperactivity disorder. We aimed to assess the association between antibiotic use in early life and the risk of developing attention-deficit hyperactivity disorder or autism spectrum disorder, while controlling for shared genetic and environmental factors in a discordant twin design. Methods: We conducted a cohort study in twins (7-12 years; 25 781 twins) from the Netherlands Twin Register (NTR) and a replication study in the Childhood and Adolescent Twin Study in Sweden (CATSS; 7946 9-year-old twins). Antibiotic use was recorded before age 2 years. Attention-deficit hyperactivity disorder and autism spectrum disorder were parent-reported in the Netherlands Twin Register and register-based in the Childhood and Adolescent Twin Study in Sweden. Results: Early-life antibiotic use was associated with increased risk of attention-deficit hyperactivity disorder development [pooled odds ratio (OR) 1.10, 95% confidence interval (CI) 1.02-1.17] and autism spectrum disorder (pooled OR 1.15, 95% CI 1.06-1.25) in a case-control design. When restricting to monozygotic twin pairs discordant for the outcome, associations disappeared for both disorders in both cohorts (attention-deficit hyperactivity disorder OR 0.90, 95% CI 0.48-1.69 and OR 0.80, 95% CI 0.37-1.76, and autism spectrum disorder OR 0.66, 95% CI 0.38-1.16 and OR 0.29, 95% CI 0.02-4.50, respectively). Conclusions: Our findings suggest that the association between early-life antibiotic use and risk of attention-deficit hyperactivity and autism spectrum disorder may be confounded by shared familial environment and genetics.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- ASD
- ADHD
- antibiotics
- early life
- children
- discordant twin design
- gut-brain axis
- child-behavior checklist
- chain fatty-acids
- prevalence
- registry
- microbiota
- delivery
- traits
- family
- Public
- Environmental & Occupational Health
- ADHD
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Slob, E. M. A.
-
Brew, B. K.
-
Vijverberg, S. J ...
-
Dijs, T.
-
van Beijsterveld ...
-
Koppelman, G. H.
-
visa fler...
-
Bartels, M.
-
Dolan, C. V.
-
Larsson, Henrik, ...
-
Lundström, Sebas ...
-
Lichtenstein, P.
-
Gong, T.
-
Maitland-van der ...
-
Kraneveld, A. D.
-
Almqvist, C.
-
Boomsma, D. I.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Psykiatri
- Artiklar i publikationen
-
International jo ...
- Av lärosätet
-
Göteborgs universitet
-
Örebro universitet
-
Karolinska Institutet