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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006736naa a2200661 4500
001oai:DiVA.org:liu-174893
003SwePub
008210408s2021 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:146187068
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1748932 URI
0247 a https://doi.org/10.1002/hep4.17002 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1461870682 URI
040 a (SwePub)liud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Aberg, Fredriku Univ Helsinki, Finland; Sahlgrens Univ Hosp, Sweden4 aut
2451 0a A Dynamic Aspartate-to-Alanine Aminotransferase Ratio Provides Valid Predictions of Incident Severe Liver Disease
264 c 2021-03-08
264 1b John Wiley & Sons,c 2021
338 a electronic2 rdacarrier
500 a Funding Agencies|Mary and Georg Ehrnrooth Foundation; Medicinska Understodsforeningen Liv och Halsa; Finska Lakaresallskapet; Finnish Foundation for Cardiovascular Research; National Institute of Diabetes, Digestive and Kidney DiseasesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) [K08DK115883]; Innovation Fund Denmark; European UnionEuropean Commission [668031]; Novo Nordisk FoundationNovo Nordisk Foundation [NNF15OC0016692]; Region of Southern Denmark [K2017--4579]; Center for Innovative Medicine [20180889]
520 a The aspartate-to-alanine aminotransferase ratio (AAR) is associated with liver fibrosis, but its predictive performance is suboptimal. We hypothesized that the association between AAR and liver disease depends on absolute transaminase levels and developed and validated a model to predict liver-related outcomes in the general population. A Cox regression model based on age, AAR, and alanine aminotransferase (ALT) level (dynamic AAR [dAAR]) using restricted cubic splines was developed in Finnish population-based health-examination surveys (FINRISK, 2002-2012; n = 18,067) with linked registry data for incident liver-related hospitalizations, hepatocellular carcinoma, or liver death. The model was externally validated for liver-related outcomes in a Swedish population cohort (Swedish Apolipoprotein Mortality Risk [AMORIS] subcohort; n = 126,941) and for predicting outcomes and/or prevalent fibrosis/cirrhosis in biopsied patients with nonalcoholic fatty liver disease (NAFLD), chronic hepatitis C, or alcohol-related liver disease (ALD). The dynamic AAR model predicted liver-related outcomes both overall (optimism-corrected C-statistic, 0.81) and in subgroup analyses of the FINRISK cohort and identified persons with >10% risk for liver-related outcomes within 10 years. In independent cohorts, the C-statistic for predicting liver-related outcomes up to a 10-year follow-up was 0.72 in the AMORIS cohort, 0.81 in NAFLD, and 0.75 in ALD. Area-under-the-curve (AUC) for detecting prevalent cirrhosis was 0.80-0.83 in NAFLD, 0.80 in hepatitis C, but only 0.71 in ALD. In ALD, model performance improved when using aspartate aminotransferase instead of ALT in the model (C-statistic, 0.84 for outcome; AUC, 0.82 for prevalent cirrhosis). Conclusion: A dAAR score provides prospective predictions for the risk of incident severe liver outcomes in the general population and helps detect advanced liver fibrosis/cirrhosis. The dAAR score could potentially be used for screening the unselected general population and as a trigger for further liver evaluations.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
7001 a Danford, Christopher J.u Beth Israel Deaconess Med Ctr, MA 02215 USA4 aut
7001 a Thiele, Majau Odense Univ Hosp, Denmark; Univ Southern Denmark, Denmark4 aut
7001 a Talback, Matsu Karolinska Institutet4 aut
7001 a Rasmussen, Ditlev Nytoftu Odense Univ Hosp, Denmark4 aut
7001 a Jiang, Z. Gordonu Beth Israel Deaconess Med Ctr, MA 02215 USA4 aut
7001 a Hammar, Niklasu Karolinska Institutet4 aut
7001 a Nasr, Patriku Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken4 aut0 (Swepub:liu)patna19
7001 a Ekstedt, Mattiasu Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken4 aut0 (Swepub:liu)matek92
7001 a But, Annau Univ Helsinki, Finland; Helsinki Univ Hosp, Finland4 aut
7001 a Puukka, Pauliu Karolinska Institutet4 aut
7001 a Krag, Aleksanderu Odense Univ Hosp, Denmark; Univ Southern Denmark, Denmark4 aut
7001 a Sundvall, Joukou Finnish Inst Hlth & Welf, Finland4 aut
7001 a Erlund, Irisu Finnish Inst Hlth & Welf, Finland4 aut
7001 a Salomaa, Veikkou Finnish Inst Hlth & Welf, Finland4 aut
7001 a Stal, Peru Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden4 aut
7001 a Kechagias, Stergiosu Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken4 aut0 (Swepub:liu)steke00
7001 a Hultcrantz, Rolfu Karolinska Institutet4 aut
7001 a Lai, Michelleu Beth Israel Deaconess Med Ctr, MA 02215 USA4 aut
7001 a Afdhal, Nezamu Beth Israel Deaconess Med Ctr, MA 02215 USA4 aut
7001 a Jula, Anttiu Finnish Inst Hlth & Welf, Finland4 aut
7001 a Mannisto, Satuu Finnish Inst Hlth & Welf, Finland4 aut
7001 a Lundqvist, Annamariu Finnish Inst Hlth & Welf, Finland4 aut
7001 a Perola, Markusu Finnish Inst Hlth & Welf, Finland4 aut
7001 a Farkkila, Marttiu Univ Helsinki, Finland4 aut
7001 a Hagstrom, Hannesu Karolinska Institutet4 aut
7102 a Univ Helsinki, Finland; Sahlgrens Univ Hosp, Swedenb Beth Israel Deaconess Med Ctr, MA 02215 USA4 org
7730 t HEPATOLOGY COMMUNICATIONSd : John Wiley & Sonsg 5:6, s. 1021-1035q 5:6<1021-1035x 2471-254X
8564 u https://liu.diva-portal.org/smash/get/diva2:1542578/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep4.1700
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-174893
8564 8u https://doi.org/10.1002/hep4.1700
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:146187068

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