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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04204naa a2200409 4500 | |
| 001 | oai:DiVA.org:uu-269644 | |
| 003 | SwePub | |
| 008 | 151217s2015 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:132710328 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2696442 URI |
| 024 | 7 | a https://doi.org/10.1016/j.redox.2015.05.0062 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1327103282 URI |
| 040 | a (SwePub)uud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Lourenço Dos Santos, Sofiau Sorbonne Universités, UPMC Univ Paris 06, UMR 8256, Biological Adaptation and Ageing-IBPS, Paris, France4 aut |
| 245 | 1 0 | a Oxidative proteome alterations during skeletal muscle ageing |
| 264 | 1 | b Elsevier BV,c 2015 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Sarcopenia corresponds to the degenerative loss of skeletal muscle mass, quality, and strength associated with ageing and leads to a progressive impairment of mobility and quality of life. However, the cellular and molecular mechanisms involved in this process are not completely understood. A hallmark of cellular and tissular ageing is the accumulation of oxidatively modified (carbonylated) proteins, leading to a decreased quality of the cellular proteome that could directly impact on normal cellular functions. Although increased oxidative stress has been reported during skeletal muscle ageing, the oxidized protein targets, also referred as to the 'oxi-proteome' or 'carbonylome', have not been characterized yet. To better understand the mechanisms by which these damaged proteins build up and potentially affect muscle function, proteins targeted by these modifications have been identified in human rectus abdominis muscle obtained from young and old healthy donors using a bi-dimensional gel electrophoresis-based proteomic approach coupled with immunodetection of carbonylated proteins. Among evidenced protein spots, 17 were found as increased carbonylated in biopsies from old donors comparing to young counterparts. These proteins are involved in key cellular functions such as cellular morphology and transport, muscle contraction and energy metabolism. Importantly, impairment of these pathways has been described in skeletal muscle during ageing. Functional decline of these proteins due to irreversible oxidation may therefore impact directly on the above-mentioned pathways, hence contributing to the generation of the sarcopenic phenotype. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng |
| 700 | 1 | a Baraibar, Martin Au Sorbonne Universités, UPMC Univ Paris 06, UMR 8256, Biological Adaptation and Ageing-IBPS, Paris, France4 aut |
| 700 | 1 | a Lundberg, Staffan,d 1956-u Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnneurologisk forskning/Ahlsten4 aut0 (Swepub:uu)staflund |
| 700 | 1 | a Eeg-Olofsson, Orvar,d 1932-u Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnneurologisk forskning/Ahlsten4 aut0 (Swepub:uu)orvareo |
| 700 | 1 | a Larsson, Larsu Karolinska Institutet4 aut |
| 700 | 1 | a Friguet, Bertrandu Sorbonne Universités, UPMC Univ Paris 06, UMR 8256, Biological Adaptation and Ageing-IBPS, Paris, France4 aut |
| 710 | 2 | a Sorbonne Universités, UPMC Univ Paris 06, UMR 8256, Biological Adaptation and Ageing-IBPS, Paris, Franceb Institutionen för kvinnors och barns hälsa4 org |
| 773 | 0 | t Redox Biologyd : Elsevier BVg 5, s. 267-274q 5<267-274x 2213-2317 |
| 856 | 4 | u https://doi.org/10.1016/j.redox.2015.05.006y Fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:883569/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://doi.org/10.1016/j.redox.2015.05.006 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-269644 |
| 856 | 4 8 | u https://doi.org/10.1016/j.redox.2015.05.006 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:132710328 |
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