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Sökning: WFRF:(Falus András) > Negative regulatory...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003429naa a2200445 4500
001oai:DiVA.org:uu-421715
003SwePub
008201012s2004 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4217152 URI
0247 a https://doi.org/10.1093/intimm/dxh1792 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Garaczi, Edina4 aut
2451 0a Negative regulatory effect of histamine in DNFB-induced contact hypersensitivity.
264 c 2004-10-11
264 1b Oxford University Press (OUP),c 2004
338 a print2 rdacarrier
520 a Histamine plays an important role in the regulation of various immunological functions. To evaluate the role of histamine in contact hypersensitivity, contact dermatitis was induced with dinitrofluorobenzene (DNFB) in histidine decarboxylase knockout (HDC-/-) histamine-deficient and wild-type mice. The DNFB-induced increase of the ear thickness was significantly higher in HDC-/- mice than in wild-type mice. Using flow cytometry, significantly lower percentages of CD4+ Th and CD8+ Tc cells, and significantly higher percentages of CD45R+ B cells were observed in the regional lymph nodes in HDC-/- mice than in wild-type mice. In the ear specimens of both groups, the majority of the infiltrating cells were neutrophils and macrophages at 24 and 48 h after challenge. Using immunohistochemistry, we observed significantly more CD45+ leukocytes in HDC-/- mice than in wild-type mice. The expression of Th1 (IL-2, IFN-gamma, TNF-alpha) and Th2 (IL-4) mRNAs was examined by quantitative real time RT-PCR in the ear samples. The levels of Th1 cytokine mRNAs both at 24 and 48 h after challenge and IL-4 mRNA at 48 h showed a significantly higher increase in HDC-/- mice than in wild-type mice. These results suggest that histamine plays a negative immunoregulatory role in DNFB-induced contact hypersensitivity.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Dermatologi och venereologi0 (SwePub)302042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dermatology and Venereal Diseases0 (SwePub)302042 hsv//eng
7001 a Széll, Márta4 aut
7001 a Jánossy, Tamás4 aut
7001 a Koreck, Andrea4 aut
7001 a Pivarcsi, Andor4 aut
7001 a Buzás, Edit4 aut
7001 a Pos, Zoltán4 aut
7001 a Falus, András4 aut
7001 a Dobozy, Attila4 aut
7001 a Kemény, Lajos4 aut
7730 t International Immunologyd : Oxford University Press (OUP)g 16:12, s. 1781-8q 16:12<1781-8x 0953-8178x 1460-2377
8564 u http://intimm.oxfordjournals.org/content/16/12/1781.full.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421715
8564 8u https://doi.org/10.1093/intimm/dxh179

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