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Sökning: WFRF:(Ekblad Laura L.) > Lötjönen Jyrki > Midlife Insulin Res...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004567naa a2200625 4500
001oai:DiVA.org:umu-166832
003SwePub
008200103s2019 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:142459628
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1668322 URI
0247 a https://doi.org/10.3233/JAD-1906912 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1424596282 URI
040 a (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Toppala, Sini4 aut
2451 0a Midlife Insulin Resistance as a Predictor for Late-Life Cognitive Function and Cerebrovascular Lesions
264 1b IOS Press,c 2019
338 a electronic2 rdacarrier
520 a Background: Type 2 diabetes (T2DM) increases the risk for Alzheimer’s disease (AD) but not for AD neuropathology. The association between T2DM and AD is assumed to be mediated through vascular mechanisms. However, insulin resistance (IR), the hallmark of T2DM, has been shown to associate with AD neuropathology and cognitive decline.Objective: To evaluate if midlife IR predicts late-life cognitive performance and cerebrovascular lesions (white matter hyperintensities and total vascular burden), and whether cerebrovascular lesions and brain amyloid load are associated with cognitive functioning.Methods: This exposure-to-control follow-up study examined 60 volunteers without dementia (mean age 70.9 years) with neurocognitive testing, brain 3T-MRI and amyloid-PET imaging. The volunteers were recruited from the Finnish Health 2000 survey (n = 6062) to attend follow-up examinations in 2014–2016 according to their insulin sensitivity in 2000 and their APOE genotype. The exposure group (n = 30) had IR in 2000 and the 30 controls had normal insulin sensitivity. There were 15 APOE ɛ4 carriers per group. Statistical analyses were performed with multivariable linear models.Results: At follow-up the IR+group performed worse on executive functions (p = 0.02) and processing speed (p = 0.007) than the IR- group. The groups did not differ in cerebrovascular lesions. No associations were found between cerebrovascular lesions and neurocognitive test scores. Brain amyloid deposition associated with slower processing speed.Conclusion: Midlife IR predicted poorer executive functions and slower processing speed, but not cerebrovascular lesions. Brain amyloid deposition was associated with slower processing speed. The association between midlife IR and late-life cognition might not be mediated through cerebrovascular lesions measured here.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653 a Alzheimer's disease
653 a amyloid
653 a APOE
653 a C-11-PIB
653 a cerebrovascular lesions
653 a cognition
653 a follow-up study
653 a insulin resistance
653 a magnetic resonance imaging
653 a PET scan
7001 a Ekblad, Laura L.4 aut
7001 a Lötjönen, Jyrki4 aut
7001 a Helin, Semi4 aut
7001 a Hurme, Saija4 aut
7001 a Johansson, Jarkkou Umeå universitet,Diagnostisk radiologi,Turku PET Centre, University of Turku, Finland4 aut0 (Swepub:umu)jajo0061
7001 a Jula, Antti4 aut
7001 a Karrasch, Mira4 aut
7001 a Koikkalainen, Juha4 aut
7001 a Laine, Hanna4 aut
7001 a Parkkola, Riitta4 aut
7001 a Viitanen, Mattiu Karolinska Institutet4 aut
7001 a Rinne, Juha O.4 aut
7102 a Umeå universitetb Diagnostisk radiologi4 org
7730 t Journal of Alzheimer's Diseased : IOS Pressg 72:1, s. 215-228q 72:1<215-228x 1387-2877x 1875-8908
8564 u https://doi.org/10.3233/JAD-190691y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1382440/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-166832
8564 8u https://doi.org/10.3233/JAD-190691
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:142459628

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