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Disseminated tumour...
Disseminated tumour cells from the bone marrow of early breast cancer patients : Results from an international pooled analysis
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- Hartkopf, Andreas D. (författare)
- University of Tübingen
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- Brucker, Sara Y. (författare)
- University of Tübingen
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- Taran, Florin Andrei (författare)
- University of Tübingen,University Medical Center Freiburg
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- Harbeck, Nadia (författare)
- Ludwig-Maximilian University of Munich
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- von Au, Alexandra (författare)
- University Hospital Heidelberg
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- Naume, Bjørn (författare)
- Oslo university hospital
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- Pierga, Jean Yves (författare)
- Curie Institute, Paris
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- Hoffmann, Oliver (författare)
- University Hospital Essen
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- Beckmann, Matthias W. (författare)
- University Hospital Erlangen
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- Rydén, Lisa (författare)
- Lund University,Lunds universitet,Bröstcancerkirurgi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breast Cancer Surgery,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Fehm, Tanja (författare)
- Heinrich Heine University Düsseldorf
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- Aft, Rebecca (författare)
- Washington University in St. Louis
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- Solà, Montserrat (författare)
- Hospital Universitari Germans Trias i Pujol
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- Walter, Vincent (författare)
- University of Tübingen
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- Rack, Brigitte (författare)
- University Hospital of Ulm
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- Schuetz, Florian (författare)
- University Hospital Heidelberg
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- Borgen, Elin (författare)
- Oslo university hospital
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- Ta, Minh Hanh (författare)
- Curie Institute, Paris
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- Bittner, Ann Kathrin (författare)
- University Hospital Essen
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- Fasching, Peter A. (författare)
- University Hospital Erlangen
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- Fernö, Mårten (författare)
- Lund University,Lunds universitet,Individuell Bröstcancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Personalized Breast Cancer Treatment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Krawczyk, Natalia (författare)
- Heinrich Heine University Düsseldorf
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- Weilbaecher, Katherine (författare)
- Washington University in St. Louis
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- Margelí, Mireia (författare)
- Institute for Health Science Research Germans Trias i Pujol (IGTP)
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- Hahn, Markus (författare)
- University of Tübingen
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- Jueckstock, Julia (författare)
- Ludwig-Maximilian University of Munich
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- Domschke, Christoph (författare)
- University Hospital Heidelberg
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- Bidard, Francois Clement (författare)
- Curie Institute, Paris
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- Kasimir-Bauer, Sabine (författare)
- University Hospital Essen
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- Schoenfisch, Birgitt (författare)
- University of Tübingen
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- Kurt, Ayse G. (författare)
- Ludwig-Maximilian University of Munich
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- Wallwiener, Markus (författare)
- University Hospital Heidelberg
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- Gebauer, Gerhard (författare)
- Asklepios Kliniken Hamburg GmbH
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- Klein, Christoph A. (författare)
- University of Regensburg
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- Wallwiener, Diethelm (författare)
- University of Tübingen
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- Janni, Wolfgang (författare)
- University Hospital of Ulm
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- Pantel, Klaus (författare)
- University Medical Center Hamburg-Eppendorf
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- Engelska 10 s.
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Ingår i: European Journal of Cancer. - : Elsevier BV. - 0959-8049. ; 154, s. 128-137
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Purpose: Presence of disseminated tumour cells (DTCs) in the bone marrow (BM) has been described as a surrogate of residual disease in patients with early breast cancer (EBC). PADDY (Pooled Analysis of DTC Detection in Early Breast Cancer) is a large international analysis of pooled data that aimed to assess the prognostic impact of DTCs in patients with EBC. Experimental design: Individual patient data were collected from 11 centres. Patients with EBC and available follow-up data in whom BM sampling was performed at the time of primary diagnosis before receiving any anticancer treatment were eligible. DTCs were identified by antibody staining against epithelial cytokeratins. Multivariate Cox regression was used to compare the survival of DTC-positive versus DTC-negative patients. Results: In total, 10,307 patients were included. Of these, 2814 (27.3%) were DTC-positive. DTC detection was associated with higher tumour grade, larger tumour size, nodal positivity, oestrogen receptor and progesterone receptor negativity, and HER2 positivity (all p < 0.001). Multivariate analyses showed that DTC detection was an independent prognostic marker for overall survival, disease-free survival and distant disease-free survival with hazard ratios (HR) and 95% confidence intervals (CI) of 1.23 (95% CI: 1.06–1.43, p = 0.006), 1.30 (95% CI: 1.12–1.52, p < 0.001) and 1.30 (95% CI: 1.08–1.56, p = 0.006), respectively. There was no association between locoregional relapse-free survival and DTC detection (HR 1.21; 95% CI 0.68–2.16; p = 0.512). Conclusions: DTCs in the BM represent an independent prognostic marker in patients with EBC. The heterogeneous metastasis-initiating potential of DTCs is consistent with the concept of cancer dormancy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Bone marrow
- Disseminated tumour cells
- Early breast cancer
- Micrometastases
- Prognosis
- Tumour staging
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Hartkopf, Andrea ...
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Brucker, Sara Y.
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Taran, Florin An ...
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Harbeck, Nadia
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von Au, Alexandr ...
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Naume, Bjørn
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visa fler...
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Pierga, Jean Yve ...
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Hoffmann, Oliver
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Beckmann, Matthi ...
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Rydén, Lisa
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Fehm, Tanja
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Aft, Rebecca
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Solà, Montserrat
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Walter, Vincent
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Rack, Brigitte
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Schuetz, Florian
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Borgen, Elin
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Ta, Minh Hanh
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Bittner, Ann Kat ...
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Fasching, Peter ...
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Fernö, Mårten
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Krawczyk, Natali ...
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Weilbaecher, Kat ...
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Margelí, Mireia
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Hahn, Markus
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Jueckstock, Juli ...
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Domschke, Christ ...
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Bidard, Francois ...
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Kasimir-Bauer, S ...
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Schoenfisch, Bir ...
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Kurt, Ayse G.
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Wallwiener, Mark ...
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Gebauer, Gerhard
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Klein, Christoph ...
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Wallwiener, Diet ...
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Janni, Wolfgang
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Pantel, Klaus
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