Sökning: onr:"swepub:oai:lup.lub.lu.se:16987df5-29de-4712-a7c3-3b6d9494b540" > Anti-beta 2 glycopr...
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000 | 06682naa a2200841 4500 | |
001 | oai:lup.lub.lu.se:16987df5-29de-4712-a7c3-3b6d9494b540 | |
003 | SwePub | |
008 | 210528s2021 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/16987df5-29de-4712-a7c3-3b6d9494b5402 URI |
024 | 7 | a https://doi.org/10.1177/096120332110142482 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Elkhalifa, Marwau Johns Hopkins University School of Medicine,Alexandria University4 aut |
245 | 1 0 | a Anti-beta 2 glycoprotein I IgA in the SLICC classification criteria dataset |
264 | c 2021-05-06 | |
264 | 1 | b SAGE Publications,c 2021 |
300 | a 6 s. | |
520 | a Objective: Anti-beta 2 glycoprotein I IgA is a common isotype of anti-beta 2 glycoprotein I in SLE. Anti-beta 2 glycoprotein I was not included in the American College of Rheumatology (ACR) SLE classification criteria, but was included in the Systemic Lupus International Collaborating Clinics (SLICC) criteria. We aimed to evaluate the prevalence of anti-beta 2-glycoprotein I IgA in SLE versus other rheumatic diseases. In addition, we examined the association between anti-beta 2 glycoprotein I IgA and disease manifestations in SLE. Methods: The dataset consisted of 1384 patients, 657 with a consensus physician diagnosis of SLE and 727 controls with other rheumatic diseases. Anti-beta 2 glycoprotein I isotypes were measured by ELISA. Patients with a consensus diagnosis of SLE were compared to controls with respect to presence of anti-beta 2 glycoprotein I. Among patients with SLE, we assessed the association between anti-beta 2 glycoprotein I IgA and clinical manifestations. Results: The prevalence of anti-beta 2 glycoprotein I IgA was 14% in SLE patients and 7% in rheumatic disease controls (odds ratio, OR 2.3, 95% CI: 1.6, 3.3). It was more common in SLE patients who were younger patients and of African descent (p = 0.019). Eleven percent of SLE patients had anti-beta 2 glycoprotein I IgA alone (no anti-beta 2 glycoprotein I IgG or IgM). There was a significant association between anti-beta 2 glycoprotein I IgA and anti-dsDNA (p = 0.001) and the other antiphospholipid antibodies (p = 0.0004). There was no significant correlation of anti-beta 2 glycoprotein I IgA with any of the other ACR or SLICC clinical criteria for SLE. Those with anti-beta 2 glycoprotein I IgA tended to have a history of thrombosis (12% vs 6%, p = 0.071), but the difference was not statistically significant. Conclusion: We found the anti-beta 2 glycoprotein I IgA isotype to be more common in patients with SLE and in particular, with African descent. It could occur alone without other isotypes. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
653 | a anti-beta 2 glycoprotein IgA | |
653 | a antiphospholipid antibodies | |
653 | a classification criteria | |
653 | a Systemic lupus erythematosus | |
700 | 1 | a Orbai, Ana Mariau Johns Hopkins University School of Medicine4 aut |
700 | 1 | a Magder, Laurence S.u University of Maryland School of Medicine4 aut |
700 | 1 | a Petri, Michelleu Johns Hopkins University School of Medicine4 aut |
700 | 1 | a Alarcón, Graciela S.u University of Alabama4 aut |
700 | 1 | a Gordon, Carolineu University of Birmingham4 aut |
700 | 1 | a Merrill, Joanu Oklahoma Medical Research Foundation4 aut |
700 | 1 | a Fortin, Paul R.u Laval University4 aut |
700 | 1 | a Bruce, Ian N.4 aut |
700 | 1 | a Isenberg, Davidu University College London4 aut |
700 | 1 | a Wallace, Danielu University of California, Los Angeles4 aut |
700 | 1 | a Nived, Olau Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-oni |
700 | 1 | a Ramsey-Goldman, Rosalindu Northwestern University Feinberg School of Medicine4 aut |
700 | 1 | a Bae, Sang Cheolu Hanyang University4 aut |
700 | 1 | a Hanly, John G.u Dalhousie University4 aut |
700 | 1 | a Sanchez-Guerrero, Jorgeu University of Toronto4 aut |
700 | 1 | a Clarke, Ann E.4 aut |
700 | 1 | a Aranow, Cynthiau Feinstein Institute for Medical Research4 aut |
700 | 1 | a Manzi, Susanu Allegheny Health Network4 aut |
700 | 1 | a Urowitz, Murrayu University of Toronto4 aut |
700 | 1 | a Gladman, Dafna D.u University of Toronto4 aut |
700 | 1 | a Kalunian, Kenu University of California, San Diego4 aut |
700 | 1 | a Werth, Victoria P.u Hospital of the University of Pennsylvania4 aut |
700 | 1 | a Zoma, Asadu Hairmyres Hospital4 aut |
700 | 1 | a Bernatsky, Sashau McGill University Health Center4 aut |
700 | 1 | a Khamashta, Munther4 aut |
700 | 1 | a Jacobsen, SØrenu Copenhagen University Hospital4 aut |
700 | 1 | a Buyon, Jill P.u New York University4 aut |
700 | 1 | a Dooley, Mary Anneu University of North Carolina4 aut |
700 | 1 | a Vollenhoven, Ronald vanu Academic Medical Center of University of Amsterdam (AMC),Vrije Universiteit Amsterdam4 aut |
700 | 1 | a Ginzler, Ellenu SUNY Downstate Health Sciences University4 aut |
700 | 1 | a Stoll, Thomasu Cantonal Hospital of Olten4 aut |
700 | 1 | a Peschken, Christineu University of Manitoba4 aut |
700 | 1 | a Jorizzo, Joseph L.u Weill Cornell Medical College4 aut |
700 | 1 | a Callen, Jeffery P.u University of Louisville Health Sciences Center4 aut |
700 | 1 | a Lim, Samu Emory University4 aut |
700 | 1 | a Inanc, Murat4 aut |
700 | 1 | a Kamen, Diane L.u Medical University of South Carolina4 aut |
700 | 1 | a Rahman, Anisuru University College London4 aut |
700 | 1 | a Steinsson, Kristjanu National University Hospital of Iceland4 aut |
700 | 1 | a Franks, Andrew G.u New York University4 aut |
710 | 2 | a Johns Hopkins University School of Medicineb Alexandria University4 org |
773 | 0 | t Lupusd : SAGE Publicationsg 30:8, s. 1283-1288q 30:8<1283-1288x 0961-2033x 1477-0962 |
856 | 4 | u http://dx.doi.org/10.1177/09612033211014248y FULLTEXT |
856 | 4 | u https://discovery.ucl.ac.uk/10131180/3/Isenberg_Anti-beta%202%20glycoprotein%20I%20IgA%20in%20the%20SLICC%20classification%20criteria%20dataset_AAM.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/16987df5-29de-4712-a7c3-3b6d9494b540 |
856 | 4 8 | u https://doi.org/10.1177/09612033211014248 |
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