WFRF:(Duchardt Ferner E)
Sökning: WFRF:(Duchardt Ferner E) > (2020) > Secondary structure...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04517naa a2201009 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:145646070 | |
| 003 | SwePub | |
| 008 | 240701s2020 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1456460702 URI |
| 024 | 7 | a https://doi.org/10.1093/nar/gkaa10132 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Wacker, A4 aut |
| 245 | 1 0 | a Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy |
| 264 | c 2020-11-10 | |
| 264 | 1 | b Oxford University Press (OUP),c 2020 |
| 520 | a The current pandemic situation caused by the Betacoronavirus SARS-CoV-2 (SCoV2) highlights the need for coordinated research to combat COVID-19. A particularly important aspect is the development of medication. In addition to viral proteins, structured RNA elements represent a potent alternative as drug targets. The search for drugs that target RNA requires their high-resolution structural characterization. Using nuclear magnetic resonance (NMR) spectroscopy, a worldwide consortium of NMR researchers aims to characterize potential RNA drug targets of SCoV2. Here, we report the characterization of 15 conserved RNA elements located at the 5′ end, the ribosomal frameshift segment and the 3′-untranslated region (3′-UTR) of the SCoV2 genome, their large-scale production and NMR-based secondary structure determination. The NMR data are corroborated with secondary structure probing by DMS footprinting experiments. The close agreement of NMR secondary structure determination of isolated RNA elements with DMS footprinting and NMR performed on larger RNA regions shows that the secondary structure elements fold independently. The NMR data reported here provide the basis for NMR investigations of RNA function, RNA interactions with viral and host proteins and screening campaigns to identify potential RNA binders for pharmaceutical intervention. | |
| 700 | 1 | a Weigand, JE4 aut |
| 700 | 1 | a Akabayov, SR4 aut |
| 700 | 1 | a Altincekic, N4 aut |
| 700 | 1 | a Bains, JK4 aut |
| 700 | 1 | a Banijamali, E4 aut |
| 700 | 1 | a Binas, O4 aut |
| 700 | 1 | a Castillo-Martinez, J4 aut |
| 700 | 1 | a Cetiner, E4 aut |
| 700 | 1 | a Ceylan, B4 aut |
| 700 | 1 | a Chiu, LY4 aut |
| 700 | 1 | a Davila-Calderon, J4 aut |
| 700 | 1 | a Dhamotharan, K4 aut |
| 700 | 1 | a Duchardt-Ferner, E4 aut |
| 700 | 1 | a Ferner, J4 aut |
| 700 | 1 | a Frydman, L4 aut |
| 700 | 1 | a Furtig, B4 aut |
| 700 | 1 | a Gallego, J4 aut |
| 700 | 1 | a Grun, JT4 aut |
| 700 | 1 | a Hacker, C4 aut |
| 700 | 1 | a Haddad, C4 aut |
| 700 | 1 | a Hahnke, M4 aut |
| 700 | 1 | a Hengesbach, M4 aut |
| 700 | 1 | a Hiller, F4 aut |
| 700 | 1 | a Hohmann, KF4 aut |
| 700 | 1 | a Hymon, D4 aut |
| 700 | 1 | a de Jesus, V4 aut |
| 700 | 1 | a Jonker, H4 aut |
| 700 | 1 | a Keller, H4 aut |
| 700 | 1 | a Knezic, B4 aut |
| 700 | 1 | a Landgraf, T4 aut |
| 700 | 1 | a Lohr, F4 aut |
| 700 | 1 | a Luo, L4 aut |
| 700 | 1 | a Mertinkus, KR4 aut |
| 700 | 1 | a Muhs, C4 aut |
| 700 | 1 | a Novakovic, M4 aut |
| 700 | 1 | a Oxenfarth, A4 aut |
| 700 | 1 | a Palomino-Schatzlein, M4 aut |
| 700 | 1 | a Petzold, Ku Karolinska Institutet4 aut |
| 700 | 1 | a Peter, SA4 aut |
| 700 | 1 | a Pyper, DJ4 aut |
| 700 | 1 | a Qureshi, NS4 aut |
| 700 | 1 | a Riad, M4 aut |
| 700 | 1 | a Richter, C4 aut |
| 700 | 1 | a Saxena, K4 aut |
| 700 | 1 | a Schamber, T4 aut |
| 700 | 1 | a Scherf, T4 aut |
| 700 | 1 | a Schlagnitweit, J4 aut |
| 700 | 1 | a Schlundt, A4 aut |
| 700 | 1 | a Schnieders, R4 aut |
| 700 | 1 | a Schwalbe, H4 aut |
| 700 | 1 | a Simba-Lahuasi, A4 aut |
| 700 | 1 | a Sreeramulu, S4 aut |
| 700 | 1 | a Stirnal, E4 aut |
| 700 | 1 | a Sudakov, A4 aut |
| 700 | 1 | a Tants, JN4 aut |
| 700 | 1 | a Tolbert, BS4 aut |
| 700 | 1 | a Vogele, J4 aut |
| 700 | 1 | a Weiss, L4 aut |
| 700 | 1 | a Wirmer-Bartoschek, J4 aut |
| 700 | 1 | a Martin, MAW4 aut |
| 700 | 1 | a Wohnert, J4 aut |
| 700 | 1 | a Zetzsche, H4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Nucleic acids researchd : Oxford University Press (OUP)g 48:22, s. 12415-12435q 48:22<12415-12435x 1362-4962x 0305-1048 |
| 856 | 4 | u https://academic.oup.com/nar/article-pdf/48/22/12415/38817308/gkaa1013.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:145646070 |
| 856 | 4 8 | u https://doi.org/10.1093/nar/gkaa1013 |
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- Wacker, A
- Weigand, JE
- Akabayov, SR
- Altincekic, N
- Bains, JK
- Banijamali, E
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- Binas, O
- Castillo-Martine ...
- Cetiner, E
- Ceylan, B
- Chiu, LY
- Davila-Calderon, ...
- Dhamotharan, K
- Duchardt-Ferner, ...
- Ferner, J
- Frydman, L
- Furtig, B
- Gallego, J
- Grun, JT
- Hacker, C
- Haddad, C
- Hahnke, M
- Hengesbach, M
- Hiller, F
- Hohmann, KF
- Hymon, D
- de Jesus, V
- Jonker, H
- Keller, H
- Knezic, B
- Landgraf, T
- Lohr, F
- Luo, L
- Mertinkus, KR
- Muhs, C
- Novakovic, M
- Oxenfarth, A
- Palomino-Schatzl ...
- Petzold, K
- Peter, SA
- Pyper, DJ
- Qureshi, NS
- Riad, M
- Richter, C
- Saxena, K
- Schamber, T
- Scherf, T
- Schlagnitweit, J
- Schlundt, A
- Schnieders, R
- Schwalbe, H
- Simba-Lahuasi, A
- Sreeramulu, S
- Stirnal, E
- Sudakov, A
- Tants, JN
- Tolbert, BS
- Vogele, J
- Weiss, L
- Wirmer-Bartosche ...
- Martin, MAW
- Wohnert, J
- Zetzsche, H
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