Search: WFRF:(Eastwood Glenn M.)
> (2020) >
Protocol for outcom...
Protocol for outcome reporting and follow-up in the Targeted Hypothermia versus Targeted Normothermia after Out-of-Hospital Cardiac Arrest trial (TTM2)
-
- Lilja, Gisela (author)
- Lund University,Lunds universitet,Brain Injury After Cardiac Arrest,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
-
- Nielsen, Niklas (author)
- Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Center for cardiac arrest,Lund University Research Groups,Helsingborg Hospital
-
- Ullén, Susann (author)
- Skåne University Hospital
-
show more...
-
- Blennow Nordstrom, Erik (author)
- Lund University,Lunds universitet,Brain Injury After Cardiac Arrest,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
-
- Dankiewicz, Josef (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
-
- Friberg, Hans (author)
- Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Center for cardiac arrest,Lund University Research Groups,Skåne University Hospital
-
- Heimburg, Katarina (author)
- Lund University,Lunds universitet,Brain Injury After Cardiac Arrest,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
-
- Jakobsen, Janus Christian (author)
- University of Southern Denmark,Holbæk Hospital
-
- Levin, Helena (author)
- Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Center for cardiac arrest,Lund University Research Groups,Skåne University Hospital
-
- Callaway, Clifton (author)
- University of Pittsburgh
-
- Cariou, Alain (author)
- Cochin Hospital,Paris Descartes University
-
- Eastwood, Glenn M. (author)
- Monash University
-
- Helbok, Raimund (author)
- Medical University of Innsbruck
-
- Hovdenes, Jan (author)
- Oslo university hospital
-
- Kirkegaard, Hans (author)
- Aarhus University Hospital,Aarhus University
-
- Leithner, Christoph (author)
- Charité - University Medicine Berlin
-
- Morgan, Matt P.G. (author)
- University Hospital of Wales
-
- Nordberg, Per (author)
- Karolinska Institutet,Karolinska Institute
-
- Oddo, Mauro (author)
- University of Lausanne,Lausanne University Hospital
-
- Pelosi, Paolo (author)
- University of Genoa,Ospedale Policlinico San Martino
-
- Rylander, Christian, 1960 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård,Institute of Clinical Sciences, Department of Anesthesiology and Intensive care
-
- Saxena, Manoj (author)
- Bankstown-Lidcombe Hospital,University of New South Wales
-
- Taccone, Fabio Silvio (author)
- Université Libre de Bruxelles (ULB),Hospital Erasme
-
- Siranec, Michal (author)
- General University Hospital in Prague,Charles University in Prague
-
- Wise, Matthew P. (author)
- University Hospital of Wales
-
- Young, Paul J. (author)
- Medical Research Institute of New Zealand
-
- Cronberg, Tobias (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Brain Injury After Cardiac Arrest,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English 9 s.
-
In: Resuscitation. - : Elsevier BV. - 0300-9572 .- 1873-1570. ; 150, s. 104-112
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
http://www.resuscita...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
http://kipublication...
-
https://gup.ub.gu.se...
-
show less...
Abstract
Subject headings
Close
- Aims: The TTM2-trial is a multi-centre randomised clinical trial where targeted temperature management (TTM) at 33 °C will be compared with normothermia and early treatment of fever (≥37.8 °C) after Out-of-Hospital Cardiac Arrest (OHCA). This paper presents the design and rationale of the TTM2-trial follow-up, where information on secondary and exploratory outcomes will be collected. We also present the explorative outcome analyses which will focus on neurocognitive function and societal participation in OHCA-survivors. Methods: Blinded outcome-assessors will perform follow-up at 30-days after the OHCA with a telephone interview, including the modified Rankin Scale (mRS) and the Glasgow Outcome Scale Extended (GOSE). Face-to-face meetings will be performed at 6 and 24-months, and include reports on outcome from several sources of information: clinician-reported: mRS, GOSE; patient-reported: EuroQol-5 Dimensions-5 Level responses version (EQ-5D-5L), Life satisfaction, Two Simple Questions; observer-reported: Informant Questionnaire on Cognitive Decline in the Elderly-Cardiac Arrest version (IQCODE-CA) and neurocognitive performance measures: Montreal Cognitive Assessment, (MoCA), Symbol Digit Modalities Test (SDMT). Exploratory analyses will be performed with an emphasis on brain injury in the survivors, where the two intervention groups will be compared for potential differences in neuro-cognitive function (MoCA, SDMT) and societal participation (GOSE). Strategies to increase inter-rater reliability and decrease missing data are described. Discussion: The TTM2-trial follow-up is a pragmatic yet detailed pre-planned and standardised assessment of patient's outcome designed to ensure data-quality, decrease missing data and provide optimal conditions to investigate clinically relevant effects of TTM, including OHCA-survivors’ neurocognitive function and societal participation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Keyword
- Cardiac arrest
- Cognitive function
- Patient Reported Outcome Measures
- Quality of life
- Treatment outcome
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Lilja, Gisela
-
Nielsen, Niklas
-
Ullén, Susann
-
Blennow Nordstro ...
-
Dankiewicz, Jose ...
-
Friberg, Hans
-
show more...
-
Heimburg, Katari ...
-
Jakobsen, Janus ...
-
Levin, Helena
-
Callaway, Clifto ...
-
Cariou, Alain
-
Eastwood, Glenn ...
-
Helbok, Raimund
-
Hovdenes, Jan
-
Kirkegaard, Hans
-
Leithner, Christ ...
-
Morgan, Matt P.G ...
-
Nordberg, Per
-
Oddo, Mauro
-
Pelosi, Paolo
-
Rylander, Christ ...
-
Saxena, Manoj
-
Taccone, Fabio S ...
-
Siranec, Michal
-
Wise, Matthew P.
-
Young, Paul J.
-
Cronberg, Tobias
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Anesthesiology a ...
- Articles in the publication
-
Resuscitation
- By the university
-
Lund University
-
Karolinska Institutet
-
University of Gothenburg