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WFRF:(Eendebak Robert J A H)
 

Sökning: WFRF:(Eendebak Robert J A H) > The androgen recept...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004466naa a2200541 4500
001oai:lup.lub.lu.se:9ed84d39-a171-4364-836e-cb92b67c02b7
003SwePub
008161219s2016 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/9ed84d39-a171-4364-836e-cb92b67c02b72 URI
0247 a https://doi.org/10.1530/EJE-16-04472 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Eendebak, Robert J A Hu University of Manchester4 aut
2451 0a The androgen receptor gene CAG repeat in relation to 4-year changes in androgen-sensitive endpoints in community-dwelling older European men
264 1c 2016
300 a 11 s.
520 a Context: The androgen receptor (AR) gene exon 1 CAG repeat length has been proposed to be a determinant of between-individual variations in androgen action in target tissues, which might regulate phenotypic differences of human ageing. However, findings on its phenotypic effects are inconclusive. Objective: To assess whether the AR CAG repeat length is associated with longitudinal changes in endpoints that are influenced by testosterone (T) levels in middle-Aged and elderly European men. Design: Multinational European observational prospective cohort study. Participants: A total of 1887 men (mean ± s.d. age: 63 ± 11 years; median follow up: 4.3 years) from centres of eight European countries comprised the analysis sample after exclusion of those with diagnosed diseases of the hypothalamic-pituitary-testicular (HPT) axis. Main outcome measures: Longitudinal associations between the AR CAG repeat and changes in androgen-sensitive endpoints (ASEs) and medical conditions were assessed using regression analysis adjusting for age and centre. The AR CAG repeat length was treated as both a continuous and a categorical (6-20; 21-23; 24-39 repeats) predictor. Additional analysis investigated whether results were independent of baseline T or oestradiol (E2) levels. Results: The AR CAG repeat, when used as a continuous or a categorical predictor, was not associated with longitudinal changes in ASEs or medical conditions after adjustments. These results were independent of T and E2 levels.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Huhtaniemi, Ilpo T.u Imperial College London4 aut
7001 a Pye, Stephen R.u University of Manchester4 aut
7001 a Ahern, Tomasu University of Manchester4 aut
7001 a W O'Neill, Terenceu University of Manchester4 aut
7001 a Bartfai, Györgyu University of Szeged4 aut
7001 a Casanueva, Felipe F.u University of Santiago de Compostela4 aut
7001 a Maggi, Mariou University of Florence4 aut
7001 a Forti, Gianniu University of Florence4 aut
7001 a Alston, Robert D.u University of Manchester4 aut
7001 a Giwercman, Aleksanderu Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)kir-agi
7001 a Han, Thang S.u University College London4 aut
7001 a Kula, Krzysztofu Medical University of Lodz4 aut
7001 a Lean, Michael E Ju University of Glasgow4 aut
7001 a Punab, Margusu University of Tartu4 aut
7001 a Pendleton, Neilu University of Manchester4 aut
7001 a Keevil, Brian G.u University Hospital of South Manchester NHS Foundation Trust4 aut
7001 a Vanderschueren, Dirku Catholic University of Leuven4 aut
7001 a Rutter, Martin K.u Manchester University NHS Foundation Trust,University of Manchester4 aut
7001 a Tampubolon, Gindou University of Manchester4 aut
7001 a Goodacre, Roystonu University of Manchester4 aut
7001 a Wu, Frederick C Wu University of Manchester4 aut
7102 a University of Manchesterb Imperial College London4 org
7730 t European Journal of Endocrinologyg 175:6, s. 583-593q 175:6<583-593x 0804-4643
8564 u http://dx.doi.org/10.1530/EJE-16-0447y FULLTEXT
8564 8u https://lup.lub.lu.se/record/9ed84d39-a171-4364-836e-cb92b67c02b7
8564 8u https://doi.org/10.1530/EJE-16-0447

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