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Sökning: WFRF:(Duarte Fernanda) > (2020) > Transient gain of f...

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FältnamnIndikatorerMetadata
00004640naa a2200565 4500
001oai:lup.lub.lu.se:e9b477ee-f150-47bf-80aa-e6e11be1687a
003SwePub
008200611s2020 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/e9b477ee-f150-47bf-80aa-e6e11be1687a2 URI
0247 a https://doi.org/10.1016/j.brainresbull.2020.05.0042 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Pedro, Joana Reisu University of Coimbra4 aut
2451 0a Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes
264 1b Elsevier BV,c 2020
300 a 10 s.
520 a Here we aimed to unify some previous controversial reports on changes in both cannabinoid CB1 receptor (CB1R) expression and glucose metabolism in the forebrain of rodent models of diabetes. We determined how glucose metabolism and its modulation by CB1R ligands evolve in the frontal cortex of young adult male Wistar rats, in the first 8 weeks of streptozotocin-induced type-1 diabetes (T1D). We report that frontocortical CB1R protein density was biphasically altered in the first month of T1D, which was accompanied with a reduction of resting glucose uptake ex vivo in acute frontocortical slices that was normalized after eight weeks in T1D. This early reduction of glucose uptake in slices was also restored by ex vivo treatment with both the non-selective CB1R agonists, WIN55212−2 (500 nM) and the CB1R-selective agonist, ACEA (3 μM) while it was exacerbated by the CB1R-selective antagonist, O-2050 (500 nM). These results suggest a gain-of-function for the cerebrocortical CB1Rs in the control of glucose uptake in diabetes. Although insulin and IGF-1 receptor protein densities remained unaffected, phosphorylated GSKα and GSKβ levels showed different profiles 2 and 8 weeks after T1D induction in the frontal cortex. Altogether, the biphasic response in frontocortical CB1R density within a month after T1D induction resolves previous controversial reports on forebrain CB1R levels in T1D rodent models. Furthermore, this study also hints that cannabinoids may be useful to alleviate impaired glucoregulation in the diabetic cortex.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a Cannabinoid CBreceptor
653 a Cerebral glucose metabolism
653 a Frontal cortex
653 a Goto-Kakizaki rat
653 a type-1 diabetes
653 a Wistar rat
7001 a Moura, Liane I.F.u University of Coimbra4 aut
7001 a Valério-Fernandes, Ângelau University of Coimbra4 aut
7001 a Baptista, Filipa I.u University of Coimbra4 aut
7001 a Gaspar, Joana M.u University of Coimbra4 aut
7001 a Pinheiro, Bárbara S.u University of Coimbra4 aut
7001 a Lemos, Cristinau University of Coimbra4 aut
7001 a Kaufmann, Fernanda Neutzlingu University of Coimbra4 aut
7001 a Morgado, Carlau University of Porto4 aut
7001 a Silva-Santos, Carla S.dau University of Coimbra4 aut
7001 a Tavares, Isaurau Institute for Molecular and Cell Biology,University of Porto4 aut
7001 a Ferreira, Samira G.u University of Coimbra4 aut
7001 a Carvalho, Eugéniau University of Coimbra,University of Arkansas for Medical Sciences4 aut
7001 a Ambrósio, António F.u University of Coimbra4 aut
7001 a Cunha, Rodrigo A.u University of Coimbra4 aut
7001 a Duarte, João M.N.u Lund University,Lunds universitet,Diabetes och hjärnans funktion,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Diabetes and Brain Function,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine4 aut0 (Swepub:lu)jo2654du
7001 a Köfalvi, Attilau University of Coimbra4 aut
7102 a University of Coimbrab University of Porto4 org
7730 t Brain Research Bulletind : Elsevier BVg 161, s. 106-115q 161<106-115x 0361-9230
8564 u http://dx.doi.org/10.1016/j.brainresbull.2020.05.004y FULLTEXT
8564 u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281444
8564 8u https://lup.lub.lu.se/record/e9b477ee-f150-47bf-80aa-e6e11be1687a
8564 8u https://doi.org/10.1016/j.brainresbull.2020.05.004

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