WFRF:(Elmer E.)
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Cyclosporine-A enhances choline acetyltransferase immunoreactivity in the septal region of adult rats
- Borlongan, C V (author)
- Stahl, C E (author)
- Keep, M F (author)
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- Watanabe, S (author)
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- (creator_code:org_t)
- 2000
- 2000
- English.
- In: Neuroscience Letters. - 0304-3940. ; 279:2, s. 73-76
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Cyclosporine-A (CsA) is the primary anti-rejection drug used for organ and neural transplantation therapy. In addition to its immunosuppressive action, CsA has been recently shown to exert neuroprotective and neurotrophic effects in the central nervous system when able to cross the blood-brain barrier. Postulated mechanisms for these CsA-induced beneficial effects include the drug's powerful inhibition of the calcium-dependent phosphatase calcineurin (CN) and blockade of the assembly of the mitochondrial permeability transition pore. We report here, for the first time, that adult Wistar rats treated with CsA (10 mg/kg per day, i.p. for 9 days) displayed significantly reduced septal CN expression in combination with enhanced levels of septal choline acetyltransferase (ChAT) immunoreactivity as compared to controls. The observed enhancement of septal ChAT immunoreactivity suggests potential therapeutic utility of CsA for brain disorders characterized by alterations of the cholinergic system.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer’s disease
- Septum
- Cholinergic system
- Immunosuppression
- Neurotrophic effects
- Calcineurin
- Mitochondrial permeability transition pore
Publication and Content Type
- art (subject category)
- ref (subject category)
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- Borlongan, C V
- Stahl, C E
- Keep, M F
- Elmer, Eskil
- Watanabe, S
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
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- and Neurosciences
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- Lund University
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