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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006673naa a2200961 4500
001oai:lup.lub.lu.se:1ba55a46-45cb-448d-aa03-d8467a51e521
003SwePub
008171030s2017 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/1ba55a46-45cb-448d-aa03-d8467a51e5212 URI
0247 a https://doi.org/10.1136/annrheumdis-2017-2114482 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Elhai, Murielu Paris Descartes University4 aut
2451 0a Mapping and predicting mortality from systemic sclerosis
264 c 2017-08-23
264 1b BMJ,c 2017
300 a 9 s.
520 a Objectives To determine the causes of death and risk factors in systemic sclerosis (SSc). Methods Between 2000 and 2011, we examined the death certificates of all French patients with SSc to determine causes of death. Then we examined causes of death and developed a score associated with all-cause mortality from the international European Scleroderma Trials and Research (EUSTAR) database. Candidate prognostic factors were tested by Cox proportional hazards regression model by single variable analysis, followed by a multiple variable model stratified by centres. The bootstrapping technique was used for internal validation. Results We identified 2719 French certificates of deaths related to SSc, mainly from cardiac (31%) and respiratory (18%) causes, and an increase in SSc-specific mortality over time. Over a median follow-up of 2.3 years, 1072 (9.6%) of 11 193 patients from the EUSTAR sample died, from cardiac disease in 27% and respiratory causes in 17%. By multiple variable analysis, a risk score was developed, which accurately predicted the 3-year mortality, with an area under the curve of 0.82. The 3-year survival of patients in the upper quartile was 53%, in contrast with 98% in the first quartile. Conclusion Combining two complementary and detailed databases enabled the collection of an unprecedented 3700 deaths, revealing the major contribution of the cardiopulmonary system to SSc mortality. We also developed a robust score to risk-stratify these patients and estimate their 3-year survival. With the emergence of new therapies, these important observations should help caregivers plan and refine the monitoring and management to prolong these patients' survival.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a cardiovascular disease
653 a epidemiology
653 a pulmonary fibrosis
653 a systemic sclerosis
7001 a Meune, Christopheu Sorbonne Paris Nord University4 aut
7001 a Boubaya, Marouaneu Sorbonne Paris Nord University4 aut
7001 a Avouac, Jérômeu Paris Descartes University4 aut
7001 a Hachulla, Ericu University of Lille4 aut
7001 a Balbir-Gurman, Alexandrau Technion - Israel Institute of Technology4 aut
7001 a Riemekasten, Gabrielau University of Lübeck4 aut
7001 a Airò, Paolou Spedali Civili Di Brescia4 aut
7001 a Joven, Beatrizu 12 de Octubre University Hospital4 aut
7001 a Vettori, Serenau University of Campania Luigi Vanvitelli4 aut
7001 a Cozzi, Francou University of Padova4 aut
7001 a Ullman, Susanneu Copenhagen University Hospital4 aut
7001 a Czirják, Lászlóu University of Pécs4 aut
7001 a Tikly, Mohammed4 aut
7001 a Müller-Ladner, Ulfu Justus Liebig University Giessen4 aut
7001 a Caramaschi, Paolau University of Verona4 aut
7001 a Distler, Oliveru University Hospital of Zurich4 aut
7001 a Iannone, Florenzou University of Bari Aldo Moro4 aut
7001 a Ananieva, Lidia P.4 aut
7001 a Hesselstrand, Rogeru Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-rhe
7001 a Becvar, Radimu Charles University in Prague4 aut
7001 a Gabrielli, Armandou Marche Polytechnic University4 aut
7001 a Damjanov, Nemanjau University of Belgrade4 aut
7001 a Salvador, Maria Joao4 aut
7001 a Riccieri, Valeriau Sapienza University of Rome4 aut
7001 a Mihai, Carinau Carol Davila University of Medicine and Pharmacy4 aut
7001 a Szücs, Gabriella4 aut
7001 a Walker, Ulrich A.u University Hospital Basel4 aut
7001 a Hunzelmann, Nicolasu University Hospital of Cologne4 aut
7001 a Martinovic, Duskau Clinical Hospital Split4 aut
7001 a Smith, Vanessau Ghent University4 aut
7001 a Müller, Carolina De Souzau Federal University of Paraná4 aut
7001 a Montecucco, Carlo Mauriziou Policlinico San Matteo Pavia Fondazione4 aut
7001 a Opris, Danielau Carol Davila University of Medicine and Pharmacy4 aut
7001 a Ingegnoli, Francescau University of Milan4 aut
7001 a Vlachoyiannopoulos, Panayiotis G.u National and Kapodistrian University of Athens4 aut
7001 a Stamenkovic, Bojana4 aut
7001 a Rosato, Edoardou Sapienza University of Rome4 aut
7001 a Heitmann, Stefan4 aut
7001 a Distler, Jörg H Wu University Hospital Erlangen4 aut
7001 a Zenone, Thierryu Centre Hospitalier de Valence4 aut
7001 a Seidel, Matthiasu University Hospital Bonn4 aut
7001 a Vacca, Alessandra4 aut
7001 a De Langhe, Ellenu University Hospitals Leuven4 aut
7001 a Novak, Srdan4 aut
7001 a Cutolo, Mauriziou University of Genoa4 aut
7001 a Mouthon, Lucu Cochin Hospital4 aut
7001 a Henes, Jörgu University Hospital of Tubingen4 aut
7001 a Chizzolini, Carlou Geneva University Hospital4 aut
7001 a von Mühlen, Carlos Alberto4 aut
7102 a Paris Descartes Universityb Sorbonne Paris Nord University4 org
7102 a EUSTAR group
7730 t Annals of the Rheumatic Diseasesd : BMJg 76:11, s. 1897-1905q 76:11<1897-1905x 0003-4967x 1468-2060
8564 u http://dx.doi.org/10.1136/annrheumdis-2017-211448y FULLTEXT
8564 u https://lirias.kuleuven.be/bitstream/123456789/592021/1/annrheumdis-2017-211448.full.pdf
8564 8u https://lup.lub.lu.se/record/1ba55a46-45cb-448d-aa03-d8467a51e521
8564 8u https://doi.org/10.1136/annrheumdis-2017-211448

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